Health care professionals dealing with hemophilia: Insights from the international qualitative study of the HERO initiative

Background: Assessing the viewpoints of health care professionals concerning their work with chronic patients is a relatively new research topic, widely overlooked in the literature. However, understanding their subjective work experience is highly relevant for identifying problems and perceived resources, enhancing health service organisation, improving relationships or communication with patients, and maintaining well-being. Purpose and method: Qualitative data from the \u201cHaemophilia Experience, Results and Opportunities\u201d Initiative \u2013 a research program aimed at investigating the psychosocial aspects of hemophilia \u2013 were used to evaluate the experiences of 62 professionals from seven countries around the world. Semi-structured interviews were submitted to thematic analysis of elementary contexts with the aid of T-Lab software. Results: Five dominant themes emerged, identifying the main challenges that professionals have to deal with in their everyday work practice: caring for impaired adult patients; handling policies and stakeholders; providing counselling on diagnosis and reproductive choices; considering the role of family dynamics; coping with adolescent patients. Conclusion: The outcomes of the study provide an opportunity to develop the area of the non-technical skills in the core curriculum of those who work with chronic illnesses by focusing on cross-professional competences and by improving a comprehensive care model for hemophilia patients

Optical Systems Identification through Rayleigh Backscattering

: We introduce a technique to generate and read the digital signature of the networks, channels, and optical devices that possess the fiber-optic pigtails to enhance physical layer security (PLS). Attributing a signature to the networks or devices eases the identification and authentication of networks and systems thus reducing their vulnerability to physical and digital attacks. The signatures are generated using an optical physical unclonable function (OPUF). Considering that OPUFs are established as the most potent anti-counterfeiting tool, the created signatures are robust against malicious attacks such as tampering and cyber attacks. We investigate Rayleigh backscattering signal (RBS) as a strong OPUF to generate reliable signatures. Contrary to other OPUFs that must be fabricated, the RBS-based OPUF is an inherent feature of fibers and can be easily obtained using optical frequency domain reflectometry (OFDR). We evaluate the security of the generated signatures in terms of their robustness against prediction and cloning. We demonstrate the robustness of signatures against digital and physical attacks confirming the unpredictability and unclonability features of the generated signatures. We explore signature cyber security by considering the random structure of the produced signatures. To demonstrate signature reproducibility through repeated measurements, we simulate the signature of a system by adding a random Gaussian white noise to the signal. This model is proposed to address services including security, authentication, identification, and monitoring

Secure quantum communication technologies and systems: From labs to markets

We provide a broad overview of current quantum communication by analyzing the recent discoveries on the topic and by identifying the potential bottlenecks requiring further investigation. The analysis follows an industrial perspective, first identifying the state or the art in terms of protocols, systems, and devices for quantum communication. Next, we classify the applicative fields where short- and medium-term impact is expected by emphasizing the potential and challenges of different approaches. The direction and the methodology with which the scientific community is proceeding are discussed. Finally, with reference to the European guidelines within the Quantum Flagship initiative, we suggest a roadmap to match the effort community-wise, with the objective of maximizing the impact that quantum communication may have on our society

Probabilistic Amplitude Shaping for Continuous-Variable Quantum Key Distribution with Discrete Modulation over a Wiretap Channel

To achieve the maximum information transfer and face a possible eavesdropper, the samples transmitted in continuous-variable quantum key distribution (CV-QKD) protocols are to be drawn from a continuous Gaussian distribution. As a matter of fact, in practical implementations the transmitter has a finite (power) dynamics and the Gaussian sampling can be only approximated. This requires the quantum protocols to operate at small powers. In this paper, we show that a suitable probabilistic amplitude shaping of a finite set of symbols allows to approximate at will the optimal channel capacity also for increasing average powers. We investigate the feasibility of this approach in the framework of CV-QKD, propose a protocol employing discrete quadrature amplitude modulation assisted with probabilistic amplitude shaping, and we perform the key generation rate analysis assuming a wiretap channel and lossless homodyne detection

Associations of Alcoholic Beverage Consumption with Dietary Intake, Waist Circumference, and Body Mass Index in US Adults: National Health and Nutrition Examination Survey 2003-2012

Background: Findings from studies of alcohol and obesity measures (eg, waist circumference [WC] and body mass index [BMI; calculated as kg/m 2 ]) are conflicting. Residual confounding by dietary intake, inconsistent definitions of alcohol consumption across studies, and the inclusion of former drinkers in the nondrinking comparison group can contribute to the mixed literature. Objective: This study examines associations of alcoholic beverage consumption with dietary intake, WC, and BMI. Design: Cross-sectional data from the 2003-2012 National Health and Nutrition Examination Survey were analyzed. Participants/setting: Adults 20 to 79 years of age (n=7,436 men; n=6,939 women) were studied. Main outcome measures: Associations of alcoholic beverage consumption with energy (kcal), macronutrient and sugar intakes (% kcal), WC, and BMI were determined. Statistical analyses performed: Multivariable linear regression models were used to determine associations of average daily volume and drinking quantity (ie, drinks per drinking day) with dietary intake and obesity measures. Former and never drinkers were analyzed as distinct categories; associations of drinking with WC and BMI were examined with and without adjustment for dietary intake variables. Results: Heavier-drinking men (≥3 drinks/day) and women (≥2 drinks/day) consumed less nonalcoholic energy (β −252 kcal/day, 95% CI −346 to −159 kcal/day and β −159 kcal/day, 95% CI −245 to −73 kcal/day, respectively) than moderate drinkers (1 to 2 drinks/day in men and 1 drink/day in women). By average daily drinking volume, differences in WC and BMI between former and moderate drinkers were +1.78 cm (95% CI 0.51 to 3.05 cm) and +0.65 (95% CI 0.12 to 1.18) in men and +4.67 cm (95% CI 2.95 to 6.39 cm) and +2.49 (95% CI 1.64 to 3.34) in women. Compared with moderate drinking, heavier drinking volume was not associated with WC or BMI among men or women. In men, drinking ≥5 drinks/drinking day was associated with higher WC (β 3.48 cm, 95% CI 1.97 to 5.00 cm) and BMI (β 1.39, 95% CI 0.79 to 2.00) compared with men who consumed 1 to 2 drinks/drinking day. In women, WC and BMI were not significantly different for women drinking ≥4 drinks/drinking day compared with 1 drink/drinking day. Conclusions: Differences in dietary intake across drinking subgroups and separation of former drinkers from nondrinkers should be considered in studies of alcohol intake in relation to WC and BMI

Color-Coded Front-of-Pack Nutrition Labels—An Option for US Packaged Foods?

The implementation of a standardized front-of-pack-labelling (FoPL) scheme would likely be a useful tool for many consumers trying to improve the healthfulness of their diets. Our objective was to examine what the traffic light labelling scheme would look like if implemented in the US. Data were extracted from Label Insight’s Open Access branded food database in 2017. Nutrient levels and the proportion of products classified as “Red” (High), “Amber” (Medium) or “Green” (Low) in total fat, saturated fat, total sugar and sodium for food and beverage items were examined. The proportion of products in each category that had each possible combination of traffic light colors, and met the aggregate score for “healthy” was examined. Out of 175,198 products, >50% of all US packaged foods received a “Red” rating for total sugar and sodium. “Confectionery” had the highest mean total sugar (51.9 g/100 g) and “Meat and meat alternatives” the highest mean sodium (781 mg/100 g). The most common traffic light label combination was “Red” for total fat, saturated fat and sodium and “Green” for sugar. Only 30.1% of products were considered “healthy”. A wide variety (n = 80) of traffic light color combinations were observed. A color coded traffic light scheme appears to be an option for implementation across the US packaged food supply to support consumers in making healthier food choices

The “hitchhiker’s guide to the galaxy” of endothelial dysfunction markers in human fertility

Endothelial dysfunction is an early event in the pathogenesis of atherosclerosis and represents the first step in the pathogenesis of cardiovascular diseases. The evaluation of endothelial health is fundamental in clinical practice and several direct and indirect markers have been suggested so far to identify any alterations in endothelial homeostasis. Alongside the known endothelial role on vascular health, several pieces of evidence have demonstrated that proper endothelial functioning plays a key role in human fertility and reproduction. Therefore, this stateof‐the‐art review updates the endothelial health markers discriminating between those available for clinical practice or for research purposes and their application in human fertility. Moreover, new molecules potentially helpful to clarify the link between endothelial and reproductive health are evaluated herein

a compact silicon coherent receiver without waveguide crossing

A monolithically integrated silicon coherent receiver based on a novel scheme with a crossing-free 90 $^{\circ}$ hybrid optical coupler and two balanced germanium photodetectors is reported. The integrated receiver is compact (footprint is $0.8\times 1.0\ \hbox{mm}^{2}$ ), and it is demonstrated by working with single-polarization 56-Gb/s quadrature phase-shift keying (QPSK) and 80-Gb/s 16-quadrature amplitude modulation (16-QAM) signals. In particular, QPSK transmission that is back-to-back at 28 Gbaud shows a bit-error rate (BER) below $10^{-4}$ for an optical signal-to-noise ratio (OSNR) lower than 17 dB, whereas 16-QAM at 20 Gbaud shows a BER not better than $3^{\ast}10^{-2}$ because of the nonideal behavior of the device. Reasons for the performance limitations are discussed

Candidate paths for impairment-aware PCE in 10-100 Gb/s optical networks

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