The microRNAs of Epstein–Barr Virus are expressed at dramatically differing levels among cell lines

AbstractEpstein–Barr Virus (EBV) encodes multiple microRNAs (miRNAs) from two primary transcripts, BHRF1 and the BARTs. The expression of BHRF1 miRNAs is dependent on the type of viral latency, whereas the BART miRNAs are expressed in cells during all forms of latency. It is not known how these miRNAs are otherwise regulated, though. We have used quantitative, stem-loop, real-time PCR to measure the expression of EBV's miRNAs and found them to differ nearly 50- and 25-fold among all tested cell lines and among EBV-positive Burkitt's lymphomas, respectively. In addition, the expression of individual BART miRNAs within a cell can differ by 50-fold or more despite the fact these miRNAs are likely transcribed together as a single primary transcript. These measurements are illuminating: they indicate that few of EBV's miRNAs are expressed at levels comparable to those of cellular miRNAs in most cell lines and therefore likely function interdependently

Design and construction of a prototype ACTS propagation terminal

The launch schedule for the Advanced Communication Technology Satellite (ACTS) spacecraft did not leave sufficient time for completion of the prototype ACTS Propagation Terminals (APT) prior to initiation of the APT production phase. In fact, the approach used was to construct and test all subassemblies of the terminal with special emphasis on the technically challenging portions. These include the RF front end that uses a state-of-the-art down converter which integrates a low noise amplifier, mixer, post amplifier, filter, and local oscillator port frequency doubler into a single small package. In addition, a new digital receiver that uses the latest DSP technology was developed. Both of these subassemblies were thoroughly tested. The highest risk technology in the APT program was the digital receiver. Several candidate algorithms and DSP chips were investigated early on, primarily under JPL sponsorship. A receiver was constructed based on Texas Instruments chip. The final prototype digital receiver was one based on an Analog Devices chip. The design and test results are documented in a report prepared for this grant. A Primary Design Review (PDR) was conducted 30 May 1991, and a Critical Design Review was held 7 Jul. 1992. Final complete documentation of the APT's will appear in the form of three reports: a hardware description report, a report on the data collection code (ACTS VIEW), and a report on the preprocessing code

The Lantern Vol. 29, No. 1, December 1961

• King Fitzgerald\u27s Court • Deliberate Beyond Conception • Jean • The Dumb Superman • Epilogue to Death • Afternoon in August • Eichmann • A Nose Thumbed • Observation • The Forgetful Evening • Truditur Dies Die • The Deserted Pier • Thoughts on Love • Laughter • A Waste? • Villanelle: Interlude • Lines on a Rhetorical Question • Villanellehttps://digitalcommons.ursinus.edu/lantern/1081/thumbnail.jp

The Ursinus Weekly, November 21, 1960

Miss Liberty Bowl title won by UC\u27s Sandra Motta • U. of P. chaplain speaks to Canterbury Club • Quiet hours enforced by W.S.G.A. senate • New Outing Club formed; Woodruff acting chairman • ICG makes plans to attend state convention in April • Dr. Baker and Dr. Zucker discuss disarmament at IRC meeting • Philadelphia orchestra presents second student concert, Dec. 6 • Phoenixville site of Phila. Civic Concert • Seminar accepts applications now • Young Republicans selected by NYR • Annual Messiah to be presented on Dec. 8th • Dark Victory to be presented by Curtain Club on December 9, 10 • Lutheran Club invites students to its first meeting tonight • Eight junior men nominated for Ruby business manager • Spanish Club sponsors Latin American parley • Lecture on French art heard by French Club • Editorial: Togetherness • Land of the midnight sun • For student teachers only • Other side of the desk • Outside reading • An incohesive account of things I saw in one weekend in New York • Head coach Fry is interviewed • Football statistics • St. Joe\u27s takes MASCAC honors • Curtis II intramural football champions • Soccer records winless season • Book review: Advise & consent • Sketches of Spain • Junior class Bowery held on November 19 • Ursinus Circle hears Dr. G.S. Pancoast speak • Ursinus coed exchange student now in Spain • Omega Chi sisters welcome ten pledges at pizza party • Poetry, short stories concern English Club at Dec. 9 meeting • Women\u27s Athletic Association sponsors bowling outinghttps://digitalcommons.ursinus.edu/weekly/1327/thumbnail.jp

The Ursinus Weekly, December 11, 1961

Harrisburg calls two U.C. seniors for budget talks • Ursinus College\u27s fourteen Who\u27s Who students drawn from entire spectrum of campus activity • Caroling, banquets brighten last college week of 1961 • Weekly circulation up 41% over previous year • Special education speech delivered Tuesday to PSEA • Joint meeting held by science clubs • Senior Bob Allen elected constable in Scranton ward; Ousts incumbent • Christmas communication • Debaters show promise; Sall excels in tourney • College hockey players cited for outstanding skill • Fraternities, sororities spread cheer with orphans\u27 Christmas parties • Editorial: The holiday here • Ursinus in the past • Letters to the editor • Study in noisemaking • Dismal week for Bear cagers • Mark Borak\u27s cage play encouraging; Sophomore uses jump shot effectively • Leber-South volleyball streak at eleven gameshttps://digitalcommons.ursinus.edu/weekly/1307/thumbnail.jp

The Ursinus Weekly, January 7, 1963

Burst water pipes in 724 lead to semi-evacuation • Speaker from GE will discuss US in space race • PSEA features talks by grad, student teachers • Ed Myers selected representative to National Committee for Youth • College laments death of director Douthett • Psychiatry topic of pre-med meeting • Dolman attends forum on education problems • New heating & power plant now in service • Cub & Key, men\u27s honorary, now accepting applications • Curtain Club version of Antigone scheduled for second semester • Dr. Vorrath concludes discussion of changes in Spanish courses • Schweiker talks on GOP future • Leber open house a Christmas highlight • Chessmen compete in national event • Lynne Maloney, Miss Penna. \u2761, wed last month • Editorial: Unjust, unfair, unwise • Letters to the editor • Snyder to train Civil Defense people • Wrestlers open season Saturday by smashing scared Fords 31-3 • Ursinus gridmen named to MAC all-star teams • Netmen downed by Haverford 72-56 • Intramural story • Ursinus women\u27s club honors Marion Spanglerhttps://digitalcommons.ursinus.edu/weekly/1284/thumbnail.jp

The Ursinus Weekly, February 27, 1961

Student-faculty show to climax charity drive • ICG holds banquet at Immaculata • Dr. Elmer H. Funk addresses students • Power lines snap, disrupt campus • YM-YWCA plans fireside chats, first will be held on March 1 • Jun Kawashima addresses PSEA on Japan\u27s education • WSGA plans two demonstrations • Meistersingers open season at Faith Church • Frosh girls, reps receive colors on February 23 • U.C. students dine with Republicans • AF recruiter offers ACPP applications • International Relations Club to hear speaker on Finland • Joan Meszaros elected Spring Festival queen • Jazz festival in Fla. over recess • Placement Office posts job listing • Newman Club to hold next meeting on March 6 • Editorial: Apathy again • Eichmann: Perhaps a case of injustice • Northbound • From the continent to the cottage • Book review: The same door • Chestnut Hill falls to badminton team • Girls\u27 swimming team defeats Beaver 44-21 • Thinclads have practice meet with Delaware • Intramural corner • Lassies cop two during past week; Crosley stars • Basketball team split; End with 6-11 season • Grapplers win 2, down Drexel, PMC • Greek gleanings • Letters to the editor • Like I went to a work camphttps://digitalcommons.ursinus.edu/weekly/1334/thumbnail.jp

The Ursinus Weekly, March 20, 1961

Peiffer is prom queen; Cub & Key taps 5 men • Men urged to take April SSCQ tests • A pair of lunatics, Curtain Club offering • YWCA worker to speak Monday in Paisley Hall • French Club attends Comedie Francaise • Brownback-Anders hears Ben Hauser, Jeff med student • Bogel wins two posts at meeting • Carolyn Boyer elected into Stars and Players • Ed Myers wins SPSEA regional presidential post • Festival concessions encouraged by WSGA • Students sought for jobs in amusement parks • John Swinton is named as new Weekly editor • Holl to address Young Republicans • Campus Chest figures released • Four seniors placed as high school teachers • Officer nominations invited by YM-YWCA • Father Conran to address Newman Club tonight at 6:30 • Editorial: Thank you • Letters to the editor • Eccentric circles • What does organized labor want? • Chapel commentary • Archaeology and the Bible • Intramural corner • Cindermen boast greater depth • Mermaids lose to Swarthmore, 45-30 • Girl basketballers chalk up 2 more • Norm Bramall to present tennis clinic on Thurs. • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1337/thumbnail.jp

The Ursinus Weekly, November 19, 1962

Surprise, it\u27s \u2763 named theme for Senior Ball on November 30 • Ground will be broken second semester for UC\u27s new million dollar dining hall • Peace Corps agent to visit campus • Fall play termed entertaining • Konick discusses teaching devices • Ursinus alumni hit $240,000 mark in fund drive • Dean Rothenberger attends conference • New Life\u27s Haymen speaks in chapel • Whitians hold tea for upperclass women • Lesley Frost discusses poetry in Forum talk • Moretz and Gladstone elected co-editors of the 1964 Ruby • Stephen Blickman joins recent Koffee Klatch • Virus infection hits many UC students • Student concert held last week • Hungarian prof visits campus • Editorial: Good luck, Mort! • Critical review of John Hersey\u27s wartime novel A bell for Adano • Letters to the editor • Dr. Armstrong tells Weekly of plans for third European travel seminar • Clock over UC\u27s library entrance termed unique piece of machinery • Soccermen drop season finales to Drexel, F&M • Goalie Cliff Kuhn plays fearlessly • Football season in retrospect • Wrestling begins with new coach • Ping-pong tournament progresses under WAA • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1281/thumbnail.jp

The Ursinus Weekly, June 5, 1961

198 diplomas sum up 4 Ursinus years: Prizes bestowed on outstanding Ursinus students • Sandberg \u2761 valedictorian; Graduates summa cum laude • Four honorary degrees awarded this morning: Robert N. Hilkert delivers address to Ursinus\u27 198 senior graduates • Roadside billboard inspiration for Hilkert\u27s speech • Cash prize given four cited for teaching merit • Barbara Pine wins scholarship; Her blindness no obstacle • Biology instructor leaves to tie up loose ends • Amigo to retire; Students\u27 friend for eleven years • Dr. Paisley\u27s death saddens commencement; Board President served Ursinus for 51 years • Newspaperman elected new trustee board head • September may bring 280 freshmen; U.C. Admissions Department reports • New Weekly ad manager wins Wayne Brown prize • Editorial: Sharpened incisors; Good luck • Ursinus in the past • Art of understanding • Seniors submit post-graduation plans; Many teach, work for further degrees • Lacrosse players undefeated again; Trample Drexel • Snell softballers post 3-2 log; Ask more games • Intramural corner • Wait\u27ll next year when nine starters return to diamond • Lynne Crosley lacrosse all-American first team • Netmen competent despite 3-5 log; Famous is MVP • Sport page outlet for creativity, magazine writes • Track team tallies 5-5 \u2761 record; Wise made captain • Morgan finally defeated; Moran wins in AAU run • Mrs. Shryock to retire; Mrs. Bugelholl plans move • Ursinus professor to attend nuclear session • Organizations list late election results • Ursinus College gets $92,000 in Lehigh estate • Late track news: Morgan runs 4:04.2 in Boardwalk Mile • Dr. Creager reported doing well; Needs rest • Ursinus awarded$12,000 F. J. Clamer memorial fundhttps://digitalcommons.ursinus.edu/weekly/1344/thumbnail.jp