A36 The TP53 mutations in the Russian patients with de novo DLBCL

BackgroundTP53 dysfunction is implicated in lymphomagenesis and disease progression. Information about the frequency and spectrum of TP53 mutations in the Russian pathients with diffuse large B-cell lymphoma (DLBCL) in the current version of the IARC TP53 Mutation Database R17 is not represented. The goal of this work was to study the frequency, spectrum and functional significance of TP53 mutations in Russian patients with DLBCL.Material and methodsAt the present time the pilot group of 14 patients were included in the study. Diagnosis was assessed according to the criteria of the WHO classification system. Genomic DNA was isolated from formalin-fixed, paraffin embedded tissue blocks. Direct sequence analysis of gene TP53 was performed according to the IARC protocol, 2010 update.ResultsIn two patients were identified single nucleotide substitutions that are not described in the current version of the PubMed database. All of mutations occurred in the DNA-binding domain of p53. The nonsense mutation Arg196Ter was detected in one patient. Previously it was shown that formation of this premature stop codon might activate the nonsense-mediated RNA decay pathway. The second patient had two missense mutations – Leu130Phe and Arg156Cys. The first of them leads to p53 inactivation according to the analysis of the functional importance of amino acid substitutions using service PolyPhen-2.ConclusionWe detected TP53 mutation in 14% cases. The mutational rate in our study is in good agreement with other studies where the frequency of the TP53 mutations in patients with DLBCL ranged mostly from 13% to 23%

FUTURE INNOVATION TRENDS IN LATIN AMERICA

This article off ers an analysis of innovation activities in three Latin American countries. Such components as the role of science, business communities, and public policies in the transition to a knowledge-based economy are analyzed. Based on the Gibbons Model, innovative models that are being implemented inBrazil,Chile, andMexicoare compared. The data obtained may be used as a practical tool in developing countries

New possibilities of the functionalization of 6-hydrazino-1,3-dimethyluracils: one-pot synthesis of 5,7-dimethylpyrazolopyrimidine-4,6-dione and 1,3-dimethyl-5-arylidenebarbituric acid derivatives

3-aryl-5,7-dimethylpyrazolopyrimidine-4,6-diones and 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-triones were obtained by heating hydrazones of 1,3-dimethyl-6 -hydrazinouraciles in trifluoroacetic acid (TFA). The same compounds were also obtained by heating the hydrazones of 1,3-dimethyl-6-hydrazinouraciles in aqueous ethanol in the presence of hydrochloric acid.3-aryl-5,7-dimethylpyrazolopyrimidine-4,6-diones and 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-triones were obtained by heating hydrazones of 1,3-dimethyl-6 -hydrazinouraciles in trifluoroacetic acid (TFA). The same compounds were also obtained by heating the hydrazones of 1,3-dimethyl-6-hydrazinouraciles in aqueous ethanol in the presence of hydrochloric acid

КОНЦЕПТУАЛЬНЫЕ ОСНОВЫ НЕОБХОДИМОСТИ ФОРМИРОВАНИЯ ТРОЙНОЙ СПИРАЛИ КАК ИННОВАЦИОННОЙ ВЕРШИНЫ ЭФФЕКТИВНОЙ НАЦИОНАЛЬНОЙ ЭКОНОМИКИ

The establishment of cooperation between the science, the state and business communities fosters the development and implementation of joint projects in various economic activity areas. The Triple Helix theory comprises the main participants forming research and technology clusters. In its turn, the development of clusters leads to the increase in economic activity of various regions of the countries where the Triple Helix is applied. Thus, the Triple Helix theory includes a whole system of players from various activity areas, with a relationship network established between them contributing to the formation of the efficient national economy. Формирование творческого сотрудничества между наукой, государством и бизнесом способствует развитию и функционированию совместных проектов в различных социально-экономических сферах. Теория «Тройной спирали» вбирает в себя научное обоснование участия всех главных сторон в формировании и функционировании научно-технологических кластеров. В свою очередь, создание кластеров ведет к увеличению экономической активности различных регионов страны, где реализуются научные принципы «Тройной спирали», так как теория «Тройной спирали» – это приведение в эффективную систему роли всех участников реализации различных инвестиционных проектов с приведением их взаимоотношений в экономически рациональное русло, обусловливающее формирование эффективной национальной экономики государства.

Features of -C-C- coupling of quinoxaline-2-one with ethyl acetoacetate under acid catalysis

Quinoxalin-2-one (1) reacts with ethyl acetoacetate in trifluoroacetic acid (TFA) to form 3-(2-oxopropylideno)-3,4-dihydroquinoxaline-2-one (2) and 3-(3-oxo-3,4- dihydroquinoxaline-2-(1H)-ylidene)methylquinoxaline-2-(1H)-one (3). The reaction product 3 was also obtained by heating the compound 1 with acetone in the presence of TFA

ДИНАМИКА ИННОВАЦИЙ В ЛАТИНСКОЙ АМЕРИКИ

This article off ers an analysis of innovation activities in three Latin American countries. Such components as the role of science, business communities, and public policies in the transition to a knowledge-based economy are analyzed. Based on the Gibbons Model, innovative models that are being implemented inBrazil,Chile, andMexicoare compared. The data obtained may be used as a practical tool in developing countries.Данная статья посвящена анализу инновационной активности ряда стран Латинской Америки. Проанализированы такие составляющие, как роль науки, бизнес-сообществ, а также государственная политика, направленная на переход к экономике, основанной на научных знаниях. На основании «the Gibbon’s Model» проведено сравнение инновационных моделей, которые реализуются в Бразилии, Чили и Мексике. Полученные данные можно использовать как практический инструментарий формирования инновационной политики в развивающихся странах. В заключение представлена оценка инновационной активности стран Латинской Америки

СОВРЕМЕННЫЕ ЗАДАЧИ ДИСЦИПЛИНЫ «ЭКОЛОГИЯ ЭНЕРГЕТИКИ» ПРИ ПОДГОТОВКЕ ИНЖЕНЕРА-ЭНЕРГЕТИКА, ПУТИ ИХ РЕШЕНИЯ

The paper presents a viewpoint to improvement and modernization of a taught course “Ecology of Power Engineering” in respect of its content, teaching forms and methods with the purpose to meet modern challenges of power engineering and sustainable development. Concrete recommendations for delivering lectures and practical classes are given in the paper with due account of requirements of practical designing and operation of power objects.Представлен взгляд на совершенствование и модернизацию дисциплины «Экология энергетики» в части содержания, форм и методов преподавания в ответ на современные вызовы энергетики и устойчивого развития. Даны конкретные предложения построения лекционного курса и практических занятий с учетом требований практики проектирования и эксплуатации энергетических объектов

Gradients of Taxonomic Diversity among Local Floras in the Russian Arctic

Latitudinal and longitudinal changes in taxonomic variables were analyzed in 319 local floras in the Russian Arctic. Within the studied segment of latitudinal gradient, most changes can be described in terms of linear regression with negative coefficients (a number of species, genera and families), or positive coefficients (a proportion of the leading families and genera). However, the mean number of species in a family or genus almost does not change with increasing latitude, although it slightly increases as one moves eastward. The proportion of monocots does not correlate with latitude, but slightly decreases as one moves eastward. Proportions of various families change asynchronously. Although correlation with longitude was less pronounced, mean species richness was specific to many subprovinces, even within a certain subzone. These differences reflect both the diversity of landscapes and the history of flora formation. Keywords: the Arctic, local floras, latitudinal and longitudinal gradient, floristic subprovince

Трансформация инновационных процессов и социокультурной специфики Южной Кореи в рамках четвертой индустриальной революции

Purpose: the main purpose of this article is to explore the specific characteristics of the innovation development of South Korea. To achieve this goal the following tasks must be solved in the article: research the main principles and steps in the development of South Korea; identify and analyze the successful factors of the South Korean «economic miracle» that will continue contributing to the development and growth of the country; describe the cultural and organizational factors limiting the speed of transformation of South Korea under the fourth industrial revolution.Methods: the main methods of the research are system, structural and qualitative analyses. For the study, statistical data and articles in Russian and foreign scientific and analytical publications were used. The article is contributed with the empirical findings from the case study conducted during direct involvement of the authors in one of the industrial companies of South Korea.Results: an in-depth analyses of the transformation periods during the innovation development of South Korea was carried out, which made it possible to formulate the conclusion about existing barriers originated in the organisational approaches used to achieve the former industrial success. The problems constraining the new paradigm shift are analyzed.Conclusions and Relevance: the materials stated in the article show that in modern conditions, transition of South Korea towards Industry 4.0 is constrained by several unique factors, that used to be the key success elements in the former stages of the innovation development of the country. The research conducted in this article represents the value to the activities of various organizations interested in the innovation development, especially for development of innovation policies from the aspect of the importance of oranisational and cultural behavior at a national level. Practical application of the suggested conclusions allows hierarchical and monocultural organisations to transition to the Industry 4.0 with the consideration of important economic and social dynamics. Цель: Основная цель статьи состоит в исследовании особенностей инновационного развития Южной Кореи. Для достижения поставленной цели авторами были исследованы основные принципы и этапы инновационного развития государства, выявлены и проанализированы сильные стороны, способствовавшие «экономическому чуду» Южной Кореи, а также поднят вопрос культурных и организационных барьеров, сдерживающих темп трансформации экономики в рамках четвертой индустриальной революции.Методология проведения работы: В представленной статье использована совокупность методов системного, структурного и качественного анализа. Представленное исследование проведено на основе изучения и обобщения теоретического материала и практического опыта, накопленного в ходе многолетней работы одного из авторов исследования в корейской корпорации. Для проведения исследования использовались статистические данные, статьи в российских и иностранных изданиях, а также результаты эмпирического анализа.Результаты работы: Проведен анализ характерных особенностей динамики инновационного развития Южной Кореи, что позволило сформулировать тезис о существующих пережитках, тормозящих прогресс в рамках новой парадигмы. Проанализированы проблемы, сдерживающие трансформацию промышленной экономики Южной Кореи.Выводы: Материалы, приведенные в статье, показывают, что в современных условиях переход Южной Кореи к четвертой индустриальной революции осложнен спецификой факторов, обусловивших успех инновационного прогресса в предыдущие периоды. Результаты исследования, изложенные в статье, важны для изучения шагов, необходимых для трансформации бизнес-процессов и корпоративной культуры в целях дальнейшего инновационного развития, а также учета социокультурной специфики страны при разработке инновационной политики. Изученный опыт возможно использовать при формировании экономики, основанной на знаниях, и в России. Практическое применение метода открытых инноваций позволяет совершенствовать переход в эпоху четвертой индустриальной революции применительно к иерархичным монокультурным структурам с учетом актуальных экономических и социальных тенденций.

COMPLEX ESTIMATION OF BRONCHOPULMONARY SYSTEM IN PATIENTS WITH HODGKINS LYMPHOMA

One of the important problems with patients with Hodgkin's lymphoma is lung injury, caused both by a tumor effect and the influence of chemoradiotherapy. Before the treatment an obstructive lung function pattern connected with tumor substrate has been revealed in 38% of cases. After chemoradiotherapy the restrictive lung pattern was shown in 14% of the patients and mixed lung pattern was seen in 12% of the cases, which were caused by the development of pneumosclerosis and emphysema