925 research outputs found
Numerical Simulations of Soil Liquefaction using Stochastic Input Parameters
The influence of spatial variability of soil properties on the results of numerical simulations of dynamically induced pore water pressure is addressed. Random media of NSPT values are generated based on in situ test results. The soil geomechanical properties are evaluated at each location, function of the NSPT values, and finite element simulations of the behavior of a horizontally layered soil subjected to seismic loading are performed. The influence of : (1) assumed distribution of the underlying random variable, (2) scale of fluctuation, and (3) finite element mesh size are discussed in terms of predicted liquefaction index and excess pore pressure build-up
Finite-dimensional representations of twisted hyper loop algebras
We investigate the category of finite-dimensional representations of twisted
hyper loop algebras, i.e., the hyperalgebras associated to twisted loop
algebras over finite-dimensional simple Lie algebras. The main results are the
classification of the irreducible modules, the definition of the universal
highest-weight modules, called the Weyl modules, and, under a certain mild
restriction on the characteristic of the ground field, a proof that the simple
modules and the Weyl modules for the twisted hyper loop algebras are isomorphic
to appropriate simple and Weyl modules for the non-twisted hyper loop algebras,
respectively, via restriction of the action
Role of friction-induced torque in stick-slip motion
We present a minimal quasistatic 1D model describing the kinematics of the
transition from static friction to stick-slip motion of a linear elastic block
on a rigid plane. We show how the kinematics of both the precursors to
frictional sliding and the periodic stick-slip motion are controlled by the
amount of friction-induced torque at the interface. Our model provides a
general framework to understand and relate a series of recent experimental
observations, in particular the nucleation location of micro-slip instabilities
and the build up of an asymmetric field of real contact area.Comment: 6 pages, 5 figure
Experimental evidence of non-Amontons behaviour at a multicontact interface
We report on normal stress field measurements at the multicontact interface
between a rough elastomeric film and a smooth glass sphere under normal load,
using an original MEMS-based stress sensing device. These measurements are
compared to Finite Elements Method calculations with boundary conditions
obeying locally Amontons' rigid-plastic-like friction law with a uniform
friction coefficient. In dry contact conditions, significant deviations are
observed which decrease with increasing load. In lubricated conditions, the
measured profile recovers almost perfectly the predicted profile. These results
are interpreted as a consequence of the finite compliance of the multicontact
interface, a mechanism which is not taken into account in Amontons' law
The dynamics of thin vibrated granular layers
We describe a series of experiments and computer simulations on vibrated
granular media in a geometry chosen to eliminate gravitationally induced
settling. The system consists of a collection of identical spherical particles
on a horizontal plate vibrating vertically, with or without a confining lid.
Previously reported results are reviewed, including the observation of
homogeneous, disordered liquid-like states, an instability to a `collapse' of
motionless spheres on a perfect hexagonal lattice, and a fluctuating,
hexagonally ordered state. In the presence of a confining lid we see a variety
of solid phases at high densities and relatively high vibration amplitudes,
several of which are reported for the first time in this article. The phase
behavior of the system is closely related to that observed in confined
hard-sphere colloidal suspensions in equilibrium, but with modifications due to
the effects of the forcing and dissipation. We also review measurements of
velocity distributions, which range from Maxwellian to strongly non-Maxwellian
depending on the experimental parameter values. We describe measurements of
spatial velocity correlations that show a clear dependence on the mechanism of
energy injection. We also report new measurements of the velocity
autocorrelation function in the granular layer and show that increased
inelasticity leads to enhanced particle self-diffusion.Comment: 11 pages, 7 figure
Observation of the lowest energy gamma-ray in any superdeformed nucleus : 196Bi
New results on the superdeformed Bi nucleus a re reported. We have
observed with the EUROBALL IV -ray spectrometer array a superdeformed
trans ition of 124 keV which is the lowest observed energy -ray in any
superdeformed nucleus. We have de velopped microscopic cranked
Hartree-Fock-Bogoliubov calculations using the SLy4 effective force and a
realistic surface p airing which strongly support the
([651]1/2[752]5/2) assignment of this su
perdeformed band
Costs and Outcomes of Increasing Access to Bariatric Surgery: Cohort Study and Cost-Effectiveness Analysis Using Electronic Health Records
Objectives: To estimate costs and outcomes of increasing access to bariatric surgery in obese adults and in population subgroups of age, sex, deprivation, comorbidity, and obesity category. Methods: A cohort study was conducted using primary care electronic health records, with linked hospital utilization data, for 3,045 participants who underwent bariatric surgery and 247,537 participants who did not undergo bariatric surgery. Epidemiological analyses informed a probabilistic Markov model to compare bariatric surgery, including equal proportions with adjustable gastric banding, gastric bypass, and sleeve gastrectomy, with standard nonsurgical management of obesity. Outcomes were quality-adjusted life-years (QALYs) and net monetary benefits at a threshold of £30,000 per QALY. Results: In a UK population of 250,000 adults, there may be 7,163 people with morbid obesity including 1,406 with diabetes. The immediate cost of 1,000 bariatric surgical procedures is £9.16 million, with incremental discounted lifetime health care costs of £15.26 million (95% confidence interval £15.18–£15.36 million). Patient-years with diabetes mellitus will decrease by 8,320 (range 8,123–8,502). Incremental QALYs will increase by 2,142 (range 2,032–2,256). The estimated cost per QALY gained is £7,129 (range £6,775–£7,506). Net monetary benefits will be £49.02 million (range £45.72–£52.41 million). Estimates are similar for subgroups of age, sex, and deprivation. Bariatric surgery remains cost-effective if the procedure is twice as costly, or if intervention effect declines over time. Conclusions: Diverse obese individuals may benefit from bariatric surgery at acceptable cost. Bariatric surgery is not cost-saving, but increased health care costs are exceeded by health benefits to obese individuals
Arterial Stiffness in a Cohort of Young People Living With Perinatal HIV and HIV Negative Young People in England
Background: Antiretroviral therapy (ART) has increased life expectancy and consequently the risk of cardiovascular disease (CVD) in adults living with HIV. We investigated the levels and predictors of arterial stiffness in young people (YP) living with perinatal HIV (PHIV) and HIV negative YP in the Adolescents and Adults Living with Perinatal HIV (AALPHI) study. Methods: AALPHI was a prospective study evaluating the impact of HIV infection and exposure to ART on YP living with PHIV (aged 13-21 years) who had known their HIV status for at least 6 months, and HIV negative YP (aged 13-23 years) who either had a sibling, friend or parent living with HIV. Participants were enrolled from HIV clinics and community services in England. Two hundred and thirteen PHIV and 65 HIV negative YP (42% siblings of PHIV) had pulse wave velocity (PWV) measurements taken (Vicorder software) from the supra-sternal notch to the middle of the thigh cuff, at their second interview in the study between 2015 and 2017. Average PWV was calculated from the three closest readings (≥3 and ≤ 12 m/s) within 0.6 m/s of each other. Linear regression examined predictors of higher (worse) PWV, including age, sex, HIV status and height as a priori, ethnicity, born outside UK/Ireland, alcohol/nicotine/drug use, weight, waist-to-hip-ratio, mean arterial pressure (MAP), caffeine 2 h before PWV and nicotine on day of PWV. A separate PHIV model included CD4, viral load, years taking ART and ART regimen. Findings: One hundred and twenty eight (60%) PHIV and 45 (69%) HIV negative YP were female (p = 0.18), with median (IQR) age 18 (16, 20) and 18 (16, 21) years (p = 0.48) respectively. Most PHIV were taking a combination of three ART drugs from two classes. There was a trend toward higher (worse) mean PWV in the PHIV group than the HIV negative group [unvariable analysis 6.15 (SD 0.83) m/s vs. 5.93 (0.70) m/s, respectively, unadjusted p = 0.058], which was statistically significant in the multivariable analysis [adjusted p (ap) = 0.020]. In multivariable analysis being male (ap = 0.002), older age (ap < 0.001), higher MAP (ap < 0.001) and nicotine use on day of measurement (ap = 0.001) were also predictors of higher PWV. The predictors were the same in the PHIV model. Interpretation: By late adolescence PHIV had worse PWV in comparison to HIV negative peers, and traditional risk factors for CVD (higher arterial pressure, being male and older age) were associated with higher PWV values. Regular detailed monitoring of cardiovascular risk factors should become standard of care for every young person with PHIV worldwide
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