Microplastics in the gut of anchovies caught from the mud bank area of Alappuzha, Kerala

Marine litter or the non-degradable wastes generated due to anthropogenic activities, has been recognized as one of the major threats to coastal marine ecosystem in the 21st century. These originate mainly from land and enter the aquatic ecosystem through land runoff and also when they are discarded by human beings directly into the coastal waters

National Marine Debris Management Strategy to conserve marine ecosystems

Marine debris which is defined as any persistent,manufactured or processed solid material discarded,disposed of or abandoned in the marine and coastalenvironment is one of the most pervasive, yetpotentially solvable, pollution affecting the world’soceans, coastal ecosystems and rivers. Whereasimpacts of most anthropogenic activities are usuallyfound near the point source, marine debris has beenfound to impact even distant locations, oftenaffecting uninhabited areas also. According toUnited Nations Joint Group of Experts on theScientific Aspects of Marine EnvironmentalProtection (GESAMP), 60 to 80%, of the global litterfound in the coastal and marine ecosystems hasoriginated from land and only the rest from seabased activities. The slow degradable nature ofmarine litter and the potential to pollute all spheresof oceans irrespective of point source has raisedthe alarm bells

National Marine Debris Management Strategy to conserve marine ecosystems

Marine debris which is defined as any persistent,manufactured or processed solid material discarded,disposed of or abandoned in the marine and coastalenvironment is one of the most pervasive, yetpotentially solvable, pollution affecting the world’soceans, coastal ecosystems and rivers. Whereasimpacts of most anthropogenic activities are usuallyfound near the point source, marine debris has beenfound to impact even distant locations, oftenaffecting uninhabited areas also. According toUnited Nations Joint Group of Experts on theScientific Aspects of Marine EnvironmentalProtection (GESAMP), 60 to 80%, of the global litterfound in the coastal and marine ecosystems hasoriginated from land and only the rest from seabased activities. The slow degradable nature ofmarine litter and the potential to pollute all spheresof oceans irrespective of point source has raisedthe alarm bells

Research priorities in Maternal, Newborn, & Child Health & Nutrition for India:An Indian Council of Medical Research-INCLEN Initiative

In India, research prioritization in Maternal, Newborn, and Child Health and Nutrition (MNCHN) themes has traditionally involved only a handful of experts mostly from major cities. The Indian Council of Medical Research (ICMR)-INCLEN collaboration undertook a nationwide exercise engaging faculty from 256 institutions to identify top research priorities in the MNCHN themes for 2016-2025. The Child Health and Nutrition Research Initiative method of priority setting was adapted. The context of the exercise was defined by a National Steering Group (NSG) and guided by four Thematic Research Subcommittees. Research ideas were pooled from 498 experts located in different parts of India, iteratively consolidated into research options, scored by 893 experts against five pre-defined criteria (answerability, relevance, equity, investment and innovation) and weighed by a larger reference group. Ranked lists of priorities were generated for each of the four themes at national and three subnational (regional) levels [Empowered Action Group & North-Eastern States, Southern and Western States, & Northern States (including West Bengal)]. Research priorities differed between regions and from overall national priorities. Delivery domain of research which included implementation research constituted about 70 per cent of the top ten research options under all four themes. The results were endorsed in the NSG meeting. There was unanimity that the research priorities should be considered by different governmental and non-governmental agencies for investment with prioritization on implementation research and issues cutting across themes

Predicting Clinical Trial Outcomes Using Drug Bioactivities through Graph Database Integration and Machine Learning

Murali V, Pradyumna YM, Königs C, et al. Predicting Clinical Trial Outcomes Using Drug Bioactivities through Graph Database Integration and Machine Learning. Chemical Biology & Drug Design. 2022.The ability to estimate the probability of a drug to receive approval in clinical trials provides natural advantages to optimizing pharmaceutical research workflows. Success rates of clinical trials have deep implications for costs, duration of development, and under pressure due to stringent regulatory approval processes. We propose a machine learning approach that can predict the outcome of the trial with reliable accuracies, using biological activities, physicochemical properties of the compounds, target-related features, and NLP-based compound representation. In the above list, biological activities have never been used as an independent variable towards the prediction of clinical trial outcomes. We have extracted the drug-disease pair from clinical trials and mapped target(s) to that pair using multiple data sources. Empirical results demonstrate that ensemble learning outperforms independently trained, small-data ML models. We report results and inferences derived from a Random forest classifier with an average accuracy of 93%, and an F1 score of 0.96 for the 'Pass' class. 'Pass' refers to one of the two classes (Pass/ Fail) of all clinical trials and the model performed well in predicting the "Pass" category. Through the analysis of feature contributions to predictive capability, we have demonstrated that bioactivity plays a statistically significant role in predicting clinical trial outcome. A significant effort has gone into the production of the dataset that, for the first time, integrates clinical trial information with protein targets. Cleaned, organized, integrated data and code to map these entities, - created as a part of this work, are available open-source. This reproducibility and the freely available code ensure that researchers with access to deep curated and proprietary clinical trial databases (we only use open-source data in this study) can further expand the scope of the results. This article is protected by copyright. All rights reserved

Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen

The induction of regulatory T cells (Tregs) to suppress aberrant inflammation and immunity has potential as a therapeutic strategy for asthma. Recently, we identified key immunoregulatory components of Streptococcus pneumoniae, type 3 polysaccharide and pneumolysoid (T+P), which suppress allergic airways disease (AAD) in mouse models of asthma. To elucidate the mechanisms of suppression, we have now performed a thorough examination of the role of Tregs. BALB/c mice were sensitized to OVA (day 0) i.p. and challenged intranasal (12–15 d later) to induce AAD. T+P was administered intratracheally at the time of sensitization in three doses (0, 12, and 24 h). T+P treatment induced an early (36 h–4 d) expansion of Tregs in the mediastinal lymph nodes, and later (12–16 d) increases in these cells in the lungs, compared with untreated allergic controls. Anti-CD25 treatment showed that Treg-priming events involving CD25, CCR7, IL-2, and TGF-β were required for the suppression of AAD. During AAD, T+P-induced Tregs in the lungs displayed a highly suppressive phenotype and had an increased functional capacity. T+P also blocked the induction of IL-6 to prevent the Th17 response, attenuated the expression of the costimulatory molecule CD86 on myeloid dendritic cells (DCs), and reduced the number of DCs carrying OVA in the lung and mediastinal lymph nodes. Therefore, bacterial components (T+P) drive the differentiation of highly suppressive Tregs, which suppress the Th2 response, prevent the Th17 response and disable the DC response resulting in the effective suppression of AAD

Doorstroomexperiment Zuiderpark/Zwaanspreng in Apeldoorn

OTB Research Institute for the Built Environmen

Programming of the lung in early life by bacterial infections predisposes to chronic respiratory disease

There is emerging evidence that chronic respiratory diseases such as asthma and emphysema may originate in early life. Respiratory infections with certain bacterial pathogens such as <i>Chlamydia, Haemophilus influenzae</i> and <i>Streptococcus pneumoniae</i> in early life may promote permanent deleterious changes in immunity, lung structure, and function that predispose to, or increase the severity of chronic respiratory diseases in later life. For example, these infections increase immune responses, which drive subsequent asthma pathogenesis. Targeting the pathways involved with specific inhibitors or agonists may prevent these consequences of early-life infection. Vaccination and immunomodulatory therapies that control the infections and their sequelae may also be efficacious

Not Available

Not AvailableMarine litter or the non-degradable wastes generated due to anthropogenic activities, has been recognized as one of the major threats to coastal marine ecosystem in the 21st century. These originate mainly from land and enter the aquatic ecosystem through land runoff and also when they are discarded by human beings directly into the coastal waters.Not Availabl