Diffraction of inelastically scattered electrons in tungsten at low energies

Diffraction of inelastically scattered electrons in tungsten at low energie

History and Future of Phosphate Mining and Beneficiation in South Africa

The major igneous phosphate deposit in Phalaborwa was discovered in 1904. The establishment of the Phosphate Development Corporation (Foskor) in 1951 catalyzed the development and growth of phosphate mining and phosphate fertilizer manufacturing in South Africa as well as associated businesses. This keynote address covers four major topics: 1) chemical and mineralogical properties of major phosphate deposits in South Africa, 2) mining and beneficiation practices, 3) technical challenges and evolution of processing technologies, and 4) future trends

The Development of the Poetry Walking Tour of Niagara Falls Using Mobile App Technology

The Niagara Falls Poetry Project (NFPP) has been an ongoing research-creation project for many years. In addition to being a site of poetry of place it is also a site of recovery and discovery of Niagara poetry. This MRP used social construction of technology and of literature theories as a framework to develop the Poetry Walking Tour of Niagara Falls (PWT) to extend the NFPP. Twenty-four points of interest were selected following a route along the Niagara River, passing Niagara Falls. Content analyses and close readings of the poetry on the NFPP website were conducted to preselect suitable poems to present to a panel of poets, academics, and end users at a Poetry Selection Event. Using the participatory design techniques of crowdsourcing and a modified Delphi method, the "best" poem for each of the points of interest was selected. The poem, explanatory historical and literary material, images, and multimedia were added to the Interpretours platform website, which was then used to populate the GuideTags mobile app for smartphones and tablets. The end result is a fully functional mobile app GPS guided walking tour of Niagara Falls that alerts users to points of interest that highlight the poetry and history of Niagara Falls. The role of the PWT in the local economy as a tourist attraction, particularly for the heritage and literary tourism sectors are contributions of the projec

Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks

Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly used in mammalian somatic cell genetics or to cure genetic diseases. Recently, it has been demonstrated that infection with recombinant adeno-associated virus (rAAV) vectors can mediate gene targeting in somatic cells, but the mechanism is unclear. This paper explores the balance between random integration and gene targeting with rAAV. Both random integration and spontaneous gene targeting are dependent on the multiplicity of infection (MOI) of rAAV. It has previously been shown that the introduction of a DNA double-stranded break (DSB) in a target gene can stimulate gene targeting by several-thousand-fold in somatic cells. Creation of a DSB stimulates the frequency of rAAV-mediated gene targeting by over 100-fold, suggesting that the mechanism of rAAV-mediated gene targeting involves, at least in part, the repair of DSBs by homologous recombination. Absolute gene targeting frequencies reach 0.8% with a dual vector system in which one rAAV vector provides a gene targeting substrate and a second vector expresses the nuclease that creates a DSB in the target gene. The frequencies of gene targeting that we achieved with relatively low MOIs suggest that combining rAAV vectors with DSBs is a promising strategy to broaden the application of gene targeting

Outcomes for Older Telecare Recipients: The Importance of Assessments

The article explores both telecare in relation to its composition of assistive technologies, including sensors; and associated services that use such technologies as a means by which, often vulnerable, people can obtain help through their activation - with signals being routed to monitoring centres. The context is one where there are changes to such technologies and ongoing growth in the use of telecare services - despite there being no indicated benefits from a major study (the Whole System Demonstrators). The 'curious' investment in such technologies and services by Adult Social Care Departments in England is investigated through an interview survey that elicited over 100 valid responses. Iy gave particular attention to the assessment process by which effective targeting (to those who would be most likely to benefit) would, it had been assumed, have taken place. Key outcomes point to needed improvements to social care practice - including the need to balance a narrow focus on risk (determined in a largely top-down way) with other telecare offerings that could more proactively address (e.g. loneliness) and involve the user more proactively in relation to technology and service options. The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Summary This article explores the role of telecare assessment, review and staff training in meeting the needs of older people living at home. Using original empirical data obtained from an online survey of English local authorities it reveals considerable variation in assessment and review practice and in training given to social work and other staff who assess and review, which may impact on outcomes for telecare users. The study findings are situated within an English policy context and earlier findings from a large, government funded randomised controlled trial. This trial concluded that telecare did not lead to better outcomes for users. Findings Our survey findings suggest that it may be the way in which telecare is used, rather than telecare itself that shapes outcomes for people who use it, and that ‘sub-optimal’ outcomes from telecare may be linked to how telecare is adopted, adapted and used; and that this is influenced by staff training, telecare availability and a failure to regard telecare as a complex intervention. Application The findings may help to reconcile evidence which suggests that telecare does not deliver better outcomes and local authority responses to this which either discount or contest its value. The article suggests that to use telecare to achieve optimal outcomes for older people, social workers, care managers and other professionals involved in assessing for telecare will need to be given enhanced training opportunities, and their employers will need to perceive telecare as a complex intervention rather than simply a ‘plug and play’ solution