Smart Pawon: Smart Panti Asuhan Web on Network Sebagai Teknologi Tepat Guna Untuk Pengembangan Panti Asuhan Di Kota Malang

Orphanages as institutions which accommodate, nurture, and educate orphans and underprivileged, majority are unable to survive long due to lack of public support. The lack of such assistance due to lack of publication of the existence of an orphanage to the general public and donors. To solve this problem, we did community service to orphanages in order to publicize its existence to the general public and donors with the title: Smart Pawon: “Smart Orphanage Web On Network as the Applied Technology for Developing Orphanage in Malang". The objective of this community service is to publicize the existence of the orphanage to the public and donors that will be easier for them to locate and provide assistance to orphanages. With the help of the community and donors, the orphanage is expected to be able to survive and rapidly evolving. This community service has been carried out for 4 months from preparation, data collection, purchase a domain and website creation, website management training and publications website\u27s existence. Equipment used include computers, the Internet, and the supporting equipment such as tables, and electrical current. Community service that has been done has realized the target outcome is the creation of a website holding orphanages www.pawon.net site map with the address, and the creation of a website that is a partner orphanage orphanage website Nurul Abyadh www.nurulabyadh.com, Sunan Ampel orphanage website www.pa-sunanampel.com, website – Taqwa-Alqolbi orphanage www.taqwa-alqolbi.com. As a result, the community service has been declared a success because there has been a significant increase in the number of donations to the orphanage partners

Pengaruh Susunan Reaktor Vertikal Dan Horizontal Terhadap Penyisihan Cod Dan Tss Limbah Rumah Pemotongan Hewan Menggunakan Biofilter Aerob-anaerob Dengan Media Kerikil Hasil Gunung Merapi (Studi Kasus : Air Limbah Rumah Pemotongan Hewan Kota Salatiga)

The growing need for meat in Indonesia is directly proportional to the increase in population resulted in increased numbers of slaughter. Any increase in production means there is no increase in waste generated. One of the pollutants present in the slaughterhouse waste is organic solids from the liquid blood, the remaining fat, feces, and rumen contents . This study describes the study of the influence of vertical and horizontal arrangement of the reactor using an anaerobic-aerobic biofilter media gravel eruption of Mount Merapi in reducing COD and TSS The anaerob-aerob applies continous system and detention time. Detention time is determine 7 to 10 hours. The result of this research are degredation of 78,2 % COD and 95,95% TSS for vertical reactor composition and degradation of 77,92 % COD and 97,3 % TSS for horizontal composition. Conclusion is the vertical reactor is better degradation COD the horizontal reactor is better degradation TSS

TINGKAT KEHADIRAN DAN KENANEKARAGAMN JENIS MAMALIA DI AREAL REKLAMASI PT. BERAU COAL, KALIMANTAN TIMUR

Mining activities have a big impact to change environmental condition and biodiversity. The government, through its rules requires an environmental management process at mining site. PT. Berau Coal has a high commitment in efforts to improve the environment, it's proved by the revegetation and monitoring of reclamation areas that cariied out every year. This research aims to see the diversity of mammals in reclamation area as one indicator of the success of revegetation program carried out by PT. Berau Coal. This research conducted in 3 reclamation areas, Lati Site, Binungan Site, and Sambarata Site. Data that used are biodiversity monitoring from 2014 - 2017.  Some of analyzes used include Biodiversity Index (H') and Equity Index (E). The results showed that the presence of mammal in reclamation area was quite high with an average annual presence of 21 species in Lati Site, 21 species in Binungan Site, and 23 species in Sambarata Site. Whereas if viewed from the annual average number of individuals present were 70 individuals in Lati Site, 56 individuals in Sambarata Site, and 74 jndividuals im Binungan Site. This level of delivery provides a description that the reclamation area of PT. Berau Coal has able provide a good habitat for mammals. While the biodiversity values (H ') of mammals are at Lati 2.45; H 'in Binungan 2.67 and H' in sambarata 2.5

Valuasi Ekonomi Objek Wisata Berbasis Jasa Lingkungan Menggunakan Metode Biaya Perjalanan di Pantai Batu Karas Kabupaten Pangandaran

Batu Karas beach at Pangandaran Regency, West Java Province has the potential of natural beauties that can be used as an ecotourism object. The purpose of this study was to determine the economic value of environmental service-based tourism and to identify factors that contribute to the tourism demand to Batu Karas beach. Individual Travel Cost Method (ITCM) was used to estimate the potential economic value of tourism activity, and linear regression analysis was used to determine the influence factors of tourism demand. Data was obtained through questionnaires to respondents. The results showed that the most influential factors of the level of tourist demand to Batu Karas beach are travel cost, distance and duration in the location. The demand equation model based on travel cost method is Y = 1.766 0.000001887 X1 ; where Y= tourism demand and X1 = travel cost. Potential economic value of ecotourism in Batu Karas beach reached Rp 86,571,960,874.00 annually with a consumer surplus of Rp 566,183.00 per individual per year. Major economic benefits from tourism activities in Batu Karas beach brings socio-economic improvement of the local community

Исследование методом сетевой фармакологии и молекулярного докинга для выявления потенциальной противораковой активности морских цитотоксинов — осциллатоксинов D, E, и F

Oscillatoxins (OTXs) are cytotoxins produced by some marine cyanobacteria. Their unique structures show a great potency as an anticancer agent. The limited availability of OTX derivatives in nature provides little information about their biological activity. Some of OTX activities have been tested in the in vitro or in vivo studies toward cancer cell lines, but their exact mechanism of action on the target is unclear. In this study, we used the network pharmacology analysis method to predict the target and mechanism of action of oscillatoxin D (OTX-D), 30 methyl oscillatoxin D (30-methyl-OTX-D), oscillatoxin E (OTX-E), and oscillatoxin F (OTX-F). There are 20 possible targets of the four compounds toward cancer, and the main targets of them are PIK3CA, CDK1, and MTOR. This was also followed by the molecular docking study to understand the interaction between the four compounds and their targets. Molecular docking showed that the four compounds interacted well with the key targets. In this study, four derivatives of OTXs and their three key targets for the anticancer action were revealed suggesting multiple signaling pathways, including PD-L1 expression and PD‑1 checkpoint pathway in cancer, proteoglycans in cancer, and pathways in cancer, establishing a theoretical framework for the further experimental study.Осциллатоксины (OTXs) —  это цитотоксины, продуцируемые некоторыми морскими цианобактериями. Их уникальные структуры показывают высокую эффективность в качестве противораковых средств. Ограниченная доступность производных OTXs в природе дает мало информации об их биологической активности. Было тестировано несколько активностей OTXs в исследованиях in vitro или in vivo в отношении линий раковых клеток, но их точный механизм действия на мишень не ясен. В данном исследовании мы использовали метод сетевой фармакологии для прогнозирования мишеней и механизмов действия осциллатоксина D (OTX-D), 30 метил-осциллатоксина D (30-метил-OTX-D), осциллатоксина E (OTX-E), и осциллатоксина F (OTX-F). Существуют 20 возможных мишеней четырех соединений против рака и их основными мишенями являются PIK3CA, CDK1 и MTOR. Затем было проведено исследование методом молекулярного докинга для понимания взаимодействия между 4 соединениями и их мишенями. Молекулярный докинг показал, что 4 соединения хорошо взаимодействовали с ключевыми мишенями. В данной работе было выявлено 4 производных OTXs и 3 ключевых мишени для противоракового действия, указывая на множественные сигнальные пути, включая путь экспрессии PD-L1 и контрольной точки PD-1 при раке, протеогликаны при раке и пути при раке, устанавливая теоретические рамки для дальнейшего экспериментального исследования

PENIRAPAN ACTIYITY BASED COSTING SEBAGAI UPAYA UNTUK MENINGKATKAN AKURASI DALAM PENETAPAN HARGA POKOK JASA PENYAMAKAN KULIT (STUDI KASUS PADA PT. CARMA WIRA JATIM)

Penelitian ini merupakan deskriptiJ research dengan metode studi kasus pada PT. Canna Wira Jatim -Magetan dengan judul "Penenpan Activity-Based. Costing Sebagai Upaya Untuk Meningkatkan Akurui Dalam Penetapan Barga Pokok Jasa Penyamakan Knlit Pada PT. Carma Win Jatim." Tujuan penelitian ini adalah untuk mengetahui bagaimana penerapan Activity-Based Costing Sebagai Upaya Untuk Meningkatkan Akurasi Dalam Penetapan Harga Pokok Jasa Penyamakan Kulit Pada PT. Canna Wira Jarim. Pada PT. Cama Wira Jatim, dalam perhitungan biaya jasa penyamakan kulit masih menggunakan sistem konvensional (plant Wide Rates) dalam membebankan biaya overheadnya yaitu berdasarkan jam kerja langsung. Perhitungan ini memiliki kelemahan dalam keak:uratan dalam penetapan harga pokok produk &tau jasa, sehingga diperlukan suatu sistem yang dapat meningkatkan keakuratan dalam perhitungan biaya produk yaitu dengan menerapkan ABC system. Penelitian ini membahas perbedaaan antara perhitungan biaya jasa penyamakan kulit antara penggunaan sistem konvensional (plant wide rates) dengan ABC system, dimana dalam pembahasan yang telah dilakukan sistem ABC dapat memberikan informasi yang lebih akurat tentang perhitungan biaya jasa penyamakan kulit. Berikut ini hasil perhitungan biaya jasa penyamakan kulit untuk jasa wet picled apabila menggunakan sistem konvensional diperoleb biaya jasa perlembar sebesar Rp. 1.118,57 sedangkan menggunakan ABC system sebesar Rp. 1.079,67 dan untuk jasa wet blue dengan sistem konvensional dibasilkan Rp. 1.313,49 sedangkan bila berdasarkan ABC system akan dihasilkan Rp. 1.385,85. Berdasarkan perhitungan biaya jasa perlembar yang telah dilakukan terjadi selisih pada masing-masing jenis jasa penyamakan kulit, hal ini dikarenakan perbedaan alokasi overhead dan pembebanan aktivitas produksi pada masing-masing jenis jasa penyamakan kulit. Berdasarkan basil penelitian, disarankan perusahaan sebaiknya menggunakan ABC system dalam perhitungan biaya jasa penyamakan kulitnya namun hal ini juga harus didasari dengan syarat bahwa penerapan ABC system akan efektif bila prosentase biaya overhead terhadap total biaya produksi sebesar 40010

Analisa Faktor €“ Faktor E-Commerce dalam Membentuk Customer Satisfaction Millenial Bukalapak

Penerapan teknologi informasi menjadi suatu kebijakan Perusahaan telah menjadi keharusan. Dalam hal ini penerapan e-commerce sangat menunjang kegiatan usaha Perusahaan dalam meningkatkan pelayanan kepada konsumen. Penelitian ini bertujuan untuk mengetahui faktor apa yang paling dominan dari e-commerce yangmempengaruhi kepuasan konsumen millennial bukalapak.  Selain itu, penelitian ini menjawab hipotesis, apakah ada pengaruh dimensi-dimensi e-commerce baik secara partial maupun simultan terhadap customer satisfaction.  Penelitian ini menggunakan pendekatan metode analisis regresi linear berganda dengan mengambil 40 sampel.  Kuesioner digunakan sebagai instrument penelitian.  Kesimpulan yang diambil dalam penelitian ini adalah dari ketiga dimensi E-Commerce ternyata EC3 (perdagangan dengan sistem pertukaran data) mempunyai pengaruh dominan terhadap kepuasan konsumen bukalapak; dalam pengujian hipotesis secara partial dapat disimpulkan bahwa H3 diterima sedangkan hipotesis H2 dan H1, keduanya ditolak, sedangkan secara bersama-sama seluruh dimensi E-commerce berpengaruh terhadap kepuasan konsumen.   Kata Kunci:Kepuasan konsumen, millenial, E-commerce, Customer Satisfactio