Application of Focal Conflict Theory to Psychoeducational Groups: Implications for Process, Content, and Leadership

Group psychoeducation is a common group type used for a range of purposes. The literature presents balancing content and process as a challenge for psychoeducational group leaders. While the significance of group psychoeducation is supported, practitioners are given little direction for addressing process in these groups. Focal Conflict Theory (FCT) is a model for conceptualizing and intervening in group process that has been applied to therapy and work groups. This article presents the challenges of psychoeducational groups, describes FCT, and discusses its application to psychoeducational groups using case examples. Implications for leaders of psychoeducation groups are discussed

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Expressing and Enforcing Location Requirements in the Cloud Using Information Flow Control

The adoption of cloud computing is increasing and its use is becoming widespread in many sectors. As cloud service provision increases, legal and regulatory issues become more significant. In particular, the international nature of cloud provision raises concerns over the location of data and the laws to which they are subject. In this paper we investigate Information Flow Control (IFC) as a possible technical solution to expressing, enforcing and demonstrating compliance of cloud computing systems with policy requirements inspired by data protection and other laws. We focus on geographic location of data, since this is the paradigmatic concern of legal/regulatory requirements on cloud computing and, to date, has not been met with robust technical solutions and verifiable data flow audit trails.Engineering and Applied Science

Research data supporting "Adblocking and Counter-Blocking: A Slice of the Arms Race"

Data to accompany the paper Adblocking and Counter-Blocking: A Slice of the Arms Race.Javascript files from Alexa Top 5000 sites, and accompanying analysis code.EPSRC [EP/L003406/1