Two-dimensional model of nanoparticle deposition in the alveolar ducts of the human lung

In this paper a mathematical model for nanoparticle deposition in the alveolar ducts of the human lung airways is proposed. There were huge inconsistencies in deposition between ducts of a particular generation and inside every alveolated duct, signifying that limited particle concentrations can be much bigger than the mean acinar concentration. A large number of particles are unsuccessful to way out the structure during expiration. Finite difference method has been used to solve the unsteady nonlinear Navier–Stokes equations in cylindrical coordinate system governing flow assuming axial symmetry under laminar flow condition so that the problem efficiently turns into two-dimensional. An extensive quantitative study is performed through numerical computations of the preferred quantities having physiological importance through their graphical demonstration so as to authenticate the applicability of the current model

Survey on Hardware Implementation of Montgomery Modular

This paper gives the information regarding different methodology for modular multiplication with the modification of Montgomery algorithm. Montgomery multiplier proved to be more efficient multiplier which replaces division by the modulus with series of shifting by a number and an adder block. For larger number of bits, Modular multiplication takes more time to compute and also takes more area of the chip. Different methods ensure more speed and less chip size of the system. The speed of the multiplier is decided by the multiplier. Here three modified Montgomery algorithm discussed with their output compared with each other. The three methods are Iterative architecture, Montgomery multiplier for faster Cryptography and Vedic multipliers used in Montgomery algorithm for multiplication.Here three boards have been used for the analysis and they are Altera DE2-70, FPGA board Virtex 6 and Kintex 7

Survey on Hardware Implementation of Montgomery Modular

This paper gives the information regarding different methodology for modular multiplication with the modification of Montgomery algorithm. Montgomery multiplier proved to be more efficient multiplier which replaces division by the modulus with series of shifting by a number and an adder block. For larger number of bits, Modular multiplication takes more time to compute and also takes more area of the chip. Different methods ensure more speed and less chip size of the system. The speed of the multiplier is decided by the multiplier. Here three modified Montgomery algorithm discussed with their output compared with each other. The three methods are Iterative architecture, Montgomery multiplier for faster Cryptography and Vedic multipliers used in Montgomery algorithm for multiplication.Here three boards have been used for the analysis and they are Altera DE2-70, FPGA board Virtex 6 and Kintex 7

ANTI-ATHEROSCLEROTIC AND LIPID LOWERING EFFECTS OF CINNAMOMUM VERUM IN CHOLESTEROL-FED RABBITS

Objective: The present study was designed to investigate the antihyperlipidemic and anti-atherosclerotic activity of 70% methanolic crude extract of Cinnamomum verum bark in high cholesterol-fed diet rabbits.Methods: C. verum extract was administered at a dose level of 200 mg/kg and 300 mg/kg (p. o) daily for 120 d to cholesterol-fed rabbits. Lipid profile in serum and histological changes in heart and aorta were investigated. The statistical analysis was carried out by student's ‘t'test.Results: Plant extract showed a significant decrease in the levels of serum total cholesterol, triglycerides, phospholipids, LDL, VLDL (P ≤ 0.001) in a dose-dependent manner in treated animals. HDL ratio improved overwhelmingly as well as the marked decline was also noticed in the atherogenic index after administration with C. verum extract. Histopathological examinations demonstrated less cholesterol deposits in the aorta and significant increase in lumen size of coronary arteries of high cholesterol diet animals given C. verum compared to the high cholesterol diet animals not given C. verum supplement.Conclusion: The phytochemical analysis of methanol extracts indicated a strong presence of alkaloids, flavonoids, tannins, phenols, saponins and fatty acids may be responsible for the significant hypolipidaemic as well as antiatherosclerotic activity. Our study exhibited that the methanol extract of C. verum bark is a potent hypolipidaemic agent and decreased cholesterol deposition in the aorta and plaque formation process in the coronary artery of high cholesterol diet animals

Two-dimensionally periodic phases in mixtures of compounds made of rodlike and bent-core molecules

We report two distinct types of two-dimensionally periodic phases in different concentration regions of a binary system composed of the bent-core (BC) compound 1,3-phenylene bis[4-(3-methylbenzoyloxy)]4'-n-dodecylbiphenyl 4'-carboxylate (BC12) and the rodlike (R) compound 4-n-octyloxy 4'-cyanobiphenyl (8OCB). BC12 exhibits only the lamellar B2 phase. 8OCB which has a highly polar cyano end group exhibits the smectic-Ad phase with a lamellar structure of partial bilayers made of antiparallel pairs of the polar molecules. The molecular arrangements in the two-dimensionally periodic phases have been deduced based on optical microscopy, polarized infrared and x-ray diffraction studies. The arrangement in the two-dimensionally periodic phase in lower concentration ranges of BC12 (24 to 35 mol%) is dictated by the partial bilayer structure formed by the rods. The BC molecules arrange themselves with their arrow axes parallel to the long axes of the R molecules and the structure conforms to the c2mm space group symmetry. In higher concentration ranges of BC12 (35 to 60 mol%) the structure is dominated by the BC molecules, to form the familiar B1 phase with the p2mg space group symmetry. The R molecules lie at the interfaces of these domains stabilizing the structure

A Study of Innovative Attitude of Indian Entrepreneurs of Various Industries in the Context to Educational and Economic Background

The latest lifestyle or recent trends are the result of innovative efforts undertaken by entrepreneurs. It is the thirst of entrepreneurs that gives birth to a new product. To survive in economy innovations are essentials. Many entrepreneurs do not innovate but imitate and even though they earn handsome. Innovative attitudes may not be the property carrying by every entrepreneur. Not only but it might be the result of a multifold factors. So a research is conducted in Saurashtra region of Gujarat state. A sample of 209 entrepreneurs of various 7 prominent industries of Saurashtra have been selected and compared on the grounds of innovation. The study compares innovative attitude of entrepreneurs based on their educational qualifications and economic background. The results revealed that no significant difference is noticed among the various entrepreneurs of various industries based on innovation. They differed significantly while compared on the grounds of educational qualifications and economic backgrounds

ANTI-ATHEROSCLEROTIC ACTIVITY OF ELAEOCARPUS GANITRUS ROXB. IN CHOLESTEROL-FED RABBITS

  Objectives: Atherosclerosis was experimentally induced in New Zealand white male rabbits by cholesterol feeding for 120 days for investigating effects of 70% ethanolic Elaeocarpus ganitrus seed extract (EEGS) against atherosclerosis.Methods: Anti-atherosclerotic activity of E. ganitrus extract was evaluated at a dose level of 250 and 500 mg/kg of body weight (p.o). On 121st day, the animals were sacrificed to collect the aorta for determining tissue lipid profile, antioxidant parameters, and histopathological changes. One-way ANOVA followed by Tukey's multiple comparison test was used for the statistical analysis.Results: Aorta of cholesterol-fed rabbits for 120 days showed marked elevation in total cholesterol, triglycerides, and phospholipids. EEGS extract treatment significantly (p≤0.01, ≤0.001) corrected disturbed lipid profile in cholesterol-fed rabbits in a dose-dependent manner during the 60 days of the treatment period. A significant reduction in lipid peroxidation and a considerable raise in glutathione, catalase, and superoxide dismutase levels (p≤0.01, ≤0.001) were accompanied by post-treatment with EEGS extract to cholesterol-fed rabbits. The histopathological modifications such as accumulation of foam cells, atheromatous plaque formation, and lumen size reduction supported the successful induction of atherosclerosis in rabbits. The treated rabbits showed significant protective effect by lowering the deposition of cholesterol and increasing the lumen size compared to cholesterol-fed group.Conclusions: Phytoconstituents such as alkaloids, tannins, flavonoids, steroids, triterpenoids, and carbohydrates in the ethanolic extract may be attributed to effective anti-atherosclerotic and antioxidant activity of plant extract. Our study exhibited that EEGS extract could be a potent herbal therapeutic agent for the treatment of atherosclerosis and hypercholesterolemia-related diseases

On some liquid crystalline phases exhibited by compounds made of bent-core molecules and their mixtures with rod-like molecules

In most homologous series of compounds made of bent-core (BC) molecules, the B2, B1 and B6 phases occur as the chain length decreases. We have studied binary mixtures of the compound 1,3-phenylene bis[4-(3-methylbenzoyloxy)]4-n-dodecylbiphenyl 4'-carboxylate (BC12) which exhibits the B2 phase with the compound 4-biphenylyl 4'-n-undecyloxybenzoate (BO11) made of rod-like (R) molecules. We find the above sequence of occurrence of the B phases with increasing concentration of BOH. In this paper we describe the physical origin for the formation of these phases in both pure compounds and in the mixtures. We have also found the occurrence of the biaxial smectic A phase when the BO11 concentration is increased to 87-95.5 mol%. We also report on another binary system composed of BC12 and 4-n-octyloxy 4'- cyanobiphenyl (8OCB) made of R molecules. This system exhibits the biaxial smectic A phase down to 30°C. Using polarized infrared spectroscopy we find that the mutual orientation of the R and BC molecules in the SmAdb liquid crystal is such that the arrow axes of the BC molecules are along the layer normal of the partial bilayer smectic structure formed by the rods. We also describe unusual growth patterns obtained when the nematic phase transforms to the SmAdb phase in a mixture with 24 mol% of BC12

A Study of Innovative Attitude of Indian Entrepreneurs of Various Industries in the Context to Educational and Economic Background

The latest lifestyle or recent trends are the result of innovative efforts undertaken by entrepreneurs. It is the thirst of entrepreneurs that gives birth to a new product. To survive in economy innovations are essentials. Many entrepreneurs do not innovate but imitate and even though they earn handsome. Innovative attitudes may not be the property carrying by every entrepreneur. Not only but it might be the result of a multifold factors. So a research is conducted in Saurashtra region of Gujarat state. A sample of 209 entrepreneurs of various 7 prominent industries of Saurashtra have been selected and compared on the grounds of innovation. The study compares innovative attitude of entrepreneurs based on their educational qualifications and economic background. The results revealed that no significant difference is noticed among the various entrepreneurs of various industries based on innovation. They differed significantly while compared on the grounds of educational qualifications and economic backgrounds

Effect of metformin on fibrinolysis in type 2 diabetes mellitus: an explorative study

Type 2 diabetes mellitus (T2DM) is associated with a high incidence of vascular disease which can cause significant morbidity and mortality. The risk of cardiovascular mortality in T2DM patients is observed to be more compared to the age-matched subjects. This is attributed to depression of the fibrinolytic system which maintains patency of blood vessels. Endogenous inhibitors such as plasminogen activator inhibitor-1 (PAI-1) inhibit the activation of plasminogen and thus prevent the degradation of fibrinogen. In T2DM there is increased levels of PAI-1. Such a state of altered fibrinolysis is attributed to insulin resistance. A previous study done at our institute demonstrated higher euglobulin lysis time (ELT) in T2DM patients than controls, suggesting altered fibrinolytic activity in the former group. D-dimer is a degradation product of fibrin. Its presence indicates a state of hypercoagulability.  In a study by Nwose et al rise in D-dimer levels were observed in diabetics, especially with cardiovascular complications as compared to controls indicating D-dimer could be a useful marker for predicting the complications in T2DM