Spatial Delight and Environmental Performance of Modernist Architecture in London – Golden Lane Estate

This paper investigated the spatial delight and environmental performance of the open spaces and two selected apartments in the modernist buildings at Golden Lane Estate built after the 2nd World War, between 1952 and 1961. This estate is a Grade II listed, high density, low cost housing complex designed by three young architects: Peter Chamberlin, Geoffrey Powell and Christof Bon. It was built over a bombed site and well embraced the post-war modern architecture ethos, environmental considerations and inclusion of social facilities and landscaped communal spaces. Selected communal open spaces and two apartments in different building blocks with similar attributes were chosen for this study. However, one apartment has been refurbished with internal insulation and secondary glazing for improving the comfort conditions. Through fieldwork, which included subjective observation of the spatial quality of both outdoor and indoor spaces, on-site monitoring and interview of the building occupants, first-hand information on the environmental and comfort conditions inside the apartments were obtained. Through performance based theoretical analysis, archival research and observations, the spatial quality and comfort conditions in the apartments and their energy demand were critically assessed. The research findings indicate that the design of the communal outdoor spaces in the Golden Lane Estate were well thought through and the spacing between the building blocks responded well to the requirements of spatial delight, solar and daylight access and outdoor environmental comfort. Through selective enhancement of the thermal property of the building envelope, the original naturally ventilated and well day-lit living environments were maintained while energy demand was reduced by 30%, and the overall comfort level was significantly improved. This paper presents the feasible strategies to tackle the environmental challenges in the post-war Grade II listed residential buildings in the UK

The investigation of Spatial Delight and Environmental Performance of Modernist Architecture in London – Golden Lane Estate

This paper investigated the spatial delight and environmental performance of two selected apartments in the modernist buildings at Golden Lane Estate built after the 2nd World War. This estate is a Grade II listed, high density, low cost housing complex designed by three young architects: Peter Chamberlin, Geoffrey Powell and Christof Bon and it was built over a bombed site, and well embraced the post-war modern architecture ethos, environmental considerations and inclusion of social facilities and landscaped communal spaces. Two apartments in different building blocks with similar size, orientation, internal layout, use of materials and building elements were chosen for this study. However, one apartment has been refurbished with internal insulation and secondary glazing for improving the comfort conditions. Through fieldwork, which included on-site monitoring and interview of the building occupants, first-hand information on the environmental and comfort conditions inside the apartments were obtained. Through performance based theoretical analysis, the comfort conditions in the apartments and energy consumption were critically assessed. The research findings indicate that through selective enhancement of the thermal property of the building envelopes by internal insulation, introduction of secondary glazing over the original single glazed windows and the improvement on the air tightness in the apartments, the original naturally ventilated and well day-lit living environments were maintained while the overall comfort level was significantly improved. This paper presents the feasible strategies to deal with the environmental challenges in the post-war Grade II listed residential buildings in the UK

Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC:A Comparison Study

Simple Summary We compared the UltraSEEK (TM) Lung Panel on the MassARRAY (R) System (Agena Bioscience) with the FDA-approved Cobas (R) EGFR Mutation Test v2 for the detection of EGFR mutations in liquid biopsies of NSCLC patients, accompanied with preanalytical sample assessment using the novel Liquid IQ (R) Panel. For the detection of relevant predictive mutations using the UltraSEEK (TM) Lung Panel, an input of over 10 ng showed 100% concordance with Cobas (R) EGFR Mutation Test v2 and detection of all tissue confirmed mutations. In case of lower ccfDNA input, the risk of missing clinically relevant mutations should be considered. The use of a preanalytical ccfDNA quality control assay such as the Liquid IQ (R) Panel is recommended to confidently interpret results, avoiding bias induced by non-specific genomic DNA and low input of specific tumoral ccfDNA fragments. Plasma-based tumor mutational profiling is arising as a reliable approach to detect primary and therapy-induced resistance mutations required for accurate treatment decision making. Here, we compared the FDA-approved Cobas (R) EGFR Mutation Test v2 with the UltraSEEK (TM) Lung Panel on the MassARRAY (R) System on detection of EGFR mutations, accompanied with preanalytical sample assessment using the novel Liquid IQ (R) Panel. 137 cancer patient-derived cell-free plasma samples were analyzed with the Cobas (R) and UltraSEEK (TM) tests. Liquid IQ (R) analysis was initially validated (n = 84) and used to determine ccfDNA input for all samples. Subsequently, Liquid IQ (R) results were applied to harmonize ccfDNA input for the Cobas (R) and UltraSEEK (TM) tests for 63 NSCLC patients. The overall concordance between the Cobas (R) and UltraSEEK (TM) tests was 86%. The Cobas (R) test detected more EGFR exon19 deletions and L858R mutations, while the UltraSEEK (TM) test detected more T790M mutations. A 100% concordance in both the clinical (n = 137) and harmonized (n = 63) cohorts was observed when >10 ng of ccfDNA was used as determined by the Liquid IQ (R) Panel. The Cobas (R) and UltraSEEK (TM) tests showed similar sensitivity in EGFR mutation detection, particularly when ccfDNA input was sufficient. It is recommended to preanalytically determine the ccfDNA concentration accurately to ensure sufficient input for reliable interpretation and treatment decision making

Brachytherapy of stage II mobile tongue carcinoma. Prediction of local control and QOL

BACKGROUND: There is no consensus as to the prognostic model for brachytherapy of tongue carcinoma. This study was designed to evaluate the prognostic factors for local control based on a large population under a unified treatment policy. RESULTS: Between 1970 and 1998, 433 patients with stage II tongue squamous cell carcinoma were treated by low-dose-rate brachytherapy. This series included 277 patients treated with a linear source with a minimum follow-up of 3 years. A spacer was introduced in 1987. The primary local control rates were 85.6%. CONCLUSION: In the multivariate analysis, an invasive growth pattern was a significant factor for local recurrence. The disease-related survival was influenced by old age and an invasive growth pattern. A spacer lowered mandibular bone complications. The growth pattern was the most important factor for recurrence. Brachytherapy was associated with a high cure rate and the use of spacers brought about good quality of life (QOL)

Evaluation de l'inflammation synoviale par IRM, avant et après une injection intra-articulaire d'IL-1Ra (Anakinra) chez 7 patients souffrant de gonarthrose

Nous proposons d'évaluer: l'IL-1Ra ( anakinra ) dans la gonarthrose en étudiant l inflammation synoviale par IRM avant et après injection intra-articulaire chez 7 patients atteints de gonarthrose symptomatique. Ces 7 patients sont également évalués cliniquement par l'EVAet le WOMAC à JO, J1, J4, S4, S8 et S12. L'inflammation de la membrane synoviale est évaluée à l'aide d'un imageur de 1,5T avant injection et 36 heures après. Des séquences 3D-FGRE en coupes sagittales et axiales sont utilisées en pondération T1 avec saturation du signal de la graisse avant et après injection de gadolinium. L'évaluation de l'inflammation synoviale est tri-modale : score semi-quantitatif, volume total et volume de synovite active. L'épanchement est également gradé en 3 stades : faible, moyen et important sur des séquences pondérées T2. Les données pharmacocinétiques sont obtenues aux heures 0,1 2, 4, 8, 12, 24, 36 et 48 après injection d'anakinra, elles sont exprimées en concentrations maximales et en temps de résidence dans le compartiment plasmatique. Le score semi-quantitatif passe de 7,71 +- 1,38 à 6,71 +- 0,97 36 heures après l'injection d'anakinra. On n'observe pas de variation significative du volume total, du volume de synovite active et du score de l'épanchement. Ceci suggère un effet anti-inflammatoire de l'anakinra sur le score semi-quantitatif parallèlement à l'amélioration clinique constatée à J4.NANCY1-SCD Medecine (545472101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

La viscosupplémentation par Hylane GF-20 dans la coxarthrose (une étude ouverte à propos de 55 patients)

Objectif : Evaluer l'efficacité de la viscosupplémentation par HYLANE GF-20 chez des patients souffrant de coxarthrose et évaluer l'influence de la présence d'un épanchement articulaire sur la réponse au traitement. Patients et Méthode : 55 patients ont été inclus. Les paramètres suivants étaient évalués à 1 (M1), 3 (M3) et 6 mois (M6) : EVA douleur, indice algo-fonctionnel de Lequesne (IAFL), score de WOMAC, amélioration globale ressentie par le patient et 2 questionnaires de qualité de vie (SF 36 et AMIQUAL). La proportion de patients répondeurs selon les critères OARSI ou ayant atteint les valeurs du PASS a été analysée dans la population totale et selon la présence ou non d'un épanchement articulaire échographique initial. Résultats : La proportion de patients répondeurs selon les critères OARSI était à M1, M3 et M6 de 31,8%, 39,4% et 14,8%. La proportion de patients ayant atteint les valeurs du PASS douleur et fonction était respectivement à M1, 52,4% et 50%, à M3 67,7% et 54,5%, et à M6 60% et 50%. 24 patients (44%) présentaient un épanchement. La présence d'un épanchement n'a pas modifié la réponse au traitement. Conclusion : Nous avons montré un effet symptomatique modeste de la viscosupplémentation dans la coxarthrose avec une efficacité maximale à 3 mois, qui ne se maintient pas à 6 mois. La présence d'un épanchement articulaire n'influe pas sur la réponse au traitement.NANCY1-SCD Medecine (545472101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Etude volumique en IRM des synovites et des ténosynovites des poignets chez 25 patients atteints de polyarthrite rhumatoïde (rôle prédictif de l'évolution structurale à 1 an)

L'objectif est d'évaluer pour la première fois en IRM le volume de synovite et de ténosynovite aux poignets et sa vitesse de rehaussement dans la polyarthrite rhumatoïde (PR) et déterminer son caractère prédictif de l'évolution structurale radiographique à 1 an. Vingt-cinq patients ont une évaluation clinique, biologique et radiographique initiale et à 1 an. Le volume de synovite et de ténosynovite (VST) est calculé aux poignets sur 5 coupes successives IRM Tl-injectées. En fonction de la vitesse de rehaussement, 3 catégories de synovite sont définies : à rehaussement élevé (>=1% S- ), moyen (>=0,3% S- et <1% S- ) et faible (c0,3% S- ) et leurs volumes calculés. La progression structurale est définie par l'aggravation de plus de 5 points du score de Sharp mains à 1 an (SDD=4,9). Vingt-trois patients sur 25 (92%) ont des synovites, localisées le plus fréquemment au niveau intra-carpien. Les ténosynovites sont présentes chez 21 patients (84%). L'atteinte des tendons extenseurs est la plus fréquente (95,2%). Le VST médian est de 837,5 mm . L'évaluation volumique fait preuve d'une excellente reproductibilité inter et intra-lecteur (ICC=0,93-0,99 et ICC=0,75-0,95). En étude transversale, il n'y a aucune corrélation entre les différents volumes de synovite et de ténosynovite et les paramètres cliniques, biologiques et clinico-biologiques d'activité de la maladie. Seule la CRP est corrélée modérément à la progression structurale à 1 an (r=0,56; p=0,003), alors que le volume total et les volumes pour les différentes catégories de rehaussement ne le sont pas.NANCY1-SCD Medecine (545472101) / SudocNANCY1-Bib. numérique (543959902) / SudocSudocFranceF