17 research outputs found
Lajm neuroborelioza
Lyme borreliosis (LB) is a multisystemic zoonotic disease which in humans can involve the skin, joints, heart and/or nervous system. In this study a total of 11 patients with clinical manifestations have been assessed at the Institute for Occupational Health. Evaluation of the patients was done in order to determine their working capability and further professional orientation. Patients were of different gender, age, education and profession. They fulfilled at least two of the three criteria: tick infestation data (epidemiological criteria), central and/or peripheral neurological symptoms (clinical criteria) and a positive serological finding. Diagnosis was done upon classical clinical criteria: electromyeloneurography (EMNG) analysis, neurological impairments, electroencephalography (EEG), computer tomography (CT) and/or magnetic resonance imaging (MRI). IgM and IgG antibodies against B. burgdorferi were determined by commercial ELISA kits. IgM antibodies were recorded in the serum of 4 (44.4%) and IgG in 6 (66.7%) patients. Electro-myeloneurography findings of the upper and lower limbs were positive in 5 (83.3%), electroencephalography in 4 (66.6%) of the 6 observed patients and CT was positive in 4 (36.4%) of the 5 observed patients. The study has established that in patients with neuroborreliosis (NB) the capability to carry out intellectual tasks, as well as responsible duties is impaired due to poor memory. Patients suffering from peripheral neuropathies are not fit to withstand longterm walks, weight lifting and carrying or any other form of physical stress.Lajm borelioza je multisistemsko oboljenje, iz grupe zoonoza koje kod ljudi može zahvatiti kožu, zglobove, srce i/ili nervni sistem. Istraživanjem je obuhvaÄeno 11 bolesnika sa kliniÄkim manifestacijama neuroborelioze koji su ispitivani u Institutu za medicinu rada Srbije u cilju ocene radne sposobnosti i dalje profesionalne orijentacije. Ispitani su bolesnici razliÄite starosti, pola, nivoa obrazovanja i razliÄitih zanimanja koji su ispunili minimalno dva od tri kriterijuma i to: podatak o ubodu krpelja (epidemioloÅ”ki kriterijum), ispoljavanje centralnih i/ili, perifernih neuroloÅ”kih simptoma (kliniÄki kriterijum) i pozitivan seroloÅ”ki nalaz. Dijagnoza neuroborelioze je postavljena na osnovu klasiÄnih kliniÄkih kriterijuma: neuroloÅ” kih ispada, analize elektro-mioneurografije (EMNG), elektroencefalografije (EEG), kompjuterske tomografije (CT) i/ili magnetne rezonance (MRI). Ispitivanje prisustva antitela IgM i IgG klase u krvnom serumu prema B. burgdorferi vrÅ”eno je komercijalnim ELISA testom. Antitela IgM klase registrovana su u serumu Äetiri (44,4%), dok su IgG antitela registrovana kod 6 (66,7%) ispitanih pacijenata. Nalaz elektro-mioneurografije gornjih i donjih ekstremiteta je bio pozitivan kod pet (83,3%), nalaz elektroencefalografije kod Äetiri (66,6%) od Å”est ispitanih pacijenata, dok je nalaz CT bio pozitivan kod 4 (36,4%) od pet ispitanih pacijenata. Sprovedenim ispitivanjem je utvrÄeno da je kod bolesnika sa razvijenom neuroboreliozom smanjena sposobnost za bilo koju vrstu intelektualnog rada, kao i za poslove koji su povezani sa moralnom i materijalnom odgovornoÅ”Äu zbog problema sa pamÄenjem. Kod bolesnika sa perifernim neuropatijama postoji nesposobnost za poslove koji ukljuÄuju dugotrajno stajanje i hodanje, dizanje i noÅ”enje tereta, kao i bilo koju vrstu fiziÄkog rada
Destruction of diagonal and off-diagonal long range order by disorder in two-dimensional hard core boson systems
We use quantum Monte Carlo simulations to study the effect of disorder, in
the form of a disordered chemical potential, on the phase diagram of the hard
core bosonic Hubbard model in two dimensions. We find numerical evidence that
in two dimensions, no matter how weak the disorder, it will always destroy the
long range density wave order (checkerboard solid) present at half filling and
strong nearest neighbor repulsion and replace it with a bose glass phase. We
study the properties of this glassy phase including the superfluid density,
energy gaps and the full Green's function. We also study the possibility of
other localized phases at weak nearest neighbor repulsion, i.e. Anderson
localization. We find that such a phase does not truly exist: The disorder must
exceed a threshold before the bosons (at weak nn repulsion) are localized. The
phase diagram for hard core bosons with disorder cannot be obtained easily from
the soft core phase diagram discussed in the literature.Comment: 7 pages, 10 eps figures include
Ocjena radne sposobnosti pacijenta s Wilsonovom bolesti - prikaz bolesnika
Wilsonās disease (WD) is a rare, progressive autosomal recessive disorder characterised by impaired transport and excessive accumulation of copper in the liver, brain, and other tissues. The disease is diagnosed based on clinical manifestations and screening tests results. Work ability assessment of patients with WD is based on the analysis of liver, kidney, neurological, and cognitive impairments, and takes into account patientās level of education. This article presents a case with a 48-year-old male patient, who was admitted for work ability assessment due to polymorphic symptoms. The patient had been working as a salesman for 28 years. A detailed interview and examination by occupational health and other medical specialists revealed that the patient had been suffering from Wilsonās disease from the age of 13, and had now developed hepatic manifestations (compensated liver cirrhosis with portal hypertension), neurological manifestations (dystonia, dysarthria, muscle weakness, vertigo), and psychiatric manifestations (depression, insomnia, cognitive impairment) of the disease, including problems partially caused by long-lasting treatment with copper chelating agents (neurological and haematological manifestations). There were no ocular manifestations of Wilsonās disease (Kayser-Fleischer rings or sunflower cataract). The patient was assessed as having drastically diminished general work ability, dominantly due to neurological and psychiatric impairments caused by Wilsonās disease.Wilsonova je bolest rijetka, progresivna autosomno recesivna bolest karakterizirana poremeÄajem transporta bakra i posljediÄnim prekomjernim nakupljanjem bakra u jetri, mozgu i drugim tkivima i organima. Dijagnoza bolesti postavlja se na osnovi kliniÄkih manifestacija bolesti i nalaza laboratorijskih ispitivanja.
Ocjena radne sposobnosti pacijenata s Wilsonovom bolesti zasniva se na analizi postojanja oÅ”teÄenja i stupnja oÅ”teÄenja hepatiÄkih, neuroloÅ”kih, bubrežnih i kognitivnih funkcija, kao i na analizi stupnja
obrazovanja pacijenata. Prikazan je sluÄaj D. M., 48-godiÅ”njeg pacijenta, koji je primljen zbog polimorfnih tegoba na bolniÄko
ispitivanje radi ocjene radne sposobnosti. Pacijent je radio kao prodavaÄ posljednjih 28 godina. Nakon detaljne anamneze i pregleda koje su obavili specijalisti medicine rada i drugi specijalisti utvrÄeno je da pacijent boluje od Wilsonove bolesti od 13. godine života i da u ovom trenutku ima izražene hepatiÄne manifestacije (kompenzirana ciroza jetre s portalnom hipertenzijom), neuroloÅ”ke manifestacije (distonija, dizartrija, miÅ”iÄna slabost, vrtoglavica) i psihijatrijske manifestacije (depresija, nesanica, kognitivno oÅ”teÄenje) Wilsonove bolesti, kao i da su prisutne tegobe djelomiÄno uzrokovane dugotrajnom upotrebom kelatne terapije (neuroloÅ”ki i hematoloÅ”ki poremeÄaji). Nisu uoÄene karakteristiÄne oÄne promjene Wilsonove bolesti (Kayser-Fleischerov prsten, katarakta u obliku suncokreta).
Ocjenom radne sposobnosti utvrÄeno je da pacijent ima drastiÄno smanjenu radnu sposobnost pretežno zbog neuroloÅ”kih i psihiÄkih poremeÄaja u sklopu Wilsonove bolesti
Rewarming curves and derived parameters in the diagnosis of hand-arm vibration syndrome
Background: Exposure to hand-arm vibrations is a known cause of the Hand-arm vibration syndrome (HAVS), a progressive syndrome beginning with sensory loss and leading to gangrene, making timely diagnosis essential. Objectives: Assessment of the usefulness of 9 diagnostic parameters claimed as being of greatest value in the diagnosis of HAVS, and examination of the complementary diagnostic value of the curve shapes. Methods: Three groups of subjects (HAVS cases, exposed workers without irreversible changes, and controls) were examined by cold provocation followed by thermographic imaging, obtainment of rewarming curves for four preselected regions and calculation of parameters. The discriminative value of individual parameters and the discriminative power of a combination of all the parameters were assessed. Qualitative curve shape analysis was included. Results: The greatest individual discriminative ability is associated with RT (rewarming time to pre-cooling value, p lt 0.001), Tmax (maximum temperature during the 10-minute recovery, p lt 0.001), k (rewarming rate, p lt 0.012) and RD (rewarming delay, p lt 0.031). The discriminant analysis yielded one significant discriminant function (Wilks' Lambda = 0.278, chi(2)(18)=48.67, p lt 0.001, canonical R(2)=0.63). Four types of rewarming curves were identified. Conclusions: RT, Tmax, k and RD appear to be the most suitable individual parameters for group discrimination. When linearly combined, the parameters can be useful for discriminating HAVS cases from both Controls and Claimants, which constitutes the main task of an occupational health physician. Additional information is available from the qualitative assessment of the rewarming curve shape
Procjena grube i fine motoriÄke funkcije Å”ake u asimptomatiÄnih osoba izloženih vibracijama koje se prenose preko ruke i Å”ake
A frequently encountered exposure profile for hand-arm vibration in contemporary occupational setting comprises workers with a long history of intermittent exposure but without detectable signs of hand-arm vibration syndrome (HAVS). Yet, most of the published studies deal with developed HAVS cases, rarely discussing the biological processes that may be involved in degradation of manual dexterity and grip strength when it can be most beneficial - during the asymptomatic stage. In the present paper, a group of 31 male asymptomatic vibration-exposed workers (according to the Stockholm Workshop Scale) were compared against 30 male controls. They were tested using dynamometry and dexterimetry (modelling coarse and fine manual performance respectively) and cold provocation was done to detect possible differences in manual performance drop on these tests. The results showed reduced manual dexterity but no significant degradation in hand grip strength in the exposed subjects. This suggests that intermittent exposure profile and small cumulative vibration dose could only lead to a measurable deficit in manual dexterity but not hand grip strength even at non-negligible A(8) levels and long term exposures.U suvremenim uvjetima profesionalne izloženosti vibracijama koje se prenose preko ruke i Å”ake, Äesto se mogu vidjeti radnici koji su, i pored dugotrajne povremene izloženosti, i dalje bez uoÄljivih simptoma vibracijske bolesti. U veÄini dosadaÅ”njih istraživanja analizirani su ispitanici s razvijenom kliniÄkom slikom vibracijske bolesti, uz rijetka razmatranja bioloÅ”kih procesa koji mogu biti ukljuÄeni u degradaciju ruÄne spretnosti i snage stiska Å”ake, osobito u asimptomatskoj fazi, kada bi to bilo od najveÄe koristi. U ovom su istraživanju usporeÄene dvije skupine ispitanika: izložena skupina ā 31 radnik izložen lokalnim vibracijama koji prema Stockholmskoj klasifikaciji nema simptome vibracijske bolesti, i kontrolna skupina ā 30 radnika koji nisu izloženi lokalnim vibracijama. Svaki je ispitanik bio podvrgnut dinamometrijskom i deksterimetrijskom testiranju (model za grubu i finu motoriÄku funkciju Å”ake) te testu provokacije hladnoÄom radi usporedbe pada motoriÄkih funkcija Å”ake. U izloženoj skupini zabilježen je pad fine motoriÄke funkcije, ali ne i snage stiska Å”ake. Rezultati upozoravaju na mjerljiv deficit grube ali ne i fine motoriÄke funkcije Å”ake kod povremene izloženosti s malim kumulativnim dozama, Äak i kada se radi o dugotrajnoj izloženosti nezanemarivim razinama A(8). Vibracijama inducirane lezije živÄanih vlakana i/ili mehanoreceptora, koji osiguravaju senzornu povratnu vezu za signale pokreta ā Äime kontroliraju zadatke koji iziskuju precizno kretanje prstiju ā mogle bi biti odgovorne za uoÄeno smanjenje ruÄne spretnosti. Taj mehanizam, meÄutim, nije potreban za kontrolu grube sile stiska