7 research outputs found

    Lieb-Robinson bounds for commutator-bounded operators

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    We generalize the Lieb-Robinson theorem to systems whose Hamiltonian is the sum of local operators whose commutators are bounded

    Loop quantum gravity: the first twenty five years

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    This is a review paper invited by the journal "Classical ad Quantum Gravity" for a "Cluster Issue" on approaches to quantum gravity. I give a synthetic presentation of loop gravity. I spell-out the aims of the theory and compare the results obtained with the initial hopes that motivated the early interest in this research direction. I give my own perspective on the status of the program and attempt of a critical evaluation of its successes and limits.Comment: 24 pages, 3 figure

    Generalized Uncertainty Principle and Self-dual Black Holes

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    The Generalized Uncertainty Principle suggests corrections to the Uncertainty Principle as the energy increases towards the Planck value. It provides a natural transition between the expressions for the Compton wavelength below the Planck mass and the black hole event horizon size above this mass. It also suggests corrections to the the event horizon size as the black hole mass falls towards the Planck value, leading to the concept of a Generalized Event Horizon. Extrapolating below the Planck mass suggests the existence of a new class of black holes, whose size is of order the Compton wavelength for their mass. Such sub-Planckian black holes have recently been discovered in the context of loop quantum gravity and it is possible that this applies more generally. This suggests an intriguing connection between black holes, the Uncertainty Principle and quantum gravity

    Rivaroxaban with or without aspirin in stable cardiovascular disease

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    BACKGROUND: We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS: In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. RESULTS: The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=−4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P<0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P=0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban-alone group. CONCLUSIONS: Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events
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