18 research outputs found
Community-led initiatives’ everyday politics for sustainability – Conflicting rationalities and aspirations for change?
This project has received funding from the European Union’s 7th Framework Programme for Research, Technological Development and Demonstration (Grant Agreement no. 603705) through TESS (Towards European Social Sustainability, http://www.tess-transition.eu/).Community-based initiatives are widely seen to play an essential role in a societal move towards a low carbon, sustainable future. As part of this, there is often an assumption that such initiatives share expectations (i.e. a guiding vision) of large-scale change and that their activities contribute to this change. Here, we ask to what extent this assumption reflects members’ own perspectives on and interpretations of the aims and ambitions of their community initiative, and what this implies for a larger vision of sustainability transitions. In doing so, we respond to calls for a better understanding of the ‘everyday politics’ of what could be seen as processes of societal transitions in practice. We conducted qualitative interviews with members of five community initiatives in Italy, Finland and the UK. In each of these initiatives, we found a range of aspirations (i.e. outcome-related aims) and rationalities (i.e. procedural guiding principles). While some of these aims and ways of working were compatible with each other, we identified three major tensions that could be found across our study initiatives. These tensions centred on (i) the degree of politicisation of the initiative, (ii) the extent to which financial aims should take priority and (iii) questions of organisational form. We interpret these tensions as conflicting expressions of larger, societal-level discourses, and argue that this diversity and resulting conflicts need to be acknowledged – both in transition research and at the practical level – to avoid co-optation and disenfranchisement.PostprintPeer reviewe
Eumelanin broadband absorption develops from aggregation-modulated chromophore interactions under structural and redox control
Eumelanins, the chief photoprotective pigments in man and mammals, owe their black color to an unusual broadband absorption spectrum whose origin is still a conundrum. Excitonic effects from the interplay of geometric order and disorder in 5,6-dihydroxyindole (DHI)-based oligomeric/polymeric structures play a central role, however the contributions of structural (scaffold-controlled) and redox ( €-electron-controlled) disorder have remained uncharted. Herein, we report an integrated experimental-theoretical entry to eumelanin chromophore dynamics based on poly(vinyl alcohol)-controlled polymerization of a large set of 5,6-dihydroxyindoles and related dimers. The results a) uncover the impact of the structural scaffold on eumelanin optical properties, disproving the widespread assumption of a universal monotonic chromophore; b) delineate eumelanin chromophore buildup as a three-step dynamic process involving the rapid generation of oxidized oligomers, termed melanochromes (phase I), followed by a slow oxidant-independent band broadening (phase II) leading eventually to scattering (phase III); c) point to a slow reorganization-stabilization of melanochromes via intermolecular redox interactions as the main determinant of visible broadband absorption
Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia
Community-led initiatives’ everyday politics for sustainability – Conflicting rationalities and aspirations for change?
Community-based initiatives are widely seen to play an essential role in a societal move towards a low carbon, sustainable future. As part of this, there is often an assumption that such initiatives share expectations (i.e. a guiding vision) of large-scale change and that their activities contribute to this change. Here, we ask to what extent this assumption reflects members’ own perspectives on and interpretations of the aims and ambitions of their community initiative, and what this implies for a larger vision of sustainability transitions. In doing so, we respond to calls for a better understanding of the ‘everyday politics’ of what could be seen as processes of societal transitions in practice. We conducted qualitative interviews with members of five community initiatives in Italy, Finland and the UK. In each of these initiatives, we found a range of aspirations (i.e. outcome-related aims) and rationalities (i.e. procedural guiding principles). While some of these aims and ways of working were compatible with each other, we identified three major tensions that could be found across our study initiatives. These tensions centred on (i) the degree of politicisation of the initiative, (ii) the extent to which financial aims should take priority and (iii) questions of organisational form. We interpret these tensions as conflicting expressions of larger, societal-level discourses, and argue that this diversity and resulting conflicts need to be acknowledged – both in transition research and at the practical level – to avoid co-optation and disenfranchisement
Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients
AbstractObjective To evaluate the effects of alpha lipoic acid (ALA) on hormonal and metabolic parameters in a group of overweight/obese Polycystic Ovary Syndrome (PCOS) patients.Methods This was a retrospective study in which thirty-two overweight/obese patients with PCOS (n = 32) not requiring hormonal treatment were selected from the database of the ambulatory clinic of the Gynecological Endocrinology Center at the University of Modena and Reggio Emilia, Italy. The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of complementary treatment with ALA (400 mg/day). Hepatic Insulin Extraction (HIE) index was also calculated.Results ALA administration significantly improved insulin sensitivity and decreased ALT and AST plasma levels in all subjects, though no changes were observed on reproductive hormones. When PCOS patients were subdivided according to the presence or absence of familial diabetes background, the higher effects of ALA were observed in the former group that showed AST and ALT reduction and greater HIE index decrease.Conclusion ALA administration improved insulin sensitivity in overweight/obese PCOS patients, especially in those with familial predisposition to diabetes. ALA administration improved both peripheral sensitivity to insulin and liver clearance of insulin. Such effects potentially decrease the risk of nonalcoholic fat liver disease and diabetes in PCOS patients
Identificazione di un profilo di espressione genica associato a danno d’organo vascolare tramite oligorna-microarrays in linfomonociti circolanti.
Community-led initiatives’ everyday politics for sustainability – Conflicting rationalities and aspirations for change?
Identificazione di un profilo di espressione genica associato a danno d’organo vascolare tramite oligorna-microarrays in linfomonociti circolanti.
Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: a cross-sectional study
Aims: Individuals with type 2 diabetes show shorter leukocyte telomere length (LTL) compared to people without diabetes. Reduced LTL is associated with increased carotid intima-media thickness (IMT) in healthy subjects. The aim of the study is to assess whether LTL also correlates with IMT in patients with diabetes. Methods: In a cohort of 104 subjects with type 2 diabetes and atherogenic dyslipidemia, we assessed anthropometric, hemodynamic and metabolic parameters. Common carotid IMT was expressed as the maximum IMT. LTL was assessed by a specific real-time PCR reaction. Results: At univariate analysis, IMT values were positively correlated with age (p < 0.001), previous history of cardiovascular events (p < 0.005), fasting plasma glucose (p < 0.01), HbA1c (p < 0.05) and negatively correlated with LTL (p < 0.05). In a multivariate model, age (p < 0.001) and LTL (p < 0.05) were the only independent predictors of maximum IMT, with an adjusted R2 of 0.22. Conclusions: LTL is an independent predictor of subclinical atherosclerosis pointing to a role of LTL as an early marker of vascular burden and cardiovascular disease also in type 2 diabetes
Application of Hyperspectral Imaging to Underwater Habitat Mapping, Southern Adriatic Sea
Hyperspectral imagers enable the collection of high-resolution spectral images exploitable for the supervised classification of habitats and objects of interest (OOI). Although this is a well-established technology for the study of subaerial environments, Ecotone AS has developed an underwater hyperspectral imager (UHI) system to explore the properties of the seafloor. The aim of the project is to evaluate the potential of this instrument for mapping and monitoring benthic habitats in shallow and deep-water environments. For the first time, we tested this system at two sites in the Southern Adriatic Sea (Mediterranean Sea): the cold-water coral (CWC) habitat in the Bari Canyon and the Coralligenous habitat off Brindisi. We created a spectral library for each site, considering the different substrates and the main OOI reaching, where possible, the lower taxonomic rank. We applied the spectral angle mapper (SAM) supervised classification to map the areal extent of the Coralligenous and to recognize the major CWC habitat-formers. Despite some technical problems, the first results demonstrate the suitability of the UHI camera for habitat mapping and seabed monitoring, through the achievement of quantifiable and repeatable classifications