Drug utilization pattern of antiseizure drugs and their adverse effects in the pediatric population, in a tertiary care hospital attached to a medical college

Background: Epilepsy is “a condition characterized by recurrent (two or more) seizure, unprovoked by any immediate identified cause.” The desired outcome of antiseizure drug (ASD) therapy is to be seizure-free throughout the rest of life. The objective was to study the utilization pattern and adverse drug reactions (ADRs) associated with the use of ASDs in pediatric outpatients in epilepsy clinic.Methods: This cross-sectional, observational and single center study was carried out over a period of 1 year in 430 pediatric patients. Analyzed data included demographic details and drugs prescribed in respective seizure types along with ADRs due to ASDs. Results: In a total 430 patients analyzed, seizure were most commonly observed in boys (69.8%) in 6-10 year of age (45.3%), with a positive family history in (16%), with no specific cause of seizure in (71.6%), with most common type was focal seizure in (62.3%), which was mainly treated with carbamazepine (73.8%). Most common ADR was irritability (32.2%) with Valproate being main drug. 87.3% ADRs were in “ possible” as per World Health Organization causality assessment scale, 94.9% ADRs were “mild” as per Hartwig and Siegel severity assessment scale and 98.3% ADRs were “preventable” as per Schumock and Thornton preventability scale.Conclusion: Focal seizure was most common type of seizure observed mainly in boys of 6-10 year with carbamazepine as mainly prescribed drug. Use of appropriate ASDs in the majority of patients as per guidelines, has decreased number of ADRs in our study. Prescribing drugs were mainly from essential drug list and by generic names

Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.

Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance, driven largely by target-based mutations in the GyrA/ParC quinolone resistance determining region, have eroded the utility and threaten the future use of this vital class of antibiotics. Herein we describe the discovery and optimization of a series of 4-(aminomethyl)quinolin-2(1H)-ones, exemplified by 34, that inhibit bacterial DNA gyrase and topoisomerase IV and display potent activity against ciprofloxacin-resistant Gram-negative pathogens. X-ray crystallography reveals that 34 occupies the classical quinolone binding site in the topoisomerase IV-DNA cleavage complex but does not form significant contacts with residues in the quinolone resistance determining region

On generalized fractional kinetic equations involving generalized Lommel-Wright functions

Fractional kinetic equations play an important role in certain astrophysical problems. In this paper, authors have established further generalization of fractional kinetic equations involving generalized Lommel-Wright functions. Solutions of these generalized fractional kinetic equations were obtained in terms of Mittag–Leffler function using Laplace transform. Some special cases also contain the generalized Bessel function and Struve function

Fractional calculus approach to study temperature distribution within a spinning satellite

This paper deals with the temperature distribution within spinning satellites and problem is formulated in terms of fractional differential equation. Applying fractional calculus approach, solution of this equation is obtained in terms of Wright generalized hypergeometric function, a generalization of exponential function

Treatment outcome of patients having extensively drug-resistant tuberculosis in Gujarat, India

Background: To investigate the factors affecting treatment outcome of extensively drug resistant tuberculosis (XDR-TB) in Gujarat, India. Methods: A prospective, observational study was conducted on patients with XDR TB from January 2012 to October 2016. Details of demography, clinical symptoms, sputum/culture and radiological examination, drug treatment, adverse drug reactions (ADRs) and treatment outcome were recorded in pretested case record form (CRF). Data was analyzed using Fisher's exact test and paired student's t test. Results: Out of 112 patients, 83 (74%) were men and 29 (26%) were women and majority of belonged to age group of 16 – 45 years. Majority of patients (79%) received standardized treatment. A total of 61 (54%) patients converted to sputum culture negative by 12 months and out of these, 49 turned sputum culture negative within initial 6 months of treatment. Successful treatment outcome was seen in 29 (25.89 %). Age ≤40 years (P 18.5 (P<0.05) and sputum/culture conversion at three month (P<0.001) were positive predictors for successful treatment outcome, while tobacco chewing habit (P<0.05) and alcohol consumption (P<0.05) were negative predictors for the successful treatment outcome. Out of 83 (74.1 %) patients with unsuccessful treatment outcome, 58 (51.78 %) died, 11 (9.82 %) were defaulter and 10 (8.92 %) were treatment failure. Factors positively associated with death were very low BMI (< 18.5), concomitant diseases and harmful personal habits. Conclusions: Treatment outcome of XDR TB patients is extremely poor with high mortality rate

Experimental and CFD analysis on heat transfer and fluid flow characteristic of a tube equipped with variable pitch twisted tape

In this paper, we report an experimental and Computational Fluid Dynamics (CFD) investigation on the overall heat transfer coefficient, friction factor and effectiveness of a tube equipped with classic and variable twisted tape inserts. Constant (Y = 4.0) and variable pitch twisted inserts (Y = 4-3-4) made of Stainless Steel and Aluminium were used during the experiments due to their ease in machinability. Resistance thermometers were used to measure temperature of the working fluid at the inlet and outlet of the test section. It was observed that the twisted tape in the tube imposes the turbulence in the fluid and enhances the heat transfer due to swirling flow. The results showed that the overall heat transfer coefficient and effectiveness of aluminium variable pitch twisted tape were higher than stainless steel inserts. The experimental data obtained were validated using Computational Fluid Dynamics (CFD) simulations. The constant pitch inserts for aluminium and stainless steel showed an enhancement of 67.54% and 66.65% as compared to plain tube. Whereas aluminium variable pitch inserts showed an enhancement of overall heat transfer coefficient by 18.15% as compared to constant pitch insert and stainless-steel variable pitch insert showed enhancement of 15.25% as compared to constant pitch insert

Spiders (Arachnida: Araneae) of Gujarat University Campus, Ahmedabad, India with additional description of Eilica tikaderi (Platnick, 1976)

We report a checklist of spiders based on a survey made from August 2013 to July 2014 in Gujarat University Campus, an urban area located in the middle of Ahmadabad City, Gujarat State. A total of 77 species of spiders belonging to 53 genera and 20 families of spiders were recorded from the study area represented by 31.74% of the total 63 families reported from India. Salticidae was found to be the most dominant family with 18 species from 14 genera. Guild structure analysis revealed six feeding guilds, namely stalkers, orb-web builders, space-web builders, ambushers, foliage hunters and ground runners. Stalkers and orb-web builders were the most dominant feeding guilds representing 28.58% and 20.78% respectively among all studied guilds. Species Eilica tikaderi (Platnick, 1976) is reported for the first time from Gujarat with additional description and detailed genitalic illustrations