14 research outputs found
Idiopathic Pulmonary Fibrosis (IPF) incidence and prevalence in Italy
Background: Studies of Idiopathic Pulmonary Fibrosis (IPF) epidemiology show regional variations of
incidence and prevalence; no epidemiological studies have been carried out in Italy. Objective: To determine incidence
and prevalence rates of IPF in the population of a large Italian region.Methods: in this cross-sectional study
study data were collected on all patients of 18 years of age and older admitted as primary or secondary idiopathic
fibrosing alveolitis (ICD9-CM 516.3) to Lazio hospitals, from 1/1/2005 to 31/12/2009, using regional hospital
discharge, population and cause of death databases. Reporting accuracy was assessed on a random sample of hospital
charts carrying the ICD9-CM 516.3, 516.8, 516.9 and 515 codes, by reviewing radiology and pathology
findings to define cases as IPF âconfidentâ, âpossibleâ or âinconsistentâ. Results: Annual prevalence and incidence
of IPF were estimated at 25.6 per 100,000 and 7.5 per 100,000 using the ICD9-CM code 516.3 without chart
audit while they were estimated at 31.6 per 100,000 and at 9,3 per 100,000 for the IPF âconfidentâ definition after
hospital chart audit. Conclusion: The data provide a first estimate of IPF incidence in Italy and indicate that incidence
and prevalence in southern European regions may be similar to those observed in northern Europe and
North America. (Sarcoidosis Vasc Diffuse Lung Dis 2014; 31: 191-197
On the Relation Between Turnpike Properties for Finite and Infinite Horizon Optimal Control Problems
High chlorpyrifos resistance in Culex pipiens mosquitoes: strong synergy between resistance genes
International audienceWe investigated the genetic determinism of high chlorpyrifos resistance (HCR), a phenotype first described in 1999 in Culex pipiens mosquitoes surviving chlorpyrifos doses 1âmgâlâ1 and more recently found in field samples from Tunisia, Israel or Indian Ocean islands. Through chlorpyrifos selection, we selected several HCR strains that displayed over 10â000-fold resistance. All strains were homozygous for resistant alleles at two main loci: the ace-1 gene, with the resistant ace-1R allele expressing the insensitive G119S acetylcholinesterase, and a resistant allele of an unknown gene (named T) linked to the sex and ace-2 genes. We constructed a strain carrying only the T-resistant allele and studied its resistance characteristics. By crossing this strain with strains harboring different alleles at the ace-1 locus, we showed that the resistant ace-1R and the T alleles act in strong synergy, as they elicited a resistance 100 times higher than expected from a simple multiplicative effect. This effect was specific to chlorpyrifos and parathion and was not affected by synergists. We also examined how HCR was expressed in strains carrying other ace-1-resistant alleles, such as ace-1V or the duplicated ace-1D allele, currently spreading worldwide. We identified two major parameters that influenced the level of resistance: the number and the nature of the ace-1-resistant alleles and the number of T alleles. Our data fit a model that predicts that the T allele acts by decreasing chlorpyrifos concentration in the compartment targeted in insects