Drenaje Percutáneo de Absceso Renal en Niños: Caso Clínico

Indexación: ScieloRenal abscesses in children are rare. Percutaneous draining is a useful tool, frequently used among adults. The objective of this presentation is to present a pediatric case of a percutaneous-drained renal abscess. Patients and Methods: A 9 year old girl with a history of recurring acute left pyelonephritis was admitted for a new episode, which evolved into a 4.6 cm renal abscess, detected on a sonogram. Antibiotic treatment was effective, resulting in clinical and image resolution. Ten days post treatment, the abscess recurred, this time it was treated with an aspiration punction and antibiotics, with a good clinical response. Follow up image showed resolution. Again, followup showed a recurrence of the abscess. This time a percutaneous drain was utilized, with complete clinical and image resolution. Various therapeutic alternatives, and the use of drains in children are discussed.Los abscesos renales en niños son infrecuentes. El tratamiento con drenaje percutáneo es una herramienta útil, y frecuentemente utilizada en adultos. El objetivo es presentar la experiencia en drenaje per-cutáneo de un absceso renal en paciente pediátrico. Paciente y Método: Se reporta el caso de una paciente de 9 años, de sexo femenino, con antecedente de pielonefritis aguda izquierda a repetición. Presenta un cuadro de pielonefritis aguda complicada, evolucionando con un absceso renal de 4,6 cm, detectado por ecotomo-grafía. Es tratada con esquema antibiótico biasociado, con mejoría clínica e imagenológica. Evoluciona con reproducción del absceso a los 10 días post tratamiento, manejándose en esta ocasión con punción aspirativa y antibióticos, obteniendo buena respuesta clínica y resolución imagenológica. Posterior al tratamiento presenta recidiva del absceso, tratándose en esta ocasión con drenaje percutáneo, con mejoría clínica y radiológica definitiva, y sin presentar reproducción del absceso en el seguimiento alejado. Se discuten las distintas alternativas terapéuticas y el uso del drenaje percutáneo en el manejo del absceso renal en los niños. Conclusión: El drenaje percutáneo del absceso renal se debe tener presente como una alternativa a la cirugía en el tratamiento de abscesos renales en casos seleccionados.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062010000200008&nrm=is

Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort

Background: Metabolic syndrome (MetS) is a highly prevalent and harmful medical disorder often comorbid with psychosis where it can contribute to cardiovascular complications. As immune dysfunction is a key shared component of both MetS and schizophrenia (SZ), this study investigated the relationship between immune alterations and MetS in patients with SZ, whilst controlling the impact of confounding clinical characteristics including psychiatric symptoms and comorbidities, history of childhood maltreatment and psychotropic treatments. Method: A total of 310 patients meeting DSM-IV criteria for SZ or schizoaffective disorders (SZA), with or without MetS, were systematically assessed and included in the FondaMental Advanced Centers of Expertise for Schizophrenia (FACE-SZ) cohort. Detailed clinical characteristics of patients, including psychotic symptomatology, psychiatric comorbidities and history of childhood maltreatment were recorded and the serum levels of 18 cytokines were measured. A penalized regression method was performed to analyze associations between inflammation and MetS, whilst controlling for confounding factors. Results: Of the total sample, 25% of patients had MetS. Eight cytokines were above the lower limit of detection (LLOD) in more than 90% of the samples and retained in downstream analysis. Using a conservative Variable Inclusion Probability (VIP) of 75%, we found that elevated levels of interleukin (IL)-6, IL-7, IL-12/23 p40 and IL-16 and lower levels of tumor necrosis factor (TNF)-α were associated with MetS. As for clinical variables, age, sex, body mass index (BMI), diagnosis of SZ (not SZA), age at the first episode of psychosis (FEP), alcohol abuse, current tobacco smoking, and treatment with antidepressants and anxiolytics were all associated with MetS. Conclusion: We have identified five cytokines associated with MetS in SZ suggesting that patients with psychotic disorders and MetS are characterized by a specific “immuno-metabolic” profile. This may help to design tailored treatments for this subgroup of patients with both psychotic disorders and MetS, taking one more step towards precision medicine in psychiatry. © 2022 The AuthorsImmuno-Génétique, Inflammation, retro-Virus, Environnement : de l'étiopathogénie des troubles psychotiques aux modèles animauxRéseau d'Innovation sur les Voies de Signalisation en Sciences de la Vi

Long-time fluctuations of off-diagonal GMI-based magnetometers

International audienceThis paper presents the measurement of long-time equivalent magnetic field fluctuations. It was obtained with a low noise off-diagonal GMI magnetometer. Acquisitions are conducted with a dedicated acquisition system. The GMI sensor principle and associated noise sources are reminded. Furthermore, the noise model is extended to include the impact of the very low frequency drift of the associated GMI impedance. The homemade GMI magnetometer and the used high dynamic analog to digital converter board are described. The obtained performances show a peak to peak fluctuations of 10 nTpp and a drift of 20 nT/h during 4.5 hours after a transient response. Results are compared, in real time, to a commercial flux gate magnetometer

Etude du bruit aux basses fréquences dans les magnétomètres à base de Magnéto-Impédance Géante

International audienceActuellement, les performances en terme de bruit équivalent en champ des magnétomètres à base de Magneto Impédance Géante (en mode off-diagonal) sont limitées par le conditionnement électronique et par la sensibilité du capteur en zone de bruit blanc. Pour une fréquence d’excitation du capteur de 1 MHz, nous atteignons un niveau de bruit inférieur à 1 en zone de bruit blanc et de 15-20 à 1 Hz. A basse fréquence, le bruit est dit excédentaire et présente un spectre dit en 1/f, en dessous de quelques dizaines de Hertz. Dans le but d’améliorer les performances en bruit de ces magnétomètres, il est nécessaire de comprendre et de localiser l’origine de ce bruit aux basses fréquences. Pour ce faire, nous avons évalué le degré de cohérence entre des signaux partageant des sources de bruit communes puis en séparant la chaine d’amplification en plusieurs voies de mesure. Ce degré de cohérence est mesuré par la fonction de cohérence. Cette approche doit permettre d’affiner l’évaluation des différentes contributions des sources de bruit présentes sur la chaîne de mesure