Aqueous Et₄NBrO₃/KBr as a versatile and environmentally benign source of bromine for the selective <i style="mso-bidi-font-style:normal">trans</i>-bromination of alkenes

802-806An aqueous solution of tetraethyl ammonium bromate and potassium bromide is found to be an environmentally benign source of bromine at ambient temperature. This reagent is used for selective trans-dibromination of several substituted alkenes. The reaction conditions are mild and the yield of the products are high and other possible by-products such as bromohydrin formation and aromatic substitution have not been observed

<span style="font-size:10.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Mangal; mso-ansi-language:EN-IN;mso-fareast-language:EN-US;mso-bidi-language:HI">Tetraalkylammonium bromate (TAAB) catalyzed cyclodehydration: A facile synthesis of 2,3-dihydro-1<i>H</i>-1,5-benzodiazepine in aqueous methanol</span>

1123-1127<span style="font-size:10.0pt;font-family: " times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-US">A simple and convenient method is reported for the synthesis of 2,3-dihydro-1H-1,5-benzodiazepine from o-phenylene-diamine and ketones in aqueous methanol using IL, tetraalkylammonium bromate, as the cyclodehydration catalyst. The synthetic protocol is simple and reaction accomplished at ambient temperature. Yields are good and work up easy.</span

Tetraethylammonium bromate mediated synthesis of 2-arylbenzothiazole

1214-1217A simple and convenient method is described for the synthesis of 2-arylbenzothiazoles mediated by quaternary ammonium bromate at room temperature. Short reaction time at ambient temperature, high yield of the product and simple product recovery are the chief features of the present method

Clinical and histopathological profile of lupus nephritis and response to treatment with cyclophosphamide: A single center study

Lupus nephritis (LN) is an immune-complex glomerulonephritis that is usually manifested by proteinuria, active urinary sediment, hypertension, and renal failure. The objective of this study is to study the clinical and histopathological profile of LN and the response to treatment with cyclophosphamide. This was a retrospective study conducted in a tertiary care center in Assam, India, where 176 LN patients who underwent renal biopsy were included. The presenting features, laboratory parameters such as proteinuria, hematuria, and the histopathological class of the patients were studied. Among the 176 patients, 89.8% were female and 10.2% were male and maximum patients (61.3%) were in the age group of 20–40 years. Pedal edema was present in 100% of the patients, decreased urine output in 43.7%, malar rash in 38%, joint pain in 42%, hair loss in 63%, hypertension in 41.4%, oral ulcers in 31.8%, seizures in 17%, psychosis in 13%, hematuriain 78.4%, anemia in 72.1%, thrombocytopenia in 51.1%, and leukopenia in 31.7% of patients. The anti-nuclear antibody was positive in all patients and anti-dsDNA was positive in 70.5% of the patients. The most common histopathological type was class IV (50%), followed by class III (17.6%). One hundred and two patients received intravenous cyclophosphamide as initial treatment of whom, 40 received the Eurolupus regimen and 62 received the NIH regimen. The number of patients who underwent remission in both the regimen was compared. The response rate of initial treatment with cyclophosphamide in the Eurolupus group was 62.5% and in the NIH group was 64.5% (P >0.05). Majority of the patients had proliferative LN in this study, of which class IV was the most common. Proliferative LN, if not detected and treated early, leads to poor outcome in terms of patient and renal survival. Hence, patients with systemic lupus erythematosus should be evaluated for kidney involvement and treated accordingly for better outcome

Regeneration of the carbonyl compounds from their semicarbazones using tetra-<i style="">n</i>-alkylammonium bromates

2157-2160Tetra alkyl ammonium bromates are prepared by a simple procedure and used for the oxidative regeneration of the parent carbonyl compound from their semicarbazones. Reaction conditions are simple and the deprotection gives satisfactory yield of the carbonyl compound

Does classical immunity acquired by the subcontinent population become advantageous to manage COVID-19 due to the low rate of mortality?

The global pandemic due to the COVID-19 has severely affected the entire world risking human life and economy. Every possible attempt becomes inadequate in controlling the disease as the number rising each passing day. Indeed, a highly populated country like India has so far successful in mitigating the outbreak within the country. Meanwhile, the strategy based on a preliminary model of assumption with massive awareness program on social (physical) distancing, compulsory wearing of a mask and nationwide lockdown might have contributed immensely to controlling such an emergency. However, the influence of the immune-competent genetic architecture of the Indian racing population and comparatively a dominant young age group population cannot be ruled out completely. Moreover, a suitable environment for viral propagation and characteristics of viral strain are other such factors that simultaneously could add a real scientific justification. However, the current global scenario indicating the countries with higher median age are severely affected compared to the Indian and African subcontinent thereby survived an outbreak with a low mortality rate. At the same time, we never claimed for complete immunity for the COVID-19 depending on age or immunity. The increased incidence of positive cases might slowly also increase the death rate within India, but so far recorded low compared to other parts of the globe.&nbsp;</p