Wind Variability of B Supergiants

The stellar wind of the rapidly rotating early-B supergiant, gamma Ara, is studied using time series, high-resolution IUE spectroscopy secured over approx. 6 days in 1993 March. Results are presented based on an analysis of several line species, including N(N), C(IV), Si(IV), Si(III), C(II), and Al(III). The wind of this star is grossly structured, with evidence for latitude-dependent mass loss which reflects the role of rapid rotation. Independent, co-existing time variable features are identified at low-velocity (redward of approx. -750 km/s) and at higher-speeds extending to approx. -1500 km/s. The interface between these structures is 'defined' by the appearance of a discrete absorption component which is extremely sharp (in velocity space). The central velocity of this 'Super DAC' changes only gradually, over several days, between approx. -400 and -750 km/s in most of the ions. However, its location is shifted redward by almost 400 km/s in Al(III) and C(II), indicating that the physical structure giving rise to this feature has a substantial velocity and ionization jump. Constraints on the relative ionization properties of the wind structures are discussed, together with results based on SEI line-profile-fitting methods. The overall wind activity in gamma Ara exhibits a clear ion dependence, such that low-speed features are promoted in low-ionization species, including Al(III), C(II), and Si(III). We also highlight that - in contrast to most OB stars - there are substantial differences in the epoch-to-epoch time-averaged wind profiles of gamma Ara. We interpret the results in terms of a two-component wind model for gamma Ara, with an equatorially compressed low ionization region, and a high speed, higher-ionization polar outflow. This picture is discussed in the context of the predicted bi-stability mechanism for line-driven winds in rapidly rotating early-B type stars, and the formation of compressed wind regions in rapidly rotating hot stars. The apparent absence of a substantial shift in the wind ionization mixture of gamma Ara, and the normal nature of its photospheric spectrum, suggests wind-compression as the likely dominant cause for the observed equatorial density enhancements

Gut Microbiome: Profound Implications For Diet And Disease

The gut microbiome plays an important role in human health and influences the development of chronic diseases ranging from metabolic disease to gastrointestinal disorders and colorectal cancer. Of increasing prevalence in Western societies, these conditions carry a high burden of care. Dietary patterns and environmental factors have a profound effect on shaping gut microbiota in real time. Diverse populations of intestinal bacteria mediate their beneficial effects through the fermentation of dietary fiber to produce short-chain fatty acids, endogenous signals with important roles in lipid homeostasis and reducing inflammation. Recent progress shows that an individual’s starting microbial profile is a key determinant in predicting their response to intervention with live probiotics. The gut microbiota is complex and challenging to characterize. Enterotypes have been proposed using metrics such as alpha species diversity, the ratio of Firmicutes to Bacteroidetes phyla, and the relative abundance of beneficial genera (e.g., Bifidobacterium, Akkermansia) versus facultative anaerobes (E. coli), pro-inflammatory Ruminococcus, or nonbacterial microbes. Microbiota composition and relative populations of bacterial species are linked to physiologic health along different axes. We review the role of diet quality, carbohydrate intake, fermentable FODMAPs, and prebiotic fiber in maintaining healthy gut flora. The implications are discussed for various conditions including obesity, diabetes, irritable bowel syndrome, inflammatory bowel disease, depression, and cardiovascular disease

Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics

Aim: Improvement and harmonization of European clinical pharmacology and therapeutics (CPT) education is urgently required. Because digital educational resources can be easily shared, adapted to local situations and re-used widely across a variety of educational systems, they may be ideally suited for this purpose. Methods: With a cross-sectional survey among principal CPT teachers in 279 out of 304 European medical schools, an overview and classification of digital resources was compiled. Results: Teachers from 95 (34%) medical schools in 26 of 28 EU countries responded, 66 (70%) of whom used digital educational resources in their CPT curriculum. A total of 89 of such resources were described in detail, including e-learning (24%), simulators to teach pharmacokinetics and/or pharmacodynamics (10%), virtual patients (8%), and serious games (5%). Together, these resources covered 235 knowledge-based learning objectives, 88 skills, and 13 attitudes. Only one third (27) of the resources were in-part or totally free and only two were licensed open educational resources (free to use, distribute and adapt). A narrative overview of the largest, free and most novel resources is given. Conclusion: Digital educational resources, ranging from e-learning to virtual patients and games, are widely used for CPT education in EU medical schools. Learning objectives are based largely on knowledge rather than skills or attitudes. This may be improved by including more real-life clinical case scenarios. Moreover, the majority of resources are neither free nor open. Therefore, with a view to harmonizing international CPT education, more needs to be learned about why CPT teachers are not currently sharing their educational materials

EurOP2E – the European Open Platform for Prescribing Education, a consensus study among clinical pharmacology and therapeutics teachers

Purpose Sharing and developing digital educational resources and open educational resources has been proposed as a way to harmonize and improve clinical pharmacology and therapeutics (CPT) education in European medical schools. Previous research, however, has shown that there are barriers to the adoption and implementation of open educational resources. The aim of this study was to determine perceived opportunities and barriers to the use and creation of open educational resources among European CPT teachers and possible solutions for these barriers. Methods CPT teachers of British and EU medical schools completed an online survey. Opportunities and challenges were identified by thematic analyses and subsequently discussed in an international consensus meeting. Results Data from 99 CPT teachers from 95 medical schools were analysed. Thirty teachers (30.3%) shared or collaboratively produced digital educational resources. All teachers foresaw opportunities in the more active use of open educational resources, including improving the quality of their teaching. The challenges reported were language barriers, local differences, lack of time, technological issues, difficulties with quality management, and copyright restrictions. Practical solutions for these challenges were discussed and include a peer review system, clear indexing, and use of copyright licenses that permit adaptation of resources. Conclusion Key challenges to making greater use of CPT open educational resources are a limited applicability of such resources due to language and local differences and quality concerns. These challenges may be resolved by relatively simple measures, such as allowing adaptation and translation of resources and a peer review system