The 1999 Center for Simulation of Dynamic Response in Materials Annual Technical Report

Introduction: This annual report describes research accomplishments for FY 99 of the Center for Simulation of Dynamic Response of Materials. The Center is constructing a virtual shock physics facility in which the full three dimensional response of a variety of target materials can be computed for a wide range of compressive, ten- sional, and shear loadings, including those produced by detonation of energetic materials. The goals are to facilitate computation of a variety of experiments in which strong shock and detonation waves are made to impinge on targets consisting of various combinations of materials, compute the subsequent dy- namic response of the target materials, and validate these computations against experimental data

Redefining Covenant: Moving Toward Catholic Non-Supersessionism in Covenantal Considerations

Thesis advisor: Ruth LangerThe topic of covenant is perhaps the most fundamental means for humans to think about their relationship to God within a particular religious tradition. Since the time of the Second Vatican Council, the Church has gradually been reconsidering what covenant means for Catholics worldwide, especially in relation to other traditions, namely Judaism. Therefore, this paper initially aims to identify what covenant means for Jews and Catholics on an individual basis and how each tradition has historically thought about the other. Secondly, being written from a Catholic standpoint, this paper aims to redefine what covenant means for Catholicism in terms of how it addresses Judaism. Ultimately, this paper proposes a Catholic model for thinking about Judaism in a non-supersessionist manner.Thesis (BS) — Boston College, 2016.Submitted to: Boston College. College of Arts and Sciences.Discipline: Departmental Honors.Discipline: Theology

A virtual test facility for simulating the dynamic response of materials

The goal of the Caltech Center is to construct a virtual test facility (VTF): a problem solving environment for full 3D parallel simulation of the dynamic response of materials undergoing compression due to shock waves. The objective is to design a software environment that will: facilitate computation in a variety of experiments in which strong shock waves impinge on targets comprising various combinations of materials; compute the target materials' subsequent dynamic response; and validate these computations against experimental data. Successfully constructing such a facility requires modeling of the highest accuracy. We must model at atomistic scales to correctly describe the material properties of the target materials and high explosives; at intermediate (meso) scales to understand the micromechanical response of the target materials; and at continuum scales to capture properly the evolution of macroscopic effects. The article outlines such a test facility. Although it is a very simplified version of the facilities found in a shock-compression laboratory, our VTF includes all the basic features, offering a problem solving environment for validating experiments and facilitating further development of simulation capabilities

A Strategic Vision for Telemedicine and Medical Informatics in Space Flight

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63255/1/15305620050503924.pd

Effect of a Physician Uncertainty Reduction Intervention on Blood Pressure in Uncontrolled Hypertensives-A Cluster Randomized Trial

BACKGROUND: Clinical inertia, provider failure to appropriately intensify treatment, is a major contributor to uncontrolled blood pressure (BP). Some clinical inertia may result from physician uncertainty over the patient’s usual BP, adherence, or value of continuing efforts to control BP through lifestyle changes. OBJECTIVE: To test the hypothesis that providing physicians with uncertainty reduction tools, including 24-h ambulatory BP monitoring, electronic bottle cap monitoring, and lifestyle assessment and counseling, will lead to improved BP control. DESIGN: Cluster randomized trial with five intervention clinics (IC) and five usual care clinics (UCC). SETTING: Six public and 4 private primary care clinics. PARTICIPANTS: A total of 665 patients (63 percent African American) with uncontrolled hypertension (BP ≥140 mmHg/90 mmHg or ≥130/80 mmHg if diabetic). INTERVENTIONS: An order form for uncertainty reduction tools was placed in the IC participants’ charts before each visit and results fed back to the provider. OUTCOME MEASURES: Percent with controlled BP at last visit. Secondary outcome was BP changes from baseline. RESULTS: Median follow-up time was 24 months. IC physicians intensified treatment in 81% of IC patients compared to 67% in UCC (p\u3c0.001); 35.0% of IC patients and 31.9% of UCC patients achieved control at the last recorded visit (p\u3e0.05). Multi-level mixed effects longitudinal regression modeling of SBP and DBP indicated a significant, non-linear slope difference favoring IC (p time × group interaction=0.048 for SBP and p=0.001 for DBP). The model-predicted difference attributable to intervention was −2.8 mmHg for both SBP and DBP by month 24, and −6.5 mmHg for both SBP and DBP by month 36. CONCLUSIONS: The uncertainty reduction intervention did not achieve the pre-specified dichotomous outcome, but led to lower measured BP in IC patients

VIS: the visible imager for Euclid

Euclid-VIS is a large format visible imager for the ESA Euclid space mission in their Cosmic Vision program, scheduled for launch in 2019. Together with the near infrared imaging within the NISP instrument it forms the basis of the weak lensing measurements of Euclid. VIS will image in a single r+i+z band from 550-900 nm over a field of view of ~0.5 deg2. By combining 4 exposures with a total of 2240 sec, VIS will reach to V=24.5 (10{\sigma}) for sources with extent ~0.3 arcsec. The image sampling is 0.1 arcsec. VIS will provide deep imaging with a tightly controlled and stable point spread function (PSF) over a wide survey area of 15000 deg2 to measure the cosmic shear from nearly 1.5 billion galaxies to high levels of accuracy, from which the cosmological parameters will be measured. In addition, VIS will also provide a legacy imaging dataset with an unprecedented combination of spatial resolution, depth and area covering most of the extra-Galactic sky. Here we will present the results of the study carried out by the Euclid Consortium during the Euclid Definition phase.Comment: 10 pages, 6 figure

A virtual test facility for simulating the dynamic response of materials

The goal of the Caltech Center is to construct a virtual test facility (VTF): a problem solving environment for full 3D parallel simulation of the dynamic response of materials undergoing compression due to shock waves. The objective is to design a software environment that will: facilitate computation in a variety of experiments in which strong shock waves impinge on targets comprising various combinations of materials; compute the target materials' subsequent dynamic response; and validate these computations against experimental data. Successfully constructing such a facility requires modeling of the highest accuracy. We must model at atomistic scales to correctly describe the material properties of the target materials and high explosives; at intermediate (meso) scales to understand the micromechanical response of the target materials; and at continuum scales to capture properly the evolution of macroscopic effects. The article outlines such a test facility. Although it is a very simplified version of the facilities found in a shock-compression laboratory, our VTF includes all the basic features, offering a problem solving environment for validating experiments and facilitating further development of simulation capabilities

Effect of angiotensin receptor blockade on insulin sensitivity and endothelial function in abdominally obese hypertensive patients with impaired fasting glucose

AngII (angiotensin II) may contribute to cardiovascular risk in obesity via adverse effects on insulin sensitivity and endothelial function. In the present study, we examined the effects of ARB (angiotensin receptor blocker) therapy (losartan, 100 mg/day) on insulin sensitivity and endothelial function in 53 subjects with stage I hypertension, abdominal obesity and impaired fasting glucose. The study design was a randomized double-blinded parallel design placebo-controlled multi-centre trial of 8 weeks duration. We used the hyperinsulinaemic-euglycaemic clamp technique to measure insulin sensitivity (expressed as the 'M/I' value) and RH-PAT (reactive hyperaemia-peripheral arterial tonometry) to measure endothelial function. Additional measures included HOMA (homoeostasis model assessment)-B, an index of pancreatic β-cell function, and markers of inflammation [e.g. CRP (C-reactive protein)] and oxidative stress (e.g. F2-isoprostanes). ARB therapy did not alter insulin sensitivity [5.2 (2.7) pre-treatment and 4.6 (1.6) post-treatment] compared with placebo therapy [6.1 (2.9) pre-treatment and 5.3 (2.7) post-treatment; P value not significant], but did improve the HOMA-B compared with placebo therapy (P=0.05). ARB therapy also did not change endothelial function [RH-PAT, 2.15 (0.7) pre-treatment and 2.11 (0.7) post-treatment] compared with placebo therapy [RH-PAT, 1.81 (0.5) pre-treatment and 1.76 (0.7) post-treatment; P value not significant]. Markers of inflammation and oxidative stress were not significantly changed by ARB therapy. In conclusion, ARB therapy did not alter peripheral insulin sensitivity or endothelial function in this cohort of patients with essential hypertension, abdominal obesity and impaired fasting glucose, but did improve pancreatic β-cell function