Contaminazioni visive. Dal censimento al sistema. Arte e architettura tra chiesa e territorio a Bologna

A partire dal censimento condotto sul patrimonio, architettonico e decorativo, degli edifici di culto della Diocesi di Bologna, le autrici, in qualità di schedatrici, presentano alcune vie d’analisi critica sul materiale raccolto per i relativi ambiti disciplinari. Dopo il censimento pubblicato da Enrico Corty (1844), ancora oggi fondamentale riferimento per qualsiasi indagine preliminare sulle chiese della Diocesi, quella in corso si rivela la prima esperienza in grado di fotografare la reale consistenza del patrimonio ecclesiastico bolognese. A differenza dei lavori ottocenteschi e di primo novecento, si vuole mettere in luce come l’operazione attuale abbia dato forma ad un nuovo sistema di raccolta dei dati provenienti dal territorio felsineo, compatibile con le attuali metodologie di indagine storico artistica e conservativa dei manufatti e delle opere d’arte, nonché con le attuali esigenze di programmazione del destino di queste ultime. Costruendo un intervento a quattro mani e chiamando in causa le differenti analisi sul patrimonio architettonico e su quello storico artistico, si presenteranno alcuni case studies, volgendo attenzione a edifici e complessi decorativi scarsamente indagati del territorio della Diocesi

Affordance Theory in the IS Discipline: a Review and Synthesis of the Literature

International audienc

The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome

Myeloproliferative neoplasms are hematologic malignancies typified by a substantial heritable component. Germline variants may affect the risk of developing a MPN, as documented by GWAS studies on large patient cohorts. In addition, once the MPN occurred, inherited host genetic factors can be responsible for tuning the disease phenotypic presentation, outcome, and response to therapy. This review covered the polymorphisms that have been variably associated to MPNs, discussing them in the functional perspective of the biological pathways involved. Finally, we reviewed host genetic determinants of clonal hematopoiesis, a pre-malignant state that may anticipate overt hematologic neoplasms including MPNs

Visual influences, from the census to a system Art and architecture between “church” and “territory” in Bologna

Starting from the census conducted on Bolognese churches and their architectural and artistic heritage, the authors introduces some critical analysis on the picked material for each area of interest. After the census published by Henry Corty (1844), fundamental reference for any preliminary investigation on the Diocese churches till today, this is the first experience able to evaluate the real scope of ecclesiastical Bolognese patrimony. Unlike the nineteenth-century studies, they want to show how the currenty research has founded a new system of data collection on the Bolognese surrounding, compatible with the actual methodologies of historical artistic investigation and artworks conservation, as well as the actual demands about their destination. In this four-handed paper, some case studies, focused on little known buildings and decorative complexes, will be submitted. The intersection among architectural, decorative and liturgical data reveal unpublished relationship between visual languages and new system connecting “church” and “territory”

Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes

We discuss the case of synchronous bilateral lung cancers which feature the same histological phenotype and a different EGFR mutational profile. Both histological and molecular characterizations were performed on specimens derived thorough CT-guided fine needle aspiration. A first-line chemotherapy was unsuccessful. Subsequent objective response to the EGFR inhibitor Erlotinib was clearly coherent with the sequencing data and the mutated nodule was effectively reduced (> 50%) after therapy, while the lesion assessed as EGFR wild type featured a slight response. This report has two relevant implications. It points out that in case of multiple malignant lesions at time of diagnosis, molecular profiling should be as extensive as possible and it might contribute to clarify the association between the lesions found. Besides the molecular analysis on cytology specimens could identify an accurate and safe diagnostic approach for clinical use

EEG-based cognitive control behaviour assessment: an ecological study with professional air traffic controllers

Several models defining different types of cognitive human behaviour are available. For this work, we have selected the Skill, Rule and Knowledge (SRK) model proposed by Rasmussen in 1983. This model is currently broadly used in safety critical domains, such as the aviation. Nowadays, there are no tools able to assess at which level of cognitive control the operator is dealing with the considered task, that is if he/she is performing the task as an automated routine (skill level), as procedures-based activity (rule level), or as a problem-solving process (knowledge level). Several studies tried to model the SRK behaviours from a Human Factor perspective. Despite such studies, there are no evidences in which such behaviours have been evaluated from a neurophysiological point of view, for example, by considering brain activity variations across the different SRK levels. Therefore, the proposed study aimed to investigate the use of neurophysiological signals to assess the cognitive control behaviours accordingly to the SRK taxonomy. The results of the study, performed on 37 professional Air Traffic Controllers, demonstrated that specific brain features could characterize and discriminate the different SRK levels, therefore enabling an objective assessment of the degree of cognitive control behaviours in realistic setting

Targeting EGFR in non-small-cell lung cancer: Lessons, experiences, strategies

SummaryCancer is a genetic disease and this concept is now widely exploited by both scientists and clinicians to design new targeted molecules. Indeed many data have already allowed us to ameliorate not only our knowledge about cancer onset, but also about patients treatment. Correlation between mutations in cancer alleles and drug response is a key point to identify drugs that match the genetic profile of each individual tumors. On the other hand, experience derived from inhibition of tyrosine kinase receptors has pointed out that targeted treatment is really successful only in a small subset of tumors. The latter are eventually addicted to those genetic alterations which are responsible for receptors activation and for the continued expression of their signalling. Overall these observations provide a strong rationale for a molecular-based diagnosis and patients selection for targeted therapies.This review analyses the current state of the art of molecularly-tailored pharmacological approach to lung cancer, one of the biggest killers among human solid tumors. Main relevance is addressed to genetic lesions activating the EGFR pathway transducers, focusing on their role as markers of targeted drug response

Ethidium bromide as a marker of mtDNA replication in living cells.

Mitochondrial DNA (mtDNA) in tumor cells was found to play an important role in maintaining the malignant phenotype. Using laser scanning confocal fluorescence microscopy (LSCFM) in a recent work, we reported a variable fluorescence intensity of ethidium bromide (EB) in mitochondria nucleoids of living carcinoma cells. Since when EB is bound to nucleic acids its fluorescence is intensified; a higher EB fluorescence intensity could reflect a higher DNA accessibility to EB, suggesting a higher mtDNA replication activity. To prove this hypothesis, in the present work we studied, by LSCFM, the EB fluorescence in mitochondria nucleoids of living neuroblastoma cells, a model system in which differentiation affects the level of mtDNA replication. A drastic decrease of fluorescence was observed after differentiation. To correlate EB fluorescence intensity to the mtDNA replication state, we evaluated the mtDNA nascent strands content by ligation-mediated real-time PCR, and we found a halved amount of replicating mtDNA molecules in differentiating cells. A similar result was obtained by BrdU incorporation. These results indicate that the low EB fluorescence of nucleoids in differentiated cells is correlated to a low content of replicating mtDNA, suggesting that EB may be used as a marker of mtDNA replication in living cells. © 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)