Ion Write Microthermotics: Programing Thermal Metamaterials at the Microscale.

Considerable advances in manipulating heat flow in solids have been made through the innovation of artificial thermal structures such as thermal diodes, camouflages, and cloaks. Such thermal devices can be readily constructed only at the macroscale by mechanically assembling different materials with distinct values of thermal conductivity. Here, we extend these concepts to the microscale by demonstrating a monolithic material structure on which nearly arbitrary microscale thermal metamaterial patterns can be written and programmed. It is based on a single, suspended silicon membrane whose thermal conductivity is locally, continuously, and reversibly engineered over a wide range (between 2 and 65 W/m·K) and with fine spatial resolution (10-100 nm) by focused ion irradiation. Our thermal cloak demonstration shows how ion-write microthermotics can be used as a lithography-free platform to create thermal metamaterials that control heat flow at the microscale

RF Energy Harvesting For Self Powered Sensor Platform

This work demonstrates a RE powered sensor platform where energy can be available either in ambient FM band or emitted from a dedicated RF source. We realized the requirement with a dedicated chip built for RF power harvesting and conditioning A switched capacitor based ultra low power DC-DC boost converter is designed in 130nm CMOS technology as energy harvesting circuitry for ambient RF. The on-chip RE-DC resulted in a maximum efficiency of 44% with 9.75k Omega resistive load. At input sensitivities of -16dBm over 8 dominant frequencies, the sensor platform with strain gauge as sensor advertised a BEE packet every 20 minutes. For dedicated emitted radiations, the designed hybrid system is powered using sub-1 GHz frequencies. The resulting system has an end-to-end system efficiency of 9.1% and packet transmission interval of 90 seconds

Role of perfusion CT in the evaluation of adnexal masses

The objective of this study was to evaluate the role of perfusion computed tomography (PCT) in differentiating benign from malignant adnexal masses. Twenty patients, each of pathologically proven malignant and benign adnexal masses who had undergone PCT on 64–slice CT scanner, were included in the study. The PCT parameters, viz. blood volume (BV), blood flow (BF), permeability surface index area (PS) and time to maximum of the tissue residue function (Tmax) of the adnexal masses were calculated. Statistical analysis to study the association between PCT parameters and histopathological diagnosis was done. In the malignant group, the mean PS, BV and BF values were elevated. The mean Tmax of the benign lesions was higher compared to that of the malignant lesions. There was a significant statistical difference in the PCT parameters between the malignant and benign groups (p value = .001). PCT can be a useful tool for differentiating benign and malignant adnexal masses.Impact statement What is already known on this subject? It is not always possible to distinguish benign from malignant adnexal lesions despite the application of various imaging techniques. Perfusion CT (PCT) is an imaging technique with which we can obtain both the morphological and functional information of tumours. Perfusion-based imaging enables us to objectively evaluate the neovascularity in a lesion. This helps in differentiating the benign lesions from aggressive malignant lesions. What do the results of this study add? The PCT parameters, viz. blood volume (BV), blood flow (BF), permeability surface index area (PS) and time to maximum of the tissue residue function (Tmax) were calculated from adnexal masses on a 64–multi-slice CT scanner and correlated with their histopathological diagnoses. The values of the mean PS, BV and BF values were significantly higher in the malignant adnexal masses. The mean Tmax in the benign masses was more compared to that of the malignant lesions. Significant statistical difference was seen in PCT parameters between malignant and benign groups. What are the implications of these findings for clinical practice and/or further research? PCT can be a useful tool for differentiating benign from malignant adnexal masses. However, more collaborative research and robust validation are imperative to further evaluate this innovative evolving technique

The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis

Background: The pro-apoptotic protein Siva-1 functions in both extrinsic and intrinsic cell death signaling; however, the exact contribution of the endogenous Siva-1 to DNA damage-induced apoptosis is unclear. Using cisplatin, a chemotherapeutic drug, to induce DNA damage and cell death, we determined the role of Siva-1. Methods: Cisplatin treated HCT116 colorectal carcinoma cells (p53+/+ and -/-) were used in the study. With the help of recombinant lentivirus that can express siSiva (siRNA that specifically targets Siva-1), we also generated Siva-1 knockdown HCT116 cells. Apoptosis was determined by tetramethyl rhodamine methyl ester (TMRM) staining and propidium iodide (PI) staining. Results: Treatment with cisplatin induced Siva-1 expression in a p53 dependent manner. In Siva-1 knockdown p53+/+ HCT116 colorectal carcinoma cells, loss of Siva-1 expression conferred significant resistance to cisplatin-induced apoptosis. Although Siva-1 levels were positively regulated by p53, Siva-1-induced apoptosis did not require p53. Despite the fact that Siva-1 lacks even a minimal BH3 domain, similar to other proapoptotic Bcl2 family members induced by p53, we showed that Siva-1 mediated apoptosis is characterized by Bax oligomerization and cytochrome c leakage from mitochondria. The putative amphipathic helical region in Siva-1 (SAH) appeared to function analogously to a BH3 domain. Conclusion: The p53 induced Siva-1 is one of the effector molecules, which plays a significant role in DNA damage-induced cell death

Rural Transformation of a Village in Telangana, A Study of Dokur since 1970s

The structural changes taking place in villages are partly due to market forces and also because of public policy. The article examines the transformation and development of a village namely Dokur in Telangana, India which has undergone changes since mid-1970s. The village was initially studied in 1975–1984 by the International Crops Research Institute for Semi-Arid Tropics (ICRISAT), but resurveyed from 2001 to 2014. There has been seen a significant change since 1980s in its livelihood diversity. Until the mid-1970s, there was more focus on green revolution technologies under the assumption that the trickle-down effect would take care of poverty. Hence, in the initial years, very few development programmes existed and were mostly focused on agriculture growth. Although public distribution system was in place from the mid 1970s, a new government initiative targeted poverty directly through a 20-point plan. From the 1990s, more specific schemes were introduced, which often targeted poor, scheduled castes and tribes (SC and ST) and other backward castes (OBC) as well as small and marginal farmers also. After realizing that most of the benefits were captured by village elites and large farmers, the focus shifted to self-targeting of various developments and social safety net programmes targeting lower castes and poorer households in the late 2000s, especially after the introduction of Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA). This was also an attempt to reduce gender bias in the programmes. The participation of poor, SC and ST and women increased after the self-targeting schemes were introduced in the country. The Public Distribution System (PDS), Indira Awas Yojana (IAY), pension schemes, complete sanitation programmes, agricultural input subsidy programme, million wells programmes, loan waiver scheme and the drought relief programmes had positive impacts on livelihoods, but with less targeting. Most of the gains from agricultural subsidies were enjoyed by medium and large farmers, although small SC and ST farmers benefited some what. However, all indicators show a systematic and considerable increase in living standards

The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis

Background: The pro-apoptotic protein Siva-1 functions in both extrinsic and intrinsic cell death signaling; however, the exact contribution of the endogenous Siva-1 to DNA damage-induced apoptosis is unclear. Using cisplatin, a chemotherapeutic drug, to induce DNA damage and cell death, we determined the role of Siva-1. Methods: Cisplatin treated HCT116 colorectal carcinoma cells (p53+/+ and -/-) were used in the study. With the help of recombinant lentivirus that can express siSiva (siRNA that specifi cally targets Siva-1), we also generated Siva-1 knockdown HCT116 cells. Apoptosis was determined by tetramethyl rhodamine methyl ester (TMRM) staining and propidium iodide (PI) staining. Results: Treatment with cisplatin induced Siva-1 expression in a p53 dependent manner. In Siva-1 knockdown p53+/+ HCT116 colorectal carcinoma cells, loss of Siva-1 expression conferred signifi cant resistance to cisplatin-induced apoptosis. Although Siva-1 levels were positively regulated by p53, Siva-1-induced apoptosis did not require p53. Despite the fact that Siva-1 lacks even a minimal BH3 domain, similar to other proapoptotic Bcl2 family members induced by p53, we showed that Siva-1 mediated apoptosis is characterized by Bax oligomerization and cytochrome c leakage from mitochondria. The putative amphipathic helical region in Siva-1 (SAH) appeared to function analogously to a BH3 domain. Conclusion: The p53 induced Siva-1 is one of the effector molecules, which plays a significant role in DNA damage-induced cell death