5 research outputs found
Dementia in Latin America : paving the way towards a regional action plan
Regional challenges faced by Latin American and Caribbean countries (LACs) to fight dementia, such as heterogeneity, diversity, political instabilities, and socioeconomic disparities, can be addressed more effectively grounded in a collaborative setting based on the open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking and translational research) and align them to current global strategies to translate regional knowledge into actions with transformative power. Then, by characterizing genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions and mapping these to the above challenges, we provide the basic mosaics of knowledge that will pave the way towards a KtAF. We describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF
Evolving Classifiers to Inform Clinical Assessment of Parkinsonâs Disease
AbstractâWe describe the use of a genetic programming system to induce classifiers that can discriminate between Parkinsonâs disease patients and healthy age-matched controls. The best evolved classifer achieved an AUC of 0.92, which is comparable with clinical diagnosis rates. Compared to previous studies of this nature, we used a relatively large sample of 49 PD patients and 41 controls, allowing us to better capture the wide diversity seen within the Parkinsonâs population. Classifiers were induced from recordings of these subjects â movements as they carried out repetitive finger tapping, a standard clinical assessment for Parkinsonâs disease. For ease of interpretability, we used a relatively simple window-based classifier architecture which captures patterns that occur over a single tap cycle. Analysis of window matches suggested the importance of peak closing deceleration as a basis for classification. This was supported by a follow-up analysis of the data set, showing that closing deceleration is more discriminative than features typically used in clinical assessment of finger tapping. I
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Care ecosystem training: Developing a free online dementia course for a growing lay health workforce
Recommended from our members
Care ecosystem training: Developing a free online dementia course for a growing lay health workforce
Recommended from our members
Dementia in Latin America: Paving the way toward a regional action plan.
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF