Longitudinal study of self-medication practices in 2nd year MBBS students through their internship

Background: Self-medication is common in medical students but few studies address the concern regarding knowledge of adverse drug reactions (ADRs) among them. None of the study compares the practice of self-medication among the same medical students as their level of education increases. Hence the study was planned to compare the pattern, source, reason of self- medication and assess the level of awareness about potential ADRs to the consumed drugs in medical students during second year through their internship.Methods: It was a longitudinal cross sectional questionnaire-based study conducted among under graduate second year MBBS students of a medical college and repeated during their internship few years later in order to avoid variability in questionnaire. Chi-square and Fischer’s exact test were used for testing statistical significance. p value less than 0.05 was considered to be statistically significant.Results: 80 students were present on the day of study during their IInd MBBS and 73 students during their internship. Comparatively more students self-medicated during their internship than during their IInd MBBS (68% vs 55%). Analgesics (56.8% and 80%) were most commonly used. 35(70%) of interns were aware of potential ADRs and was statistically very significant in comparison to their awareness during IInd MBBS [9(20.45%)]. Interns rely more on themselves (96%) for self-medication.Conclusions: The practice of self-medication begins early in the career of medical students and is carried forward into their future. Hence it is imperative to educate students regarding responsible self- medication very early in their curriculum

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In-beam internal conversion electron spectroscopy with the SPICE detector

The SPectrometer for Internal Conversion Electrons (SPICE) has been commissioned for use in conjunction with the TIGRESS $\gamma$-ray spectrometer at TRIUMF's ISAC-II facility. SPICE features a permanent rare-earth magnetic lens to collect and direct internal conversion electrons emitted from nuclear reactions to a thick, highly segmented, lithium-drifted silicon detector. This arrangement, combined with TIGRESS, enables in-beam $\gamma$-ray and internal conversion electron spectroscopy to be performed with stable and radioactive ion beams. Technical aspects of the device, capabilities, and initial performance are presented

Identification of the New Isotope \u3csup\u3e244\u3c/sup\u3eMd

In an experiment performed at Lawrence Berkeley National Laboratory\u27s 88-inch cyclotron, the isotope Md244 was produced in the Bi209(Ar40,5n) reaction. Decay properties of Md244 were measured at the focal plane of the Berkeley Gas-filled Separator, and the mass number assignment of A=244 was confirmed with the apparatus for the identification of nuclide A. The isotope Md244 is reported to have one, possibly two, α-decaying states with α energies of 8.66(2) and 8.31(2) MeV and half-lives of 0.4-0.1+0.4 and ∼6 s, respectively. Additionally, first evidence of the α decay of Bk236 was observed and is reported

High-Statistics β\u3csup\u3e+\u3c/sup\u3e/EC-Decay Study of \u3csup\u3e122\u3c/sup\u3eXe

Low-lying excited states of 122Xe have been studied via the β+/EC decay of 122Cs with the 8π γ-ray spectrometer at the TRIUMF Isotope Separator and Accelerator facility. The data collected have enabled the observation of new in-band transitions in the excited 0+ state bands. In addition, the 2+ members of the second 0+ and third 0+ state bands have been firmly confirmed by angular correlation analysis

Spectroscopy along flerovium decay chains. II. Fine structure in odd-A 289Fl

Fifteen correlated α-decay chains starting from the odd-A superheavy nucleus 289Fl were observed following the fusion-evaporation reaction 48Ca+244Pu. The results call for at least two parallel α-decay sequences starting from at least two different states of 289Fl. This implies that close-lying levels in nuclei along these chains have quite different spin-parity assignments. Further, observed α-electron and α-photon coincidences, as well as the α-decay fine structure along the decay chains, suggest a change in the ground-state spin assignment between 285Cn and 281Ds. Our experimental results, on the excited level structure of the heaviest odd-N nuclei to date, provide a direct testing ground for theory. This is illustrated by comparison with new nuclear structure calculations based on the symmetry-conserving configuration mixing theory

Prodrug Strategy for PSMA-targeted Delivery of TGX-221 to Prostate Cancer Cells

TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that TGX-221 has anti-proliferative activity against PTEN-deficient tumor cell lines including prostate cancers. The objective of this study was to develop an encapsulation system for parenterally delivering TGX-221 to the target tissue through a prostate-specific membrane aptamer (PSMAa10) with little or no side effects. In this study, PEG-PCL micelles were formulated to encapsulate the drug, and a prodrug strategy was pursued to improve the stability of the carrier system. Fluorescence imaging studies demonstrated that the cellular uptake of both drug and nanoparticles were significantly improved by targeted micelles in a PSMA positive cell line. The area under the plasma concentration time curve of the micelle formulation in nude mice was 2.27-fold greater than the naked drug, and the drug clearance rate was 17.5-fold slower. These findings suggest a novel formulation approach for improving site-specific drug delivery of a molecular-targeted prostate cancer treatment