853 research outputs found

    Group Work, Interlanguage Talk and Second Language Acquisition

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    The use of group work in classroom second language learning has long been supported by sound pedagogical arguments. Recently, however, a psycholinguistic rationale for group work has emerged from second language acquisition research on nonnative speaker/non-native speaker conversation, or interlanguage talk. Provided careful attention is paid to the structure of tasks students work on together, the negotiation work possible in group work makes it an attractive alternative to the teacher-led, "lockstep" mode, and a viable classroom substitute for individual conversations with native speakers

    Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom

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    Objectives: To identify changes since 1994 in the prevalence of resistance to anti-HIV drugs in primary HIV-1 infections in the United Kingdom. Design: Retrospective and prospective assessment of viruses obtained from people recently infected with HIV. Setting: Multiple centres (patients enrolled in the UK register of seroconverters) and a single large HIV clinic (active case ascertainment). Participants: 69 patients infected with HIV between June 1994 and August 2000. Main outcome measures: Prevalence of key mutations associated with drug resistance in the reverse transcriptase and protease genes of HIV-1, by year of infection. Results: Between June 1994 and August 2000, 10 (14%) of 69 newly infected patients had one or more key HIV-1 mutations associated with drug resistance. The risk of being infected with drug resistant virus increased over time (adjusted relative risk per year 1.74 (95% confidence interval 0.93 to 3.27), P=0.06). The estimated prevalence of drug resistance in those infected in 2000 was 27% (12% to 48%). Conclusions: Transmission of drug resistant HIV-1 in the United Kingdom seems to be increasing. New approaches to encourage safer sexual behaviour in all sectors of the population are urgently needed. What is already known on this topic: The emergence of HIV drug resistance in patients receiving antiretroviral therapy is common. Transmission of virus variants resistant to anti-HIV drugs has been documented. What this paper adds: The prevalence of transmitted HIV drug resistance in the United Kingdom is increasing, exceeding 20% in 2000. New approaches to encourage safer sexual behaviour are urgently needed

    A Prospective Randomized Comparison of Patient Specific Instruments with Standard TKA Instrumentation

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    Introduction: Patient specific instruments (PSI), an alternative to standard total knee arthroplasty (TKA) technology, have shown mixed results regarding effectiveness in previous studies. This study evaluated the accuracy of the predicted PSI plan, compared incremental cost savings with PSI, and compared outcomes of PSI and standard TKA patients. Patients and Methods: This randomized, prospective feasibility study included 19 primary TKA patients receiving a cruciate-retaining cemented prosthesis from a single surgeon (DCA). 9 patients randomized to PSI received a pre-operative knee MRI for PSI fabrication using proprietary software.10 standard TKAs were completed. Operative data collected included operating times, implant details, femoral (medial/lateral distal and posterior) and tibial (medial/lateral) resections, and instrument trays used. Hospitalization data collected included length of stay, blood loss, drain output, and transfusions. SF-36 and WOMAC scores, routine radiographic analysis, and femoral-tibial angles were collected pre- and post-operatively. Costs of operating room use and anesthesia, implants, and hospitalization were collected. Statistical analyses included t-tests and chi-square tests. Results: All implant sizes matched surgical team adjusted PSI software plans. Flexion gap resection (posterior medial/lateral femur) was extremely accurate (averagemm). Sagittal plane tibial component posterior slope was larger in PSI TKA (mean 7.3 degrees) than standard instrumentation (mean 4.2 degrees) (p0.05). There were no differences in operating room times or hospitalization data, and there were no significant differences in functional outcomes between the two groups (p\u3e0.05). PSI patients used 4 fewer instrument trays per case (p\u3c0.0001). Conclusion: PSI TKA demonstrated outstanding accuracy in bone resection when compared with the pre-operative plan, and resulted in appropriate limb and component alignment with primary TKA. The number of instrument trays used in PSI TKA was significantly less than standard TKA, which led to less cost for instrument sterilization and assembly

    The State of the Great Central Valley -- Public Health and Access to Care

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    Part of a series that provides various quality of life indicators for California's Central Valley. Examines public health and access to health care in the region. Focuses on maternal and child health, senior health, and chronic and communicable diseases

    Make Art Real

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    The Make Art Real project aims to introduce new audiences to the arts. It supports Theme II of VCU’s Quest for Distinction by promoting and fostering creative expression through innovative collaborations. The project involves displaying existing connections between art and non-art disciplines, as well as making new connections. These unusual pairings are then placed on exhibition through a lunch-time lecture series named “Unexpected_Connections,” which allow faculty, staff, and students to lead and participate in discussions about the reality of art. The lecture series is the first sustainable and reoccurring program to be held in the Depot building, a multidisciplinary facility which is intended to foster interdisciplinary collaborations. The targeted audience includes faculty, staff, students, and members of the greater VCU community

    NASA-Navy Telemedicine: Autogenic Feedback Training Exercises for Motion Sickness

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    Airsickness is the most significant medical condition affecting naval aviation training. A 2001 study showed that airsickness was reported in 81% of naval aviation students and was associated with 82% of below average flight scores. The cost to a single training air-wing was over 150,000annuallyforfuelandmaintenancecostsalone.ResistentcasesaresenttotheNavalAerospaceMedicalInstitute(NAMI)forevaluationanddesensitizationintheselfpacedairsicknessdesensitization(SPAD)program.Thisapproachis75150,000 annually for fuel and maintenance costs alone. Resistent cases are sent to the Naval Aerospace Medical Institute (NAMI) for evaluation and desensitization in the self-paced airsickness desensitization (SPAD) program. This approach is 75% successful, but can take up to 8 weeks at a significant travel cost. NASA Ames Research Center's Autogenic Feedback Training Exercises (AFTE) uses physiological and biofeedback training for motion sickness prevention. It has a remote capability that has been used from Moffett Field, CA to Atlanta, GA . AFTE is administered in twelve (30-minute) training sessions. The success rate for the NASA AFTE program has been over 85%. Methods: Implementation Phases: Phase I: Transfer NASA AFTE to NAMI; NASA will remotely train aviation students at NAMI. Phase II: NAMI-centered AFTE application with NASA oversight. Phase III: NAMI-centered AFTE to remotely train at various Navy sites. Phase IV: NAMI to offer Tri-service application and examine research opportunities. Results: 1. Use available telemedicine connectivity between NAMI and NASA. 2. Save over 2,000 per student trained. 3. Reduce aviation training attrition. 4. Provide standardization of multi-location motion sickness training. 5. Future tri-service initiatives. 6. Data to NASA and Navy for QA and research opportunities

    Pre-operative Emotional Health Affects Post-operative Patient Function but not Patient Satisfaction Following Primary Total Hip Arthroplasty

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    Introduction: Total hip (THA) and knee (TKA) arthroplasty are highly successful treatments for end-stage arthritis. However, a subset of patients experience suboptimal post-operative gain in function. 1, 2 Previous studies have shown that pre-operative emotional health influences outcomes after TKA,3 but there is limited evidence on THA patients. We hypothesized that pre-operative emotional health does not affect patient satisfaction in THA patients. Methods: A secondary analysis of an existing registry at UMass of primary THA patients between 2008 and 2011 was conducted. Baseline demographic, clinical, emotional health (SF-36 MCS), and physical health (SF-36 PCS) data were collected electronically at the pre-operative visit. Post-operative SF-36 MCS, SF-36 PCS, and satisfaction scores were collected electronically between 6 months through 2 years follow-up. Bivariate analyses and multivariate logistic regression models were used. Results: The analysis included 316 primary THA patients with mean age 62±11 years, 55% female, mean BMI 30±5, mean PCS 31±8, and mean MCS 51±11. Patients with lower baseline emotional health scores reported significantly reduced mean post-operative physical function and emotional health (p45 (indicating excellent function, national norm = 50); whereas patients with baseline MCS≥50 had a mean 17±11 point increase in post-operative PCS with 71% of these patients reporting PCS\u3e45 (p\u3c0.001). Conclusion: In THA patients, post-operative emotional health and physical health are positively correlated with baseline emotional health, however post-operative patient satisfaction remains independent of baseline emotional health

    Institutional Critique: A Rhetorical Methodology for Change

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    We offer institutional critique as an activist methodology for changing institutions. Since institutions are rhetorical entities, rhetoric can be deployed to change them. In its effort to counter oppressive institutional structures, the field of rhetoric and composition has focused its attention chiefly on the composition classroom, on the department of English, and on disciplinary forms of critique. Our focus shifts the scene of action and argument to professional writing and to public discourse, using spatial methods adapted from postmodern geography and critical theory

    Accelerated Partial Breast Irradiation: Using the CyberKnife as the Radiation Delivery Platform in the Treatment of Early Breast Cancer

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    We evaluate the CyberKnife (Accuray Incorporated, Sunnyvale, CA, USA) for non-invasive delivery of accelerated partial breast irradiation (APBI) in early breast cancer patients. Between 6/2009 and 5/2011, nine patients were treated with CyberKnife APBI. Normal tissue constraints were imposed as outlined in the National Surgical Adjuvant Breast and Bowel Project B-39/Radiation Therapy Oncology Group 0413 (NSABP/RTOG) Protocol (Vicini and White, 2007). Patients received a total dose of 30 Gy in five fractions (group 1, n = 2) or 34 Gy in 10 fractions (group 2, n = 7) delivered to the planning treatment volume (PTV) defined as the clinical target volume (CTV) +2 mm. The CTV was defined as either the lumpectomy cavity plus 10 mm (n = 2) or 15 mm (n = 7). The cavity was defined by a T2-weighted non-contrast breast MRI fused to a planning non-contrast thoracic CT. The CyberKnife Synchrony system tracked gold fiducials sutured into the cavity wall during lumpectomy. Treatments started 4–5 weeks after lumpectomy. The mean PTV was 100 cm3 (range, 92–108 cm3) and 105 cm3 (range, 49–241 cm3) and the mean PTV isodose prescription line was 70% for groups 1 and 2, respectively. The mean percent of whole breast reference volume receiving 100 and 50% of the dose (V100 and V50) for group 1 was 11% (range, 8–13%) and 23% (range, 16–30%) and for group 2 was 11% (range, 7–14%) and 26% (range, 21–35.0%), respectively. At a median 7 months follow-up (range, 4–26 months), no acute toxicities were seen. Acute cosmetic outcomes were excellent or good in all patients; for those patients with more than 12 months follow-up the late cosmesis outcomes were excellent or good. In conclusion, the lack of observable acute side effects and current excellent/good cosmetic outcomes is promising. We believe this suggests the CyberKnife is a suitable non-invasive radiation platform for delivering APBI with achievable normal tissue constraints
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