136 research outputs found
TransitionâMetalâFree CrossâCoupling of Benzothiophenes and Styrenes in a Stereoselective Synthesis of Substituted (E,Z)â1,3âDienes
A transition metalâfree oneâpot stereoselective approach to substituted (E,Z)â1,3âdienes was developed by using an interrupted Pummerer reaction/ligandâcoupling strategy. Readily available benzothiophene Sâoxides, which can be conveniently prepared by oxidation of the parent benzothiophenes, undergo Pummerer coupling with styrenes. Reaction of the resultant sulfonium salts with alkyllithium/magnesium reagents generates underexploited hypervalent sulfurane intermediates that undergo selective ligand coupling, resulting in dismantling of the benzothiophene motif and the formation of decorated (E,Z)â1,3âdienes
Fine scale depth regulation of invertebrate larvae around coastal fronts
Vertical migrations of zooplankters have been widely described, but their
active movements through shallow, highly dynamic water columns within the inner
shelf may be more complex and difficult to characterize. In this study,
invertebrate larvae, currents, and hydrographic variables were sampled at
different depths during and after the presence of fronts on three different
cruises off the southern coast of South Africa. Internal wave dynamics were
observed in the hydrographic data set but also through satellite imagery,
although strong surface convergent currents were absent and thermal
stratification was weak. During the first two cruises, fronts were more
conspicuous and they preceded strong onshore currents at depth which developed
with the rising tide. Vertical distributions of larvae changed accordingly,
with higher abundances at these deep layers once the front disappeared. The
third cruise was carried out during slack tides, the front was not conspicuous,
deep strong onshore currents did not occur afterward and larval distributions
did not change consistently through time. Overall, the vertical distributions
of many larval taxa matched the vertical profiles of shoreward currents and
multivariate analyses revealed that these flows structured the larval
community, which was neither influenced by temperature nor chlorophyll. Thus,
the ability to regulate active vertical positioning may enhance shoreward
advection and determine nearshore larval distributions
The role of fetal, infant, and childhood nutrition in the timing of sexual maturation
Puberty is a crucial developmental stage in the life span, necessary to achieve reproductive and somatic maturity. Timing of puberty is modulated by and responds to central neurotransmitters, hormones, and environmental factors leading to hypothalamic-pituitary-gonadal axis maturation. The connection between hormones and nutrition during critical periods of growth, like fetal life or infancy, is fundamental for metabolic adaptation response and pubertal development control and prediction. Since birth weight is an important indicator of growth estimation during fetal life, restricted prenatal growth, such as intrauterine growth restriction (IUGR) and small for gestational age (SGA), may impact endocrine system, affecting pubertal development. Successively, lactation along with early life optimal nutrition during infancy and childhood may be important in order to set up timing of sexual maturation and provide successful reproduction at a later time. Sexual maturation and healthy growth are also influenced by nutrition requirements and diet composition. Early nutritional surveillance and monitoring of pubertal development is recommended in all children, particularly in those at risk, such as the ones born SGA and/or IUGR, as well as in the case of sudden weight gain during infancy. Adequate macro and micronutrient intake is essential for healthy growth and sexual maturity
The time in science: An interdisciplinary laboratorial approach
In order to promote problem-based and active learning in the physics laboratory, we designed a flipped classroom focused on the Franck-Hertz experiment. The flipped classroom approach moves course content from the classroom to homework and uses class time for engaging activities and problem solving. This constructivist approach to teaching is an effective means of student-centred collaboration and it can promote active learning, enhance critical thinking and obtain the maximum use of student-faculty time together. We report preliminary results of the flipped classroom approach to a laboratory and how it worked in the context of a small group of students in a physics course. © Published under licence by IOP Publishing Ltd
Dynamical completions of generalized O'Raifeartaigh models
We present gauge theory completions of Wess-Zumino models admitting
supersymmetry breaking vacua with spontaneously broken R-symmetry. Our models
are simple deformations of generalized ITIY models, a supersymmetric theory
with gauge group Sp(N), N+1 flavors plus singlets, with a modified tree level
superpotential which explicitly breaks (part of) the global symmetry. Depending
on the nature of the deformation, we obtain effective O'Raifeartaigh-like
models whose pseudomoduli space is locally stable in a neighborhood of the
origin of field space, or in a region not including it. Hence, once embedded in
direct gauge mediation scenarios, our models can give low energy spectra with
either suppressed or unsuppressed gaugino mass.Comment: 21 pages, 1 figure; v3: reference adde
Early Life Microbiota Colonization at Six Months of Age: A Transitional Time Point
Background: Early life gut microbiota is involved in several biological processes, particularly metabolism, immunity, and cognitive neurodevelopment. Perturbation in the infant's gut microbiota increases the risk for diseases in early and later life, highlighting the importance of understanding the connections between perinatal factors with early life microbial composition. The present research paper is aimed at exploring the prenatal and postnatal factors influencing the infant gut microbiota composition at six months of age.
Methods: Gut microbiota of infants enrolled in the longitudinal, prospective, observational study "A.MA.MI" (Alimentazione MAmma e bambino nei primi MIlle giorni) was analyzed. We collected and analyzed 61 fecal samples at baseline (meconium, T0); at six months of age (T2), we collected and analyzed 53 fecal samples. Samples were grouped based on maternal and gestational weight factors, type of delivery, type of feeding, time of weaning, and presence/absence of older siblings. Alpha and beta diversities were evaluated to describe microbiota composition. Multivariate analyses were performed to understand the impact of the aforementioned factors on the infant's microbiota composition at six months of age.
Results: Different clustering hypotheses have been tested to evaluate the impact of known metadata factors on the infant microbiota. Neither maternal body mass index nor gestational weight gain was able to determine significant differences in infant microbiota composition six months of age. Concerning the type of feeding, we observed a low alpha diversity in exclusive breastfed infants; conversely, non-exclusively breastfed infants reported an overgrowth of Ruminococcaceae and Flavonifractor. Furthermore, we did not find any statistically significant difference resulting from an early introduction of solid foods (before 4 months of age). Lastly, our sample showed a higher abundance of clostridial patterns in firstborn babies when compared to infants with older siblings in the family.
Conclusion: Our findings showed that, at this stage of life, there is not a single factor able to affect in a distinct way the infants' gut microbiota development. Rather, there seems to be a complex multifactorial interaction between maternal and neonatal factors determining a unique microbial niche in the gastrointestinal tract
Prenatal and postnatal determinants in shaping offspring's microbiome in the first 1000 days: Study protocol and preliminary results at one month of life
Background: Fetal programming during in utero life defines the set point of physiological and metabolic responses that lead into adulthood; events happening in "the first 1,000 days" (from conception to 2-years of age), play a role in the development of non-communicable diseases (NCDs). The infant gut microbiome is a highly dynamic organ, which is sensitive to maternal and environmental factors and is one of the elements driving intergenerational NCDs' transmission. The A.MA.MI (Alimentazione MAmma e bambino nei primi MIlle giorni) project aims at investigating the correlation between several factors, from conception to the first year of life, and infant gut microbiome composition. We described the study design of the A.MA.MI study and presented some preliminary results. Methods: A.MA.MI is a longitudinal, prospective, observational study conducted on a group of mother-infant pairs (n = 60) attending the Neonatal Unit, Fondazione IRCCS Policlinico San Matteo, Pavia (Italy). The study was planned to provide data collected at T0, T1, T2 and T3, respectively before discharge, 1,6 and 12 months after birth. Maternal and infant anthropometric measurements were assessed at each time. Other variables evaluated were: Pre-pregnancy/gestational weight status (T0), maternal dietary habits/physical activity (T1-T3); infant medical history, type of feeding, antibiotics/probiotics/supplements use, environment exposures (e.g cigarette smoking, pets, environmental temperature) (T1-T3). Infant stool samples were planned to be collected at each time and analyzed using metagenomics 16S ribosomal RNA gene sequence-based methods. Results: Birth mode (cesarean section vs. vaginal delivery) and maternal pre pregnancy BMI (BMI < 25 Kg/m2 vs. BMI â„ 25 Kg/m2), significant differences were found at genera and species levels (T0). Concerning type of feeding (breastfed vs. formula-fed), gut microbiota composition differed significantly at genus and species level (T1). Conclusion: These preliminary and explorative results confirmed that pre-pregnancy, mode of delivery and infant factors likely impact infant microbiota composition at different levels. Trial registration: ClinicalTrials.gov identifier: NCT04122612
Exploring Holographic General Gauge Mediation
We study models of gauge mediation with strongly coupled hidden sectors,
employing a hard wall background as an holographic dual description. The
structure of the soft spectrum depends crucially on the boundary conditions one
imposes on bulk fields at the IR wall. Generically, vector and fermion
correlators have poles at zero momentum, leading to gauge mediation by massive
vector messengers and/or generating Dirac gaugino masses. Instead, non-generic
choices of boundary conditions let one cover all of GGM parameter space.
Enriching the background with R-symmetry breaking scalars, the SSM soft term
structure becomes more constrained and similar to previously studied top-down
models, while retaining the more analytic control the present bottom-up
approach offers.Comment: 28 pages, 4 figures; v2: typos corrected and refs adde
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