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A genome-wide association study reveals specific transferases as candidate loci for bovine milk oligosaccharides synthesis.
BackgroundHuman milk oligosaccharides (OS) play a key role in brain and gut microbiota development of the neonate, but the underlying biosynthetic steps of OS in the mammary gland are still largely unknown. As bovine milk contains OS with somewhat similar structures and functionalities there is increased interest in further understanding the genetic basis underlying the OS content of milk for eventual extraction and generation of value-added ingredients for infant formulas and nutraceuticals. The present study is the first to report on genetic parameter estimation as well as on a genome wide association study (GWAS) from the largest bovine milk OS dataset analyzed to date.ResultsIn total 15 different bovine milk OS were monitored. Heritabilities ranged from 0 to 0.68 in Danish Holstein and from 0 to 0.92 in Danish Jersey. The GWAS identified in total 1770 SNPs (FDR < 0.10) for five different OS in Danish Holstein and 6913 SNPs (FDR < 0.10) for 11 OS in Danish Jersey. In Danish Holstein, a major overlapping QTL was identified on BTA1 for LNH and LNT explaining 24% of the variation in these OS. The most significant SNPs were associated with B3GNT5, a gene encoding a glycosyltransferase involved in glycan synthesis. In Danish Jersey, a very strong QTL was detected for the OS with composition 2 Hex 1 HexNAc (isomer 1) on BTA11. The most significant SNP had -log10(P-value) of 52.88 (BOVINEHD1100030300) and was assigned to ABO, a gene encoding ABO blood group glycosyltransferases. This SNP has been reported to be a missense mutation and explains 56% of the OS variation. Other candidate genes of interest identified for milk OS were ALG3, B3GALNT2, LOC520336, PIGV, MAN1C1, ST6GALNAC6, GLT6D1, GALNT14, GALNT17, COLGALT2, LFNG and SIGLEC.ConclusionTo our knowledge, this is the first study documenting a solid breeding potential for bovine milk OS and a strong indication of specific candidate genes related to OS synthesis underlying this genetic influence. This new information has the potential to guide breeding strategies to achieve production of milk with higher diversity and concentration of OS and ultimately facilitate large-scale extraction of bovine milk OS
Atomic quantum superposition state generation via optical probing
We analyze the performance of a protocol to prepare an atomic ensemble in a
superposition of two macroscopically distinguishable states. The protocol
relies on conditional measurements performed on a light field, which interacts
with the atoms inside an optical cavity prior to detection, and we investigate
cavity enhanced probing with continuous beams of both coherent and squeezed
light. The stochastic master equations used in the analysis are expressed in
terms of the Hamiltonian of the probed system and the interaction between the
probed system and the probe field and are thus quite generally applicable.Comment: 10 pages, 9 figure
Manipulating the torsion of molecules by strong laser pulses
A proof-of-principle experiment is reported, where torsional motion of a
molecule, consisting of a pair of phenyl rings, is induced by strong laser
pulses. A nanosecond laser pulse spatially aligns the carbon-carbon bond axis,
connecting the two phenyl rings, allowing a perpendicularly polarized, intense
femtosecond pulse to initiate torsional motion accompanied by an overall
rotation about the fixed axis. The induced motion is monitored by femtosecond
time-resolved Coulomb explosion imaging. Our theoretical analysis accounts for
and generalizes the experimental findings.Comment: 4 pages, 4 figures, submitted to PRL; Major revision of the
presentation of the material; Correction of ion labels in Fig. 2(a
Differential atom interferometry beyond the standard quantum limit
We analyze methods to go beyond the standard quantum limit for a class of
atomic interferometers, where the quantity of interest is the difference of
phase shifts obtained by two independent atomic ensembles. An example is given
by an atomic Sagnac interferometer, where for two ensembles propagating in
opposite directions in the interferometer this phase difference encodes the
angular velocity of the experimental setup. We discuss methods of squeezing
separately or jointly observables of the two atomic ensembles, and compare in
detail advantages and drawbacks of such schemes. In particular we show that the
method of joint squeezing may improve the variance by up to a factor of 2. We
take into account fluctuations of the number of atoms in both the preparation
and the measurement stage, and obtain bounds on the difference of the numbers
of atoms in the two ensembles, as well as on the detection efficiency, which
have to be fulfilled in order to surpass the standard quantum limit. Under
realistic conditions, the performance of both schemes can be improved
significantly by reading out the phase difference via a quantum non-demolition
(QND) measurement. Finally, we discuss a scheme using macroscopically entangled
ensembles.Comment: 10 pages, 5 figures; eq. (3) corrected and other minor change
Entanglement-enhanced quantum rectification
Quantum mechanics dictates the band-structure of materials that is essential
for functional electronic components. With increased miniaturization of devices
it becomes possible to exploit the full potential of quantum mechanics through
the principles of superpositions and entanglement. We propose a new class of
quantum rectifiers that can leverage entanglement to dramatically increase
performance by coupling two small spin chains through an effective double-slit
interface. Simulations show that rectification is enhanced by several orders of
magnitude even in small systems and should be realizable using several of the
quantum technology platforms currently available.Comment: 5+15 pages, 3+6 figure
Semi-Static Hedging Based on a Generalized Reflection Principle on a Multi Dimensional Brownian Motion
On a multi-assets Black-Scholes economy, we introduce a class of barrier
options. In this model we apply a generalized reflection principle in a context
of the finite reflection group acting on a Euclidean space to give a valuation
formula and the semi-static hedge.Comment: Asia-Pacific Financial Markets, online firs
Investing in Prevention or Paying for Recovery - Attitudes to Cyber Risk
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Broadly speaking an individual can invest time and effort to avoid becoming victim to a cyber attack and/or they can invest resource in recovering from any attack. We introduce a new game called the pre-vention and recovery game to study this trade-off. We report results from the experimental lab that allow us to categorize different approaches to risk taking. We show that many individuals appear relatively risk loving in that they invest in recovery rather than prevention. We find little difference in behavior between a gain and loss framing
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