Preparation and study of synthetic protein- like materials for high performance adhesive systems Final report

Preparation and study of synthetic protein like materials for high performance adhesive system

Predicting improvement in gait after stroke: a longitudinal prospective study

0.001). CONCLUSIONS: Improvement in standing balance control is more important than improvement in leg strength or synergism to achieve improvement in walking ability, whereas reduction in visuospatial inattention is independently related to improvement of gait. Finally, time itself is an independent covariate that is negatively associated with change on FAC, suggesting that most pronounced improvements occur earlier after strok

Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity

The ExPortal protein secretion organelle in Streptococcus pyogenes is an anionic phospholipid-containing membrane microdomain enriched in Sec translocons and postsecretion protein biogenesis factors. Polymyxin B binds to and disrupts ExPortal integrity, resulting in defective secretion of several toxins. To gain insight into factors that influence ExPortal organization, a genetic screen was conducted to select for spontaneous polymyxin B-resistant mutants displaying enhanced ExPortal integrity. Whole-genome resequencing of 25 resistant mutants revealed from one to four mutations per mutant genome clustered primarily within a core set of 10 gene groups. Construction of mutants with individual deletions or insertions demonstrated that 7 core genes confer resistance and enhanced ExPortal integrity through loss of function, while 3 were likely due to gain of function and/or combinatorial effects. Core resistance genes include a transcriptional regulator of lipid biosynthesis, several genes involved in nutrient acquisition, and a variety of genes involved in stress responses. Two members of the latter class also function as novel regulators of the secreted SpeB cysteine protease. Analysis of the most frequently isolated mutation, a single nucleotide deletion in a track of 9 consecutive adenine residues in pstS, encoding a component of a high-affinity P(i) transporter, suggests that this sequence functions as a molecular switch to facilitate stress adaptation. Together, these data suggest the existence of a membrane stress response that promotes enhanced ExPortal integrity and resistance to cationic antimicrobial peptides

Transplanting Kidneys Without Points for HLA‐B Matching: Consequences of the Policy Change

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87103/1/j.1600-6143.2011.03606.x.pd

Spatio-temporal distribution and target species of longline fish eries off Southeastern/Southern Brazil between 2000 and 2011

In the presente study, cluster analysis was performed to classify 1080 interviews with captains of national pelagic longline fleet (2000 to 2011), and 38 trips of the chartered fleet (2003 to 2008), in relation to the composition of species landed. For the national fleet 4 groups were identified: 1 - Albacores, 2 - Blue shark, 3 - Swordfish, and 4 - Dolphinfish. For the chartered fleet 3 groups were identified: 1 - Swordfish, 2 - Blue shark, and 3 - Albacores. The results indicated that part of the national fleet change their strategies according to the availability of the target species and market demand (internal and external). A part of the fleet from Espírito Santo state operates in the region between December and March, exclusively to capture dolphinfish. The chartered fleet differed from the national one as regards the fishing areas of each target species, mainly as regards swordfish and blue shark. Despite the great difference in the data sets, it is evident that both the national and the chartered fleets operated in accordance with their peculiarities and technological development, adopting strategies that optimize catches and net profits per trip.No presente estudo, uma análise de agrupamento foi realizada para classificar 1080 entrevistas com mestres da frota nacional de espinhel pelágico (2000 à 2011), e 38 embarques da frota estrangeira arrendada (2003 a 2008), em relação à composição das espécies desembarcadas. Para a frota nacional, foram identificados 4 grupos: 1 - Albacoras; 2 - Tubarãoazul; 3 - Meca; e 4 - Dourado. Para a frota estrangeira arrendada foram identificados 3 grupos: 1 - Meca; 2 - Tubarão-azul; e 3 - Albacoras. Os resultados indicam que parte da frota nacional altera suas estratégias de pesca de acordo com a disponibilidade da espéciealvo e pela demanda do mercado (interno e externo). Uma parcela da frota oriunda do Espírito Santo opera na região durante alguns meses de verão (dezembro a março), exclusivamente na captura do dourado. Para a frota estrangeira arrendada, ocorrem diferenças principalmente nas áreas de pesca para cada uma das espécies, sendo a frota direcionada principalmente para a captura da meca e tubarão-azul. Apesar da grande diferença no conjunto de dados, fica evidente que a frota nacional e estrangeira operam de acordo com suas particularidades e desenvolvimento tecnológico, adotando estratégias que otimizem as capturas e os lucros líquidos por viagem

The Survival Benefit of Liver Transplantation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73611/1/j.1600-6143.2004.00703.x.pd

Is oxidative stress MYC’s Achilles heel?

No abstract available

Language comparison via network topology

Modeling relations between languages can offer understanding of language characteristics and uncover similarities and differences between languages. Automated methods applied to large textual corpora can be seen as opportunities for novel statistical studies of language development over time, as well as for improving cross-lingual natural language processing techniques. In this work, we first propose how to represent textual data as a directed, weighted network by the text2net algorithm. We next explore how various fast, network-topological metrics, such as network community structure, can be used for cross-lingual comparisons. In our experiments, we employ eight different network topology metrics, and empirically showcase on a parallel corpus, how the methods can be used for modeling the relations between nine selected languages. We demonstrate that the proposed method scales to large corpora consisting of hundreds of thousands of aligned sentences on an of-the-shelf laptop. We observe that on the one hand properties such as communities, capture some of the known differences between the languages, while others can be seen as novel opportunities for linguistic studies

Determinants of Discard of Expanded Criteria Donor Kidneys: Impact of Biopsy and Machine Perfusion

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73820/1/j.1600-6143.2008.02157.x.pd