An overview of in-flight plume diagnostics for rocket engines

An overview and progress report of the work performed or sponsored by LeRC toward the development of in-flight plume spectroscopy technology for health and performance monitoring of liquid propellant rocket engines are presented. The primary objective of this effort is to develop technology that can be utilized on any flight engine. This technology will be validated by a hardware demonstration of a system capable of being retrofitted onto the Space Shuttle Main Engines for spectroscopic measurements during flight. The philosophy on system definition and status on the development of instrumentation, optics, and signal processing with respect to implementation on a flight engine are discussed

Materials Science

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67251/2/10.1177_00220345830620051601.pd

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Renal cell carcinoma(RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival

CCDC 113075: Experimental Crystal Structure Determination

Related Article: P.M.Narula, C.S.Day, B.A.Powers, M.A.Odian, A.Lachgar, W.T.Pennington, R.E.Noftle|1999|Polyhedron|18|1751|doi:10.1016/S0277-5387(99)00055-8,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 113074: Experimental Crystal Structure Determination

Related Article: P.M.Narula, C.S.Day, B.A.Powers, M.A.Odian, A.Lachgar, W.T.Pennington, R.E.Noftle|1999|Polyhedron|18|1751|doi:10.1016/S0277-5387(99)00055-8,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 113076: Experimental Crystal Structure Determination

Related Article: P.M.Narula, C.S.Day, B.A.Powers, M.A.Odian, A.Lachgar, W.T.Pennington, R.E.Noftle|1999|Polyhedron|18|1751|doi:10.1016/S0277-5387(99)00055-8,An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures