12 research outputs found
Physiological levels of estradiol limit murine osteoarthritis progression
- Author
- Publication venue
- 'Bioscientifica'
- Publication date
- 29/11/2022
- Field of study
Among patients with knee osteoarthritis (OA), postmenopausal women are overrepresented. The purpose of this study was to determine whether deficiency of female sex steroids affects OA progression and to evaluate the protective effect of treatment with a physiological dose of 17β-estradiol (E2) on OA progression using a murine model. Ovariectomy (OVX) of female mice was used to mimic a postmenopausal state. OVX or sham-operated mice underwent surgery for destabilization of the medial meniscus (DMM) to induce OA. E2 was administered in a pulsed manner for 2 and 8 weeks. OVX of OA mice did not influence the cartilage phenotype or synovial thickness, while both cortical and trabecular subchondral bone mineral density (BMD) decreased after OVX compared with sham-operated mice at 8 weeks post-DMM surgery. Additionally, OVX mice displayed decreased motor activity, reduced threshold of pain sensitivity, and increased number of T cells in the inguinal lymph nodes compared to sham-operated mice 2 weeks after OA induction. Eight weeks of treatment with E2 prevented cartilage damage and thickening of the synovium in OVX OA mice. The motor activity was improved after E2 replacement at the 2 weeks time point, which was also associated with lower pain sensitivity in the OA paw. E2 treatment protected against OVX-induced loss of subchondral trabecular bone. The number of T cells in the inguinal lymph nodes was reduced by E2 treatment after 8 weeks. This study demonstrates that treatment with a physiological dose of E2 exerts a protective role by reducing OA symptoms. © 2022 The authors Published by Bioscientifica Ltd.</p
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
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- AKI Research Group
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- Kang Y
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- Kappler F
- Kara A
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- Karanjia N
- Karbing DS
- Karsten E
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- Kashiya S
- Kashyap R
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- Katabami K
- Katabami K
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- Kim JW
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- Kleinpell R
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- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
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- Kodate A
- Kodate A
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- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
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- Kou PS
- Kouatchet A
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- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
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- Ku NS
- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
- Kyle UG
- Labaune MA
- Labra C
- Lacerda P
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- Lafuente E
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- Lagos R
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- Leitao AL
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- Leonard H
- Leone M
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- Lerma FA
- Lesmes SP
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- Lesmes SP
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- Lheureux O
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- Liao X
- Lichtenstein D
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- Lin KC
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- Lin PH
- Lin SC
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- Lischinsky A
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- Liu CP
- Liu CP
- Liu CP
- Liu CP
- Liu D
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- Llorente B
- Llorente MÁ
- Lobato MS
- Lobo-Civico A
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- Lombardo MD
- Londoño JG
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- Lopez R
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- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
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- Lotay R
- Loudet CI
- Louf-Durier A
- Louf-Durier A
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- Lukaszewicz AC
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- MacKay A
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- Mackey G
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- Macrì M
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- Maekawa K
- Maekawa K
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- Maghsoudi B
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- Maistry N
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- Martín-Loeches I
- Martínez F
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- Mergulhão PJ
- Merino-Vega D
- Messenger D
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- Mezidi M
- Michel L
- Midwinter MJ
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- Miguelena PR
- Mihara Y
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- Olaechea P
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- Philips BJ
- Phongpagdi P
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- Picoita F
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- Radu V
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- Rodríguez FG
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- Rood PJ
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- Rossini P
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- Spronk PE
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- Stubbs C
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- Stümpfle R
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- Su L
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- Suchomel P
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- Suh GJ
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- Sánchez MJ
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- Sánchez MJ
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- Sánchez PC
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- Tabei SH
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- Taccone FS
- Taccone FS
- Taccone FS
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- Tang LK
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- Tapponnier R
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- Tena SA
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- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
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- Tomic I
- Tominaga N
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- Tonetti T
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- van der Hoeven JG
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- Vanhuyse F
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- WIND study group
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Investigating the biology of atypical teratoid/rhabdoid tumors by whole genome CRISPR/CAS9 screening
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Chronic, Active Inflammation in Patients with Failed Total Knee Replacements Undergoing Revision Surgery
- Publication venue
- John Wiley & Sons, Inc.
- Publication date
- Field of study
AT-18INVESTIGATING THE BIOLOGY OF ATYPICAL TERATOID/RHABDOID TUMORS BY WHOLE GENOME CRISPR/CAS9 SCREENING
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
A PHYSIOLOGICAL DOSE OF ESTRADIOL IN A MURINE OSTEOARTHRITIS MODEL PARTIALLY RESCUES THE PHENOTYPE OF THE HEALTHY JOINT
- Author
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2
- Author
- Publication venue
- Elsevier Inc.
- Publication date
- Field of study
Integrated pathway analysis of rhabdoid tumor subtypes identifies key SMARCB1-dependencies and therapeutic opportunities
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
AT-20INTEGRATED PATHWAY ANALYSIS OF RHABDOID TUMOR SUBTYPES IDENTIFIES KEY SMARCB1-DEPENDENCIES AND THERAPEUTIC OPPORTUNITIES
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis
- Author
- Publication venue
- 'American Society for Clinical Investigation'
- Publication date
- Field of study