Usefulness of Home Screening for Promoting Awareness of Impaired Glycemic Status and Utilization of Primary Care in a Low Socio-Economic Setting: A Follow-Up Study in Reunion Island

International audienceBackground: Low socioeconomic settings are characterized by high prevalence of diabetes and difficulty in accessing healthcare. In these contexts, proximity health services could improve healthcare access for diabetes prevention. Our primary objective was to evaluate the usefulness of home screening for promoting awareness of impaired glycemic status and utilization of primary care among adults aged 18-79 in a low socioeconomic setting. Methods: This follow-up study was conducted in 2015-2016 in Reunion Island, a French overseas department in the Indian Ocean. Enrollment and screening occurred on the same day at the home of participants (N = 907). Impaired glycemic status was defined as [glycated hemoglobin (HbA1c) ≥5.7%] OR [fasting capillary blood glucose (FCBG) ≥1.10 g/L] OR [HbA1c = 5.5-5.6% and FCBG = 1.00-1.09 g/L]. Medical, socio-cultural, and socioeconomic characteristics were collected via a face-to-face questionnaire. A one-month telephone follow-up survey was conducted to determine whether participants had consulted a general practitioner (GP) for confirmation of screening results. A multinomial polytomous logistic regression model was used to identify factors independently associated with non-use of GP consultation for confirmation of screening results and nonresponse to the telephone follow-up survey. Results: Prevalence of glycemic abnormalities was 46.0% (95% CI = 42.7-49.2%). Among participants with impaired glycemic status (N = 417), 77.7% (95% CI = 73.7-81.7%) consulted a GP for confirmation of screening results, 12.5% (95% CI = 9.3-15.6%) did not, and 9.8% failed to respond to the follow-up survey. Factors independently associated with nonuse of GP consultation for confirmation of screening results were self-reported unwillingness to consult a GP (adjusted odds ratio [OR]: 4.86, 95% CI = 1.70-13.84), usual GP consultation frequency of less than once a year (adjusted OR: 4.13, 95% CI = 1.56-10.97), and age 18-39 years (adjusted OR: 3.09, 95% CI = 1.46-6.57). Conclusion: Home screening for glycemic abnormalities is a useful proximity health service for diabetes prevention in low socioeconomic settings. Further efforts, including health literacy interventions, are needed to increase utilization of primary care

QUALITY OF LIFE TEN YEARS AFTER A CHIKUNGUNYA OUTBREAK : THE QOL-CHIK POPULATION-BASED STUDY ON REUNION ISLAND

67th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTHM), New Orleans, LA, OCT 28-NOV 01, 201

QUALITY OF LIFE TEN YEARS AFTER A CHIKUNGUNYA OUTBREAK : THE QOL-CHIK POPULATION-BASED STUDY ON REUNION ISLAND

67th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTHM), New Orleans, LA, OCT 28-NOV 01, 201

Évaluation de l’efficacité d’un programme d’activité physique individualisé,associé à une alimentation équilibrée enrichie en fruits et légumes, sur l’évolution de la masse grasse chez des femmes en surpoids ou obèses, dans le cadre de la prévention du diabète de type 2 (DT2) à la Réunion. Étude LIPOXmax-Réunion

International audienceL'activité physique (AP) régulière effectuée à une intensité correspondant au débit maximal d'oxydation lipidique (LIPOXmax) semble efficace sur la diminution de la masse grasse. Mais l'efficacité supérieure d'une AP au LIPOXmax par rapport à un autre type d'AP reste à démontrer. L'objectif de notre travail est de comparer l'efficacité de trois programmes d'AP de 5 mois sur la composition corporelle mesurée par DEXA, la faisabilité en population, l'observance

Q fever seroprevalence in parturient women: the EQRUN cross-sectional study on Reunion Island

International audienceBackground: Q fever (Coxiella burnetii infection) has been associated with adverse perinatal outcomes. After investigating the obstetrical importance of Q fever on Reunion island and demonstrating an association between incident Q fever and miscarriage, we conducted a cross-sectional serosurvey to assess the prevalence of Coxiella burnetii infection among parturient women. Methods: Between January 9 and July 24, 2014, within the level-4 maternity of Saint Pierre hospital and the level-1 maternity of Le Tampon, we proposed to screen all parturient women for Coxiella burnetii serology. Seropositivity was defined using indirect immunofluorescence for a dilution of phase 2 IgG titre ≥1:64. Further dilutions were chosen to discriminate recent or active infections from past or prevalent infections ( 90% of positive serologies corresponded to past infections or false positives. Seropositivity was associated with none of the abovementioned adverse perinatal outcomes, whether in unpaired or matched analyses on propensity score. Conclusion: The magnitude and the pattern of seroprevalence suggest that Q fever is endemic on Reunion island. In this context, we found no significant contribution of prevalent Coxiella burnetii infection to adverse pregnancy outcomes. Although reassuring, these data put in our endemic context, with a previously demonstrated increased risk of incident Q fever associated miscarriage, encourage us to protect pregnant women against the risk of new infection, periconceptional or early in pregnancy

Individualized Exercise Training at Maximal Fat Oxidation Combined with Fruit and Vegetable-Rich Diet in Overweight or Obese Women: The LIPOXmax-Réunion Randomized Controlled Trial.

Lifestyle combined interventions are a key strategy for preventing type-2 diabetes (T2DM) in overweight or obese subjects. In this framework, LIPOXmax individualized training, based on maximal fat oxidation [MFO], may be a promising intervention to promote fat mass (FM) reduction and prevent T2DM. Our primary objective was to compare three training programs of physical activity combined with a fruit- and vegetable-rich diet in reducing FM in overweight or obese women.A five months non-blinded randomized controlled trial (RCT) with three parallel groups in La Réunion Island, a region where metabolic diseases are highly prevalent.One hundred and thirty-six non-diabetic obese (body mass index [BMI]: 27-40 kg/m2) young women (aged 20-40) were randomized (G1: MFO intensity; G2: 60% of VO2-peak intensity; G3: free moderate-intensity at-home exercise following good physical practices).Anthropometry (BMI, bodyweight, FM, fat-free mass), glucose (fasting plasma glucose, insulin, HOMA-IR) and lipid (cholesterol and triglycerides) profiles, and MFO values were measured at month-0, month-3 and month-5.At month-5, among 109 women assessed on body composition, the three groups exhibited a significant FM reduction over time (G1: -4.1±0.54 kg; G2: -4.7±0.53 kg; G3: -3.5±0.78 kg, p<0.001, respectively) without inter-group differences (p = 0.135). All groups exhibited significant reductions in insulin levels or HOMA-IR index, and higher MFO values over time (p<0.001, respectively) but glucose control improvement was higher in G1 than in G3 while MFO values were higher in G1 than in G2 and G3. Changes in other outcome measures and inter-group differences were not significant.In our RCT the LIPOXmax intervention did not show a superiority in reducing FM in overweight or obese women but is associated with higher MFO and better glucose control improvements. Other studies are required before proposing LIPOXmax training for the prevention of T2DM in overweight or obese women.ClincialTrials.gov NCT01464073

Baseline exercise tests at inclusion for LIPOXmax-Réunion randomized controlled trial participants.

<p>Data are means ± SD. FFM: Fat Free Mass. HR: Heart Rate. RER: Respiratory Exchange Ratio. W: Power. MFO: Maximal Fat Oxidation. p-values refer to comparisons between the three groups by one-way ANOVA or Kruskal-Wallis non parametric tests (*).</p><p>Baseline exercise tests at inclusion for LIPOXmax-Réunion randomized controlled trial participants.</p

Post-hoc analysis (Repeated–measures ANOVA P values) for longitudinal evolution of metabolic characteristics (month-0, month-3 and month-5).

<p>HOMA-IR index: HOmeostasis Model Assessment estimated insulin resistance index. MFO: Maximal Fat Oxidation. FFM: Fat Free Mass. Repeated-measures ANOVA P values represent the main effects of time (t), g (group) and the interaction effect (time *group). Post-hoc analysis (G1 vs G2, G1 vs G3, G2 vs G3) was performed to compare groups two-by-two at p = 0.0167 significance level according to Bonferroni’s method.</p><p>Post-hoc analysis (Repeated–measures ANOVA P values) for longitudinal evolution of metabolic characteristics (month-0, month-3 and month-5).</p

Longitudinal evolution of metabolic characteristics (month-0, month-3 and month-5) in LIPOXmax-Réunion randomized controlled trial participants.

<p>Data are means ± SD for 103 subjects were followed-up at M0, M3 and M5). For MFO (mg/min/kg FFM), data are mean ± SD for n = 109 (subjects who participated at M0 and M5), because fat free mass DXA was measured only at M0 and at M5. M3: third month of intervention. M5: fifth month of intervention.HOMA-IR index: HOmeostasis Model Assessment estimated insulin resistance index. MFO: Maximal Fat Oxidation. FFM: Fat Free Mass. Repeated-measures ANOVA p-values represent the main effects of time (t), g (group) and the interaction effect (time *group).</p><p>Longitudinal evolution of metabolic characteristics (month-0, month-3 and month-5) in LIPOXmax-Réunion randomized controlled trial participants.</p

Baseline inclusion characteristics for LIPOXmax-Réunion randomized controlled trial participants.

<p>^† Data are medians and interquartile range.</p><p>^‡ Data are medians and interquartile range. Otherwise, data are means ± SD or percentages. CMU: universal health coverage.</p><p>HOMA-IR index: Homeostasis Model Assessment estimated insulin resistance index. p-values refer to comparison between the three groups by one-way ANOVA or Kruskal-Wallis non parametric tests (*) for quantitative variables, and by Chi2 test or Fisher exact tests (*) for qualitative variables.</p><p>Baseline inclusion characteristics for LIPOXmax-Réunion randomized controlled trial participants.</p