Doing Science: How to optimise patient and public involvement in your research

This paper considers how best to achieve patient and public involvement in research and how to get the most out of it http://ow.ly/R0hwV

Doing Science: How to optimise patient and public involvement in your research

This paper considers how best to achieve patient and public involvement in research and how to get the most out of it http://ow.ly/R0hw

Interacting Hofstadter spectrum of atoms in an artificial gauge field

Motivated by experimental advances in the synthesis of gauge potentials for ultracold atoms, we consider the superfluid phase of interacting bosons on a square lattice in the presence of a magnetic field. We show that superfluid order implies spatial symmetry breaking, and predict clear signatures of many-body effects in time-of-flight measurements. By developing a Bogoliubov expansion based on the exact Hofstadter spectrum, we find the dispersion of the quasiparticle modes within the superfluid phase, and describe the consequences for Bragg spectroscopy measurements. The theory also provides an estimate of the critical interaction strength at the transition to the Mott insulator phase.Comment: 4+ pages, 2 figures; v2: published versio

An assessment of scup (Stenotomus chrysops) and black sea bass (Centropristas striata) discards in the directed otter trawl fisheries in the Mid-Atlantic Bight

This study was undertaken to re-assess the level of scup (Stenotomus chrysops) discards by weight and to evaluate the effect of various codend mesh sizes on the level of scup discards in the winter-trawl scup fishery. Scup discards were high in directed scup tows regardless of codend mesh — typically one to five times the weight of landings. The weight of scup discards in the present study did not differ significantly from that recorded in scup-targeted tows in the NMFS observer database. Most discards were required as such by the 22.86 cm TL (total length) fish-size limit for catches. Mesh sizes ≤12.7 cm, including the current legal mesh size (11.43 cm) did not adequately filter out scup smaller than 22.86 cm. The median length of scup discards was about 19.83 cm TL. Lowering the legal size for scup from 22.86 to 19.83 cm TL would greatly reduce discard mortality. Scup discards were a small fraction (0.4%) of black sea bass (Centropristis striata) landings in blacksea-bass−targeted tows. The black sea bass fishery is currently regulated under the small-mesh fishery gearrestricted area plan in which fishing is prohibited in some areas to reduce scup mortality. Our study found no evidence to support the efficacy of this management approach. The expectations that discarding would increase disproportionately as the trip limit (limit [in kilograms] on catch for a species) was reached towards the end of the trip and that discards would increase when the trip limit was reduced from 4536 kg to 454 kg at the end of the directed fishing season were not supported. Trip limits did not significantly affect discard mortality

Tunable fishnet metamaterials infiltrated by liquid crystals

We analyze numerically the optical response and effective macroscopic parameters of fishnet metamaterials infiltrated with a nematic liquid crystal. We show that even a small amount of liquid crystal can provide tuning of the structures due to reorientation of the liquid crystal director. This enables switchable optical metamaterials, where the refractive index can be switched from positive to negative by an external field. This tuning is primarily determined by the shift of the cut-off wavelength of the holes, with only a small influence due to the change in plasmon dispersio

Scattering of electromagnetic waves in metamaterial superlattices

The authors study experimentally both transmission and reflection of microwave radiation from metamaterialsuperlattices created by layers of periodically arranged wires and split-ring resonators. The authors measure the dependence of the metamaterial resonance on the spatial period of the superlattice and demonstrate resonance broadening and splitting for the binary metamaterial structures.The authors acknowledge support from the Australian Research Council and thank Ekmel Ozbay for providing additional details of the experimental results published earlier by his group

The Conserved G-Protein Coupled Receptor FSHR-1 Regulates Protective Host Responses to Infection and Oxidative Stress

The innate immune system’s ability to sense an infection is critical so that it can rapidly respond if pathogenic microorganisms threaten the host, but otherwise maintain a quiescent baseline state to avoid causing damage to the host or to commensal microorganisms. One important mechanism for discriminating between pathogenic and non-pathogenic bacteria is the recognition of cellular damage caused by a pathogen during the course of infection. InCaenorhabditis elegans, the conserved G-protein coupled receptor FSHR-1 is an important constituent of the innate immune response. FSHR-1 activates the expression of antimicrobial infection response genes in infected worms and delays accumulation of the ingested pathogenPseudomonas aeruginosa. FSHR-1 is central not only to the worm’s survival of infection by multiple pathogens, but also to the worm’s survival of xenobiotic cadmium and oxidative stresses. Infected worms produce reactive oxygen species to fight off the pathogens; FSHR-1 is required at the site of infection for the expression of detoxifying genes that protect the host from collateral damage caused by this defense response. Finally, the FSHR-1 pathway is important for the ability of worms to discriminate pathogenic from benign bacteria and subsequently initiate an aversive learning program that promotes selective pathogen avoidance

Immunotherapy as a treatment strategy in advanced stage and recurrent endometrial cancer: Review of current phase III immunotherapy clinical trials

The treatment of advanced stage, metastatic or recurrent endometrial cancer remains a clinically difficult scenario. Although combination carboplatin and paclitaxel is an effective standard-of-care regimen, alternate strategies have shown promise, particularly in biomarker select populations. In an effort to improve oncologic outcomes, investigators are exploring novel immunotherapy combinations. In this review, we discuss the clinical rationale and design of current phase III immuno-oncology clinical trials in patients with advanced stage or recurrent endometrial cancer

Equal access for equal need: Eliciting public preferences for access to health treatment by employment status

The National Health Service in the UK is set up under the principle of “equal access for equal need”, where those with identical medical needs should be given equal priority in receiving health care. However, non-medical needs may also be relevant in health care decision-making. This paper considers how members of the general public value access to a health service given equal medical needs, where some service users have additional non-medical needs. There are three primary research questions. First, are public preferences regarding access to a health care service symmetric and inequality averse? Second, are public preferences asymmetric across different needs groups? And third, which individual characteristics of respondents are predictive of different public preferences in this domain? An online survey of the UK general public was conducted in January 2017 using binary choice questions. The hypothetical scenarios involved allocating extra resources from a social perspective, to reduce the waiting time to access a mental health service for the unemployed, for the employed, or for both groups. Based on a valid sample of 662 respondents, the study found that the three main preference categories were: inequality averse and symmetric, inequality averse and asymmetric in favour of the unemployed, and inequality seeking and asymmetric in favour of the unemployed, with the first group being the largest. Respondents’ current labour market status was found to explain their preferences so that those who were currently job-seeking were more likely to demonstrate preferences that favoured the unemployed, and those who were currently unemployed were less likely to demonstrate asymmetric preferences that favoured the employed. The implications from these findings are that health policies in the UK that support equal access for equal medical need are likely to be received most favourably, yet a non-trivial minority may support policies favouring those with other, non-medical needs

RH-RT: A Data Analytics Framework for Reducing Wait Time at Emergency Departments and Centres for Urgent Care

This is the author accepted manuscript. The final version is available from IEEE via the DOI in this recordRight Hospital – Right Time (RH-RT) is the conceptualization of the use of descriptive, predictive and prescriptive analytics with real-time data from Accident & Emergency (A&E)/Emergency Departments (ED) and centers for urgent care; its objective is to derive maximum value from wait time data by using data analytics techniques, and making them available to both patients and healthcare organizations. The paper presents an architecture for the implementation of RH-RT that is specific to the authors’ current work on a digital platform (NHSquicker) that makes available live waiting time from multiple centers of urgent care (e.g., A&E/ED, Minor Injury Units) in Devon and Cornwall. The focus of the paper is on the development of a Hybrid Systems Model (HSM) comprising of healthcare business intelligence, forecasting techniques and computer simulation. The contribution of the work is the conceptual RH-RT framework and its implementation architecture that relies on near real-time data from NHSquicker.Torbay Medical Research FundEconomic and Social Research Council (ESRC)Torbay Medical Research FundAcademic Health Science Networ