8 research outputs found
Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy
Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in nâ=â28 TCM patients. Patients with MRI within 5âdays from admission ("early TCM") showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that "early TCM" LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity
L'esilio nella storia del Novecento: modelli interpretativi, spazi e comunitĂ di saperi
Il volume descrive gli anni dell'esilio americano di Bruno Zevi e il suo successivo impegno nella guerra fredda culturale in Italia
Inflow artifact reduction using an adaptive flipâangle navigator restore pulse for late gadolinium enhancement of the left atrium
Threeâdimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural âFingerprintsâ of HeartâSpecific Atrial Fibrillation Drivers in Human Heart Ex Vivo
Searching for the Key to Foreseeing Left Atrial Fibrosis in Atrial Fibrillation: Could This Be Simple and Reliable with MRI?
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Segmenting atrial fibrosis from late gadolinium-enhanced cardiac MRI by deep-learned features with stacked sparse auto-encoders
The late gadolinium-enhanced (LGE) MRI technique is a well-validated method for fibrosis detection in the myocardium. With this technique, the altered wash-in and wash-out contrast agent kinetics in fibrotic and healthy myocardium results in scar tissue being seen with high or enhanced signal relative to normal tissue which is ânulledâ. Recently, great progress on LGE MRI has resulted in improved visualization of fibrosis in the left atrium (LA). This provides valuable information for treatment planning, image-based procedure guidance and clinical management in patients with atrial fibrillation (AF). Nevertheless, precise and objective atrial fibrosis segmentation (AFS) is required for accurate assessment of AF patients using LGE MRI. This is a very challenging task, not only because of the limited quality and resolution of the LGE MRI images acquired in AF but also due to the thinner wall and unpredictable morphology of the LA. Accurate and reliable segmentation of the anatomical structure of the LA myocardium is a prerequisite for accurate AFS. Most current studies rely on manual segmentation of the anatomical structures, which is very labor-intensive and subject to inter- and intra-observer variability. The subsequent AFS is normally based on unsupervised learning methods, e.g., using thresholding, histogram analysis, clustering and graph-cut based approaches, which have variable accuracy. In this study, we present a fully-automated multi-atlas propagation based whole heart segmentation method to derive the anatomical structure of the LA myocardium and pulmonary veins. This is followed by a supervised deep learning method for AFS. Twenty clinical LGE MRI scans from longstanding persistent AF patients were entered into this study retrospectively. We have demonstrated that our fully automatic method can achieve accurate and reliable AFS compared to manual delineated ground truth