A Color-Magnitude Diagram for a Globular Cluster In the Giant Elliptical Galaxy NGC 5128

The Hubble Space Telescope has been used to obtain WFPC2 (V,I) photometry for a large sample of stars in the outer halo of the giant elliptical NGC 5128 (d = 4 Mpc). The globular cluster N5128-C44, at the center of the Planetary Camera field, is well enough resolved to permit the construction of a color-magnitude diagram (CMD) for it which covers the brightest two magnitudes of the giant branch. The CMD is consistent with that of a normal old, moderately low-metallicity ([Fe/H] = -1.30 globular cluster, distinctly more metal-poor than most of the field halo stars at the same projected location (which average [Fe/H] ~ -0.5). This is the most distant globular cluster in which direct color-magnitude photometry has been achieved to date, and the first one belonging to a giant E galaxy.Comment: 12 pages, LaTeX, including 5 postscript figures; submitted to Astronomical Journa

Inducing strong density modulation with small energy dispersion in particle beams and the harmonic amplifier free electron laser

We present a possible method of inducing a periodic density modulation in a particle beam with little increase in the energy dispersion of the particles. The flow of particles in phase space does not obey Liouville's Theorem. The method relies upon the Kuramoto-like model of collective synchronism found in free electron generators of radiation, such as Cyclotron Resonance Masers and the Free Electron Laser. For the case of an FEL interaction, electrons initially begin to bunch and emit radiation energy with a correlated energy dispersion which is periodic with the FEL ponderomotive potential. The relative phase between potential and particles is then changed by approximately 180 degrees. The particles continue to bunch, however, there is now a correlated re-absorption of energy from the field. We show that, by repeating this relative phase change many times, a significant density modulation of the particles may be achieved with only relatively small energy dispersion. A similar method of repeated relative electron/radiation phase changes is used to demonstrate supression of the fundamental growth in a high gain FEL so that the FEL lases at the harmonic only

Rapeseed. 4. Grain quality

RAPESEED is capturing an increasing share of the world edible oilseed market. It competes with other oilseeds such as soyabeans, peanuts, sunflower and safflower seed. If Western Australia is to share in these markets it is essential that only high quality seed is produced

The 16-day variation in tidal amplitudes at Grahamstown (33.3° S, 26.5° E)

International audienceMeteor wind data at Grahamstown (33.3° S, 26.5° E) have been used to study the short-term (planetary scale) variations of the diurnal and semidiurnal tidal amplitudes at ~ 90 km altitude. Wavelet multi-resolution and spectral techniques reveal that planetary periodicities of ~ 10 and ~ 16 days dominate the wave spectrum in the ~ 2?20-day period range. The quasi-16-day oscillation is thought to be related to similar oscillations in the lower atmosphere. Also, there seems to be a link between the winter/equinox 16-day oscillation in the mean flow and that in the semidiurnal tidal amplitudes. It is thought that this is probably due to either the coupling between the normal mode-mean flow interactions and the gravity wave-tidal interactions, or to direct nonlinear interactions between planetary waves and the tide. On the other hand, a comparison of the mean flow and the diurnal tide does not show evidence of correlation. Possible reasons for this disparity are discussed briefly

The 16-day variation in the mean flow at Grahamstown (33.3° S, 26.5° E)

International audienceData from the Grahamstown (33.3° S, 26.5° E) meteor radar have been used to study the short-term variations of the mean flow at ~ 90 km altitude. The results show considerable variation characterised by a superposition of fluctuations on different planetary time scales. Wavelet multi-resolution and spectral techniques reveal that the quasi-16-day oscillation dominates the wave spectrum in the ~ 2?20-day period range. This quasi-16-day oscillation, which is thought to be related to a similar oscillation in the lower atmosphere, is found to be dominant in winter and the equinoxes. However, it is sometimes significant in summer, which could be due to cross-equatorial ducting and the selective transmissivity of gravity waves

Microstructure of nanocrystalline diamond powders studied by powder diffractometry

High resolution x-ray diffraction peaks of diamond nanosize powders of nominal sizes ranging from 5 to 250 nm were analyzed and provided information on grain structure, average size of crystallites, and concentration of dislocations. Selected samples were heat treated at 1670 K at pressures 2.0 and 5.5 GPa or had surface modified by outgassing, heat treatment at vacuum conditions, and by controlled adsorption of gases. The apparent lattice parameter method was applied to characterize the structure of a shell-core model of nanosize particles. The multiple whole profile fitting provided information on crystallite sizes and density of dislocations. Population of dislocations increased with applied pressure, while strain and interplanar distances in the surface layers decreased. Adsorption of foreign gases on the grain surface modified the structure of the surface layers but did not affect dislocations near the center of the grains

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes

Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-CoA:protein N-myristoyltransferase (NMT), an enzyme which has been validated as a drug target in human cancers, and for infectious diseases caused by fungi, viruses and protozoan parasites. We purified Caenorhabditis elegans and Brugia malayi NMTs as active recombinant proteins and carried out kinetic analyses with their essential fatty acid donor, myristoyl-CoA and peptide substrates. Biochemical and structural analyses both revealed that the nematode enzymes are canonical NMTs, sharing a high degree of conservation with protozoan NMT enzymes. Inhibitory compounds that target NMT in protozoan species inhibited the nematode NMTs with IC50 values of 2.5-10 nM, and were active against B. malayi microfilariae and adult worms at 12.5 µM and 50 µM respectively, and C. elegans (25 µM) in culture. RNA interference and gene deletion in C. elegans further showed that NMT is essential for nematode viability. The effects observed are likely due to disruption of the function of several downstream target proteins. Potential substrates of NMT in B. malayi are predicted using bioinformatic analysis. Our genetic and chemical studies highlight the importance of myristoylation in the synthesis of functional proteins in nematodes and have shown for the first time that NMT is required for viability in parasitic nematodes. These results suggest that targeting NMT could be a valid approach for the development of chemotherapeutic agents against nematode diseases including filariasis

Models of the ICM with Heating and Cooling: Explaining the Global and Structural X-ray Properties of Clusters

(Abridged) Theoretical models that include only gravitationally-driven processes fail to match the observed mean X-ray properties of clusters. As a result, there has recently been increased interest in models in which either radiative cooling or entropy injection play a central role in mediating the properties of the intracluster medium. Both sets of models give reasonable fits to the mean properties of clusters, but cooling only models result in fractions of cold baryons in excess of observationally established limits and the simplest entropy injection models do not treat the "cooling core" structure present in many clusters and cannot account for entropy profiles revealed by recent X-ray observations. We consider models that marry radiative cooling with entropy injection, and confront model predictions for the global and structural properties of massive clusters with the latest X-ray data. The models successfully and simultaneously reproduce the observed L-T and L-M relations, yield detailed entropy, surface brightness, and temperature profiles in excellent agreement with observations, and predict a cooled gas fraction that is consistent with observational constraints. The model also provides a possible explanation for the significant intrinsic scatter present in the L-T and L-M relations and provides a natural way of distinguishing between clusters classically identified as "cooling flow" clusters and dynamically relaxed "non-cooling flow" clusters. The former correspond to systems that had only mild levels (< 300 keV cm^2) of entropy injection, while the latter are identified as systems that had much higher entropy injection. This is borne out by the entropy profiles derived from Chandra and XMM-Newton.Comment: 20 pages, 15 figures, accepted for publication in the Astrophysical Journa