SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS : III. ASSEMBLY OF THE THREE SUBCLASSES OF IGG

The synthesis, assembly, and secretion of the three major subclasses of mouse IgG has been examined in 14 myeloma tumors and two cultured cell lines as well as in the cells from the popliteal lymph nodes of immunized mice. The total amount of IgG synthesized was between 15 and 43% of the cytoplasmic proteins made during a 15 min period. H2 and H2L were the major precursors of IgG2a and IgG1 but, in all of the tumors, HL was also an intermediate. In contrast, HL was a major precursor of IgG2b. Most of the noncovalent and covalent assembly of IgG occurred after release of the newly synthesized H and L chains from the polyribosomes and assembly was not completed until 10 min or more after the synthesis of the polypeptide chains

Thermodynamics of ideal quantum gas with fractional statistics in D dimensions

We present exact and explicit results for the thermodynamic properties (isochores, isotherms, isobars, response functions, velocity of sound) of a quantum gas in dimensions D>=1 and with fractional exclusion statistics 0<=g<=1 connecting bosons (g=0) and fermions (g=1). In D=1 the results are equivalent to those of the Calogero-Sutherland model. Emphasis is given to the crossover between boson-like and fermion-like features, caused by aspects of the statistical interaction that mimic long-range attraction and short-range repulsion. The full isochoric heat capacity and the leading low-T term of the isobaric expansivity in D=2 are independent of g. The onset of Bose-Einstein condensation along the isobar occurs at a nonzero transition temperature in all dimensions. The T-dependence of the velocity of sound is in simple relation to isochores and isobars. The effects of soft container walls are accounted for rigorously for the case of a pure power-law potential.Comment: 15 pages, 31 figure

Discovery of a High Proper Motion L Dwarf Binary: 2MASS J15200224-4422419AB

We report the discovery of the wide L1.5+L4.5 binary 2MASS J15200224-4422419AB, identified during spectroscopic followup of high proper motion sources selected from the Two Micron All Sky Survey. This source was independently identified by Kendall et al. in the SuperCOSMOS Sky Survey. Resolved JHK photometry and low resolution near-infrared spectroscopy demonstrate that this system is composed of two well-separated (1"174+/-0"016) L dwarfs. Component classifications are derived using both spectral ratios and comparison to near-infrared spectra of previously classified field L dwarfs. Physical association for the pair is deduced from the large (mu = 0"73+/-0"03 /yr) common proper motion of the components and their similar spectrophotometric distances (19+/-2 pc). The projected separation of the binary, 22+/-2 AU, is consistent with maximum separation/total system mass trends for very low mass binaries. The 2MASS J1520-4422 system exhibits both large tangential (66+/-7 km/s) and radial velocities (-70+/-18 km/s), and its motion in the local standard of rest suggests that it is an old member of the Galactic disk population. This system joins a growing list of well-separated (>0"5), very low mass binaries, and is an excellent target for resolved optical spectroscopy to constrain its age as well as trace activity/rotation trends near the hydrogen-burning limit.Comment: 35 pages, 8 figures; accepted for publication to ApJ; see also Kendall et al. astro-ph/060939

Pseudo-ductility in intermingled carbon/glass hybrid composites with highly aligned discontinuous fibres

AbstractThe aim of this research is to manufacture intermingled hybrid composites using aligned discontinuous fibres to achieve pseudo-ductility. Hybrid composites, made with different types of fibres that provide a balanced suite of modulus, strength and ductility, allow avoiding catastrophic failure that is a key limitation of composites. Two different material combinations of high strength carbon/E-glass and high modulus carbon/E-glass were selected. Several highly aligned and well dispersed short fibre hybrid composites with different carbon/glass ratios were manufactured and tested in tension in order to investigate the carbon ratio effect on the stress–strain curve. Good pseudo-ductile responses were obtained from the high modulus carbon/E-glass composites due to the fragmentation of the carbon fibres. The experimental results were also compared with an analytical solution. The intermingled hybrid composite with 0.25 relative carbon ratio gave the maximum pseudo-ductile strain, 1.1%, with a 110GPa tensile modulus. Moreover, the initial modulus of the intermingled hybrids with 0.4 relative carbon ratio is 134GPa, 3.5 times higher than that of E-glass/epoxy composites. The stress–strain curve shows a clear “yield point” at 441MPa and a well dispersed and gradual damage process

The seroprevalence and factors associated with Ross River virus infection in Western Grey Kangaroos (Macropus fuliginosus) in Western Australia

A serosurvey was undertaken in 15 locations in the midwest to southwest of Western Australia (WA) to investigate the seroprevalence of Ross River virus (RRV) neutralizing antibodies and factors associated with infection in western grey kangaroos (Macropus fuliginosus). The estimated seroprevalence in 2632 kangaroo samples, using a serum neutralization test, was 43.9% (95% CI 42.0, 45.8). Location was significantly associated with seroprevalence (p 0.05). The results of this study indicate that kangaroos in WA are regularly infected with RRV and may be involved in the maintenance and transmission of RRV

Fear, populism, and the geopolitical landscape: the “sleeper effect” of neurotic personality traits on regional voting behavior in the 2016 Brexit and Trump elections

Two recent electoral results - Donald Trump’s election as US president and the UK’s Brexit vote - have re-ignited debate on the psychological factors underlying voting behavior. Both campaigns promoted themes of fear, lost pride, and loss aversion, which are relevant to the personality dimension of Neuroticism, a construct previously not associated with voting behavior. To that end, we investigate whether regional prevalence of neurotic personality traits (Neuroticism, Anxiety, Depression) predicted voting behavior in the US (N = 3,167,041) and the UK (N = 417,217), comparing these effects with previous models, which have emphasized the roles of Openness and Conscientiousness. Neurotic traits positively predicted share of Brexit and Trump votes and Trump gains from Romney. Many of these effects persisted in additional robustness tests controlling for regional industrial heritage, political attitude, and socio-economic features, particularly in the US. The “sleeper effect” of neurotic traits may profoundly impact the geopolitical landscape