Innovative value creation in BRICS

The main scientific problem is the development of the cost modeling methodology of value-added accounting for the purpose of obtaining estimates of the value-added level of innovative products, which is necessary for making managerial, investment, production and other decisions at all levels of management and for monitoring the results of such decisions. The purpose of the article is to develop a methodology for accounting for the value added of innovative products, regarding the technology readiness levels for commercialization based on the analysis of problems and growth points of the national economy using the example of the BRICS international collaboration. The article revealed the features of innovative development of leading and developing countries, the need for the national economy in international collaborations to intensify innovative development, the existing problems in accounting for the value added of innovative products, the developed proprietary methodology for accounting for the value added of innovative products, regarding the technology readiness level for commercialization. The theoretical significance lies in the development of methodological foundations for accounting for the creation and distribution of value added, and the practical significance is determined by the fact that for the first time the methodology takes into account the technology readiness levels for commercialization, which gives a new approach to the practical assessment of the value-added innovation.peer-reviewe

Cluster policy in agrarian sphere in implementation of concept of economic growth

The purpose of the article is to substantiate the necessity and compile recommendations for improvement of the process of development and conduct of cluster policy in agrarian sphere during realization of the concept of economic growth by the example of modern Russia. As methodological provision, the research uses the proprietary methodology of analysis of development of agrarian sphere of economy. As a result of the use of this methodology and analysis of development of agrarian sphere of modern Russian, the authors come to the conclusion that it has a lot of negative tendencies, which causes necessity for improvement of policy in this sphere. For this, the authors offer to use clustering. The authors develop the Pyramid of optimal economic growth and the Model of realization of the concept of economic growth on the basis of conduct of cluster policy in agrarian sphere.peer-reviewe

Status of social competencies of power engineers in the context of forming the concept of an intelligent network or smart grid

The article reviews the trends which define development of power engineering in the world and in Russia. The authors emphasize that establishment of smart grids is the consequence of not only technological but also social transformations of a modern society. The authors sum up that social competencies are an integral part of professional skills of engineers who work in the field of power engineering. The authors make a hypothesis that the major (educational module) “Energy consultant for the population” might develop social competencies

Perspectives of growth of economic security by clustering of small innovation enterprises

The authors analyze the notion, sense, criteria, and indicators of evaluation of economic security and perform the evaluation of economic security of modern economic systems with the help of the offered methodology, which leads to the conclusion that one of the most successful countries are characterized by low level of economic security; therefore, there is a necessity for the search for perspectives of the increase of economic security. As a tool for increasing economic security, clustering is offered. The authors performed the structural analysis of formation of modern clusters and allowed allocating the problems of clustering which can be solved by clustering of small innovational enterprises. It is necessary that small innovational enterprises participate in the development of the program; their joint projects should at least concern, or, even better, solve their common problems (which will increase the competitiveness of cluster, as small innovational enterprises are connected by chains of value added with the same large companies); small innovational enterprises should participate – within the limits of their competencies – in the formation of the program of cluster development; there should be no artificial disunion between clusters of large enterprises and clusters of small innovational enterprises (which requires creation of common list of clusters). As a result of the research, the authors come to the conclusion that cluster is a form of increasing competitiveness within one country and in the global market, which stipulates the growth of national economic security. The highest efficiency of cluster is achieved by clustering small innovational enterprises, which stipulates the optimal level of competition in a cluster and leads to creation of innovations – which is a moving force of development of modern economy and the basis for economic security.peer-reviewe

Concessional lending as a perspective tool of development of agribusiness

The aim of the research is to find the solution to the problem of food security in non-food countries, i.e., countries in which conditions for agriculture are unfavorable. The authors offer the hypothesis that solution to this problem requires development of agribusiness, a perspective tool of which is concessional lending. In the process of the research, in order to verify this hypothesis, the authors use the methods of modeling of socio-economic systems, as well as systemic, problem, institutional, and SWOT-analysis. As a result of the research, the authors come to the conclusion that the most important problem of development of agribusiness in non-food countries is lack and low accessibility of financial resources, which is caused by high seasonality of business, its low profitability, and, correspondingly, its low investment attractiveness. Concessional lending allows solving this problem and increasing the accessibility of financial resources for agro-enterprises, which gives them a possibility for modernization of equipment and technology of production, reduction of product cost, and increase of profitability and competitiveness. The article views the peculiarities of crediting agricultural enterprises, determines the role of small enterprises of agribusiness, develops recommendations for provision of concessional lending for agro-enterprises, and describes the mechanism of development of agribusiness by means of concessional lending.peer-reviewe

The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study

The article presents the experience of 19 Russian medical institutions on the use of eribulin in combination with trastuzumab in various treatment lines of metastatic HER2+ breast cancer in routine clinical practice. Aim. The main objective of this retrospective observational study was to evaluate the efficacy and tolerability of eribulin and trastuzumab combo in HER2+ breast cancer patients pretreated with anthracyclines and taxanes. The analysis included 60 patients who received at least 2 cycles of eribulin in combination with trastuzumab. 2 patients (3.3%) received treatment as the 1st line, as the 2nd 14 (23.3%), as the 3rd 16 (26.7%), and as the 4th and more 28 (46.7%). Materials and methods. Complete response was achieved in 2 (3.3%) patients, partial response in 9 (15%), stable disease in 33 (55%), stabilization for more than 6 months in 11 (18.3%), disease progression was detected in 16 (26.7%) patients. The objective response rate was 18.3% in the whole group, the clinical benefit rate 36.7%. Results. The objective response rate in the group of the luminal subtype (ER/PR+HER2+) was 26.9%, in HER2-overexpressed subtype (ER-PR-HER2+) 8.8% and 64.7%, respectively, disease progression was recorded 2.3 times more often 35.3% versus 15.5% in the luminal subtype group. The median progression-free survival in patients with HER2+ breast cancer was 4.95 months (95% confidence interval CI 3.048.29 months), in luminal subtype 6.38 months (95% CI 3.338.54 months), in non-luminal 4.44 months (95% CI 2.47.96 months); p=0.306. The treatment was well tolerated, the spectrum of adverse events corresponded to the eribulin toxicity profile. Conclusions. The uniqueness of this study lies in the fact that on a large clinical material from the standpoint of real clinical practice, a very promising treatment regimen that is not used routinely in a number of countries has been studied, its effectiveness and satisfactory tolerance have been confirmed

Status of social competencies of power engineers in the context of forming the concept of an intelligent network or smart grid

The article reviews the trends which define development of power engineering in the world and in Russia. The authors emphasize that establishment of smart grids is the consequence of not only technological but also social transformations of a modern society. The authors sum up that social competencies are an integral part of professional skills of engineers who work in the field of power engineering. The authors make a hypothesis that the major (educational module) “Energy consultant for the population” might develop social competencies