Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort

Background: Metabolic syndrome (MetS) is a highly prevalent and harmful medical disorder often comorbid with psychosis where it can contribute to cardiovascular complications. As immune dysfunction is a key shared component of both MetS and schizophrenia (SZ), this study investigated the relationship between immune alterations and MetS in patients with SZ, whilst controlling the impact of confounding clinical characteristics including psychiatric symptoms and comorbidities, history of childhood maltreatment and psychotropic treatments. Method: A total of 310 patients meeting DSM-IV criteria for SZ or schizoaffective disorders (SZA), with or without MetS, were systematically assessed and included in the FondaMental Advanced Centers of Expertise for Schizophrenia (FACE-SZ) cohort. Detailed clinical characteristics of patients, including psychotic symptomatology, psychiatric comorbidities and history of childhood maltreatment were recorded and the serum levels of 18 cytokines were measured. A penalized regression method was performed to analyze associations between inflammation and MetS, whilst controlling for confounding factors. Results: Of the total sample, 25% of patients had MetS. Eight cytokines were above the lower limit of detection (LLOD) in more than 90% of the samples and retained in downstream analysis. Using a conservative Variable Inclusion Probability (VIP) of 75%, we found that elevated levels of interleukin (IL)-6, IL-7, IL-12/23 p40 and IL-16 and lower levels of tumor necrosis factor (TNF)-α were associated with MetS. As for clinical variables, age, sex, body mass index (BMI), diagnosis of SZ (not SZA), age at the first episode of psychosis (FEP), alcohol abuse, current tobacco smoking, and treatment with antidepressants and anxiolytics were all associated with MetS. Conclusion: We have identified five cytokines associated with MetS in SZ suggesting that patients with psychotic disorders and MetS are characterized by a specific “immuno-metabolic” profile. This may help to design tailored treatments for this subgroup of patients with both psychotic disorders and MetS, taking one more step towards precision medicine in psychiatry. © 2022 The AuthorsImmuno-Génétique, Inflammation, retro-Virus, Environnement : de l'étiopathogénie des troubles psychotiques aux modèles animauxRéseau d'Innovation sur les Voies de Signalisation en Sciences de la Vi

Long-time fluctuations of off-diagonal GMI-based magnetometers

International audienceThis paper presents the measurement of long-time equivalent magnetic field fluctuations. It was obtained with a low noise off-diagonal GMI magnetometer. Acquisitions are conducted with a dedicated acquisition system. The GMI sensor principle and associated noise sources are reminded. Furthermore, the noise model is extended to include the impact of the very low frequency drift of the associated GMI impedance. The homemade GMI magnetometer and the used high dynamic analog to digital converter board are described. The obtained performances show a peak to peak fluctuations of 10 nTpp and a drift of 20 nT/h during 4.5 hours after a transient response. Results are compared, in real time, to a commercial flux gate magnetometer

Mesure de la partie imaginaire de la susceptibilité magnétique de capteurs MIG - Application à l'évaluation de leur bruit en 1/f

Récemment, un modèle du bruit intrinsèque du capteur MIG aux basses fréquences a été proposé suggérant que le bruit excédentaire serait induit par les fluctuations thermiques de l’aimantation et donc, lié à la partie imaginaire (dissipative), χ’’, de sa susceptibilité magnétique circonférentielle. Ce modèle permet de rendre compte d’un comportement en bruit dit en 1/f aux basses fréquences si la valeur de χ’’(f) apparait indépendante de la fréquence. Dans le but de valider ce modèle, nous avons étudié la dépendance en fréquence de ce terme par deux voies de mesures. L’analyse despremiers résultats expérimentaux montre qu’il est possible de prédire dans une certaine mesure le niveau de bruit magnétique de ces dispositifs aux basses fréquences