Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148

Supplementary material for: [https://doi.org/10.1080/14786419.2015.1135148]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2301

An Insight Into Selected Properties of Merlot Wines Obtained from Three New Clone Candidates

Covering the period 2009-2012, the quality of Merlot wines obtained from three new clone candidates (namely Nos. 022, 025 and 029, respectively; fourth phase of clonal selection) developed in the Republic of Serbia was examined. The following parameters were determined: Folin-Ciocalteu (FC) index, pH value, total acidity, volatile acids, aldehydes, esters, relative density and ash. In comparison with the standard Merlot wine (originating from mother vine), FC index (from 35.73 to 37.15) and tasting score (from 17.89 to 17.95) were higher for the wines of all three clone candidates tested. These findings are in good agreement with the observed trend for the viticultural parameters indicating better properties of the new Merlot clone candidates versus mother

An Insight Into Selected Properties of Merlot Wines Obtained from Three New Clone Candidates

Covering the period 2009-2012, the quality of Merlot wines obtained from three new clone candidates (namely Nos. 022, 025 and 029, respectively; fourth phase of clonal selection) developed in the Republic of Serbia was examined. The following parameters were determined: Folin-Ciocalteu (FC) index, pH value, total acidity, volatile acids, aldehydes, esters, relative density and ash. In comparison with the standard Merlot wine (originating from mother vine), FC index (from 35.73 to 37.15) and tasting score (from 17.89 to 17.95) were higher for the wines of all three clone candidates tested. These findings are in good agreement with the observed trend for the viticultural parameters indicating better properties of the new Merlot clone candidates versus mother

Supplementary data for the article: Vujovic, D.; Pejin, B.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. Phenolic Natural Products of the Wines Obtained from Three New Merlot Clone Candidates. Natural Product Research 2016, 30 (8), 987–990. https://doi.org/10.1080/14786419.2015.1079191

Supplementary material for: [https://doi.org/10.1080/14786419.2015.1079191]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2063

Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043

Supplementary material for: [https://doi.org/10.1016/j.scienta.2018.03.043]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2141

Supplementary material for the article: Stanimirović, B.; Djordjević, J. P.; Pejin, B.; Maletić, R.; Vujović, D.; Raičević, P.; Tešić, Ž. Impact of Clonal Selection on Cabernet Franc Grape and Wine Elemental Profiles. Scientia Horticulturae 2018, 237, 74–80. https://doi.org/10.1016/j.scienta.2018.03.043

Supplementary material for: [https://doi.org/10.1016/j.scienta.2018.03.043]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2141

Supplementary data for the article: Pejin, B.; Stanimirovic, B.; Vujovic, D.; Popovic Djordjevic, J.; Velickovic, M.; Tesevic, V. The Natural Product Content of the Selected Cabernet Franc Wine Samples Originating from Serbia: A Case Study of Phenolics. Natural Product Research 2016, 30 (15), 1762–1765. https://doi.org/10.1080/14786419.2015.1135148

Supplementary material for: [https://doi.org/10.1080/14786419.2015.1135148]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2301

alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives

The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study. All examined compounds showed higher inhibitory activity (IC50) against alpha-Gls compared to standard antidiabetic drug acarbose. The most potent was benzyl (3,4,5-trimethoxyphenyl) carbamate (12) with IC50 = 49.85 +/- 0.10 mu M. In vitro cytotoxicity of the investigated compounds was tested on three human cancer cell lines HeLa, A549 and MDA-MB-453 using MTT assay. The best antitumour activity was achieved with compound 2 (trans-5-phenethyl-1-phenylhexahydro-1H-imidazo[4,5-c] pyridin-2(3H)-one) against MDA-MB-453 human breast cancer cell line (IC50 = 83.41 +/- 1.60 mu M). Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs. The PLS model of preliminary QSAR study indicated that, in planing the future synthesis of more potent compounds, the newly designed should have the substituents capable of polar interactions with receptor sites in various positions, while avoiding the increase of their lipophilicity

Supplementary material for the article: Milojković, J. V.; Popović-Djordjević, J. B.; Pezo, L. L.; Brčeski, I. D.; Kostić, A. Ž.; Milošević, V. D.; Stojanović, M. D. Applying Multi-Criteria Analysis for Preliminary Assessment of the Properties of Alginate Immobilized Myriophyllum Spicatum in Lake Water Samples. Water research 2018, 141, 163–171. https://doi.org/10.1016/j.watres.2018.05.014

Supplementary material for: [https://doi.org/10.1016/j.watres.2018.05.014]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2186]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3029

Impact of Clonal Variability on Phenolics and Radical Scavenging Activity of Grapes and Wines: A Study on the Recently Developed Merlot and Cabernet Franc Clones (Vitis vinifera L.)

In this study, grapes and corresponding wines of Merlot /No 022, 025 and 029/ and Cabernet Franc /No 02, 010 and 012/ clones (recently developed) were evaluated regarding the total phenolic content, total anthocyanin content, and radical scavenging activity, aiming to better understand their quality and market potential. The nineteen individual polyphenols were quantified in studied grape samples using UHPLC coupled to a triple-quadrupole mass spectrometer. The mother grapes and wines were used as the relevant standards. In the grape, studied characteristics were monitored at three stages of berry development: green berry, veraison and mature berry. The mature grape of clones presented high values of total phenolics (3.81-10.89 g gallic acid equivalent kg(-1) frozen weight), anthocyanin content (359.00-1668.18 mg malvidin-3-O-glucoside kg(-1) frozen weight) and the radical scavenging activity (41.37-80.48 mmol trolox equivalent kg(-1) frozen weight) depending on the clone. Grapes and wines of Merlot No 025 and Cabernet Franc No 010 stood out with the highest values of all three parameters. Generally, the high correlation was observed between TPC and RSA values for green berries and mature grapes, as well as for wine samples. The most abundant phenolics in both Merlot and Cabernet Franc grapes were gallic acid, p-hydroxybenzoic acid, ferulic acid, catechin, epicatechin, gallocatechin gallate, catechin gallate, and rutin. Catechin, epicatechin, epigallocatechin, and catechin gallate, typical for the ripe grape of Merlot and Cabernet Franc clones, showed significant correlation with RSA values. Concentrations of individual polyphenols varied depending on the sample being studied and berry development stages. Merlot No 025 and Cabernet Franc No 010 grapes showed particularly interesting attributes for the production of high quality wines.Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3535