How To Live With Your Carpet

A carpet on the floor brings beauty and comfort to a home. But it also brings unhappiness is we have to worry all the time about keeping it spotless. Here are some keys to better care and enjoyment of carpeting

Cricket Island Foundation: A Case Study of a Small Foundation’s Impact Assessment

In 2015, the Cricket Island Foundation conducted a multimethod assessment of its grantmaking portfolio to examine its impact and inform future decision-making and strategy. The foundation, which supports youth-led social change using a cohort-based model, focuses on emerging and medium-sized organizations and provides capacity-building supports to help organizations achieve greater organizational sustainability. The assessment focused on two of the foundation\u27s three cohorts and found positive trends in five key areas of desired impact: organizational capacity, youth leadership, nonprofit executive leadership, grantee collaboration and learning, and funder policy and practice. The assessment also identified areas for improvement to strengthen future impact, and prompted a review and update of the foundation\u27s ongoing protocols for tracking its progress. This article will explore what was learned from a model of providing long-term capacity-building investments to grassroots organizations, and discuss the ways in which even small foundations can implement meaningful assessment protocols while minimizing data-collection burdens on grantee partners

The Effect of Nutrition Education on the Dietary Intake of College Students

According to Guthrie, nutrition professionals are especially concerned about the food habits of adolescents. Dietary inadequacies are higher during adolescence than at any other stage of the life cycle. Deficiencies in this age range can have fat reaching effects, especially for females. Female adolescent nutritive needs are surpassed only by those during pregnancy and lactation. The adolescent who becomes pregnant before growth is complete is of particular concern. If nutritive intake is inadequate before conception the adolescent and her unborn child are at high risk. Another nutritionally related concern in adolescence is the increased incidence of eating disorders such as anorexia nervosa (self-imposed starvation) and bulimia (binge-purge syndrome), especially among adolescent girls. These illnesses involve obsessive fear of weight gain and can have serious health consequences, even death. Education appears to have little impact on changing adolescent’s food habits. The effects of long term malnutrition on health is of little concern to the adolescent. Motivation appears to be the important factor for change in eating habits. Wenck et al. continue by stating that the highest time of motivation for learning about nutrition is not when one is young and living at home, but rather when faced with the actual problem of providing food for oneself or one’s family. Many studies have been done on nutritive intake and dietary practices of younger adolescents in junior and senior high schools. There is less information available on older adolescents, particularly concerning nutrition education. Is it possible that a group of older adolescents, college students, would be motivated to learn about ·nutrition and to apply this knowledge to their own eating habits more than the younger adolescents? Most college students are away from home for the first time and are completely responsible for their food choices. College students are usually more mature and may be less influenced by their peer group than younger adolescents. Would a career interest in home economics, a professional field encompassing the subject area of nutrition, affect food choices and nutrient intake of college students? The relationship seems logical and some of Alexander\u27s findings give support to this contention. Alexander found that college home economics students who had nutrition in their curriculum scored significantly higher than non-home economics students on a nutrition knowledge test. The purpose of the study was to determine the effects of nutrition education on the dietary intake of college students. Specific questions to be answered were: 1) What is the dietary intake of college students? 2) Does nutrition education intervention have an effect on dietary intake of college students? 3) Does change in dietary intake relate to background characteristics of college students

Dissection: A Fate worse than Death?

The teaching of Anatomy in medical schools has significantly declined, and doubts have been raised over whether or not doctors of today are fully equipped with anatomical knowledge required to practice safely. The history of anatomy teaching has changed enormously over centuries, and donating your body to medical science after death is very different today, compared with the body snatching and exhumations of the 18th and 19th centuries. With stories of public outcry, theft and outright murder, the history of anatomical education is a fascinating one. History has made an abundance of significant anatomical discoveries, is it not fundamental that medical students today are aware of the great lengths that our peers went to in order to obtain such pioneering discoveries

Healthier choices in an Australian health service : a pre-post audit of an intervention to improve the nutritional value of foods and drinks in vending machines and food outlets

Background: Vending machines and shops located within health care facilities are a source of food and drinks for staff, visitors and outpatients and they have the potential to promote healthy food and drink choices. This paper describes perceptions of parents and managers of health-service located food outlets towards the availability and labelling of healthier food options and the food and drinks offered for sale in health care facilities in Australia. It also describes the impact of an intervention to improve availability and labelling of healthier foods and drinks for sale. Methods: Parents (n = 168) and food outlet managers (n = 17) were surveyed. Food and drinks for sale in health-service operated food outlets (n = 5) and vending machines (n = 90) in health care facilities in the Hunter New England region of NSW were audited pre (2007) and post (2010/11) the introduction of policy and associated support to increase the availability of healthier choices. A traffic light system was used to classify foods from least (red) to most healthy choices (green). Results: Almost all (95%) parents and most (65%) food outlet managers thought food outlets on health service sites should have signs clearly showing healthy choices. Parents (90%) also thought all food outlets on health service sites should provide mostly healthy items compared to 47% of managers. The proportion of healthier beverage slots in vending machines increased from 29% to 51% at follow-up and the proportion of machines that labelled healthier drinks increased from 0 to 26%. No outlets labelled healthier items at baseline compared to 4 out of 5 after the intervention. No changes were observed in the availability or labelling of healthier food in vending machines or the availability of healthier food or drinks in food outlets. Conclusions: Baseline availability and labelling of healthier food and beverage choices for sale in health care facilities was poor in spite of the support of parents and outlet managers for such initiatives. The intervention encouraged improvements in the availability and labelling of healthier drinks but not foods in vending machines

Between a rock and a hard place? Navigating domestic and international expectations on German foreign policy

This article takes stock of German foreign policy during Angela Merkel's third term in office (2013–17). It argues that the longer-term significance of Germany's foreign policy during this period is twofold. First, the Merkel government was confronted with multiple European and international crises which worked as a magnifying glass for the growing international expectations on Germany to become more actively engaged on the international stage. Second, the tenure of the Grand Coalition saw a significant shift in the German domestic foreign policy discourse that was marked by a concerted effort of leading decision-makers to make the case for Germany to accept greater international responsibilities. This emerging consensus among foreign policy elites expresses a changed self-conception of German foreign policy which, however, continues to be viewed with scepticism in the broader public. Informed by such a broad two-level perspective that focuses on the interplay between international and domestic expectations on German foreign policy, the article explores the record of the Grand Coalition in the main international crises it had to engage with. It suggests that the Merkel government was better able to live up to its own aspirations in two-level contexts which left it with greater domestic room for manoeuvre

Validation of the prognostic performance of Breast Cancer Index (BCI) in hormone receptor-positive (HR+) postmenopausal breast cancer patients in the TEAM trial

Purpose: Early-stage HR+ breast cancer patients face a prolonged risk of recurrence even after adjuvant endocrine therapy. The Breast Cancer Index (BCI) is significantly prognostic for overall (0-10 years) and late (5-10 years) distant recurrence risk (DR) in N0 and N1 patients. Here, BCI prognostic performance was evaluated in HR+ postmenopausal women from the TEAM trial.Experimental Design: 3544 patients were included in the analysis (N=1519 N0, N=2025 N+). BCI risk groups were calculated using pre-specified cut-points. Kaplan-Meier analyses and logranktests were used to assess the prognostic significance of BCI risk groups based on DR. Hazard ratios (HR) and confidence intervals (CI) were calculated using Cox models with and without clinical covariates.Results: For overall 10-year DR, BCI was significantly prognostic in N0 (N=1196) and N1 (N=1234) patients who did not receive prior chemotherapy (p<0.001). In patients who were DRfree for 5 years, 10-year late DR rates for low- and high-risk groups were 5.4% and 9.3% (N0 cohort, N=1285) and 4.8% and 12.2% (N1 cohort, N=1625) with multivariate HRs of 2.25 (95% CI: 1.30-3.88; p=0.004) and 2.67 (95% CI: 1.53-4.63; p=<0.001), respectively. Late DR performance was substantially improved using previously optimized cut-points, identifying BCIlow-risk groups with even lower 10-year late DR rates of 3.8% and 2.7% in N0 and N1 patients, respectively.Conclusions: The TEAM trial represents the largest prognostic validation study for BCI to date and provides a more representative assessment of late DR risk to guide individualized treatment decision-making for HR+ early-stage breast cancer patients

Viral CpG Deficiency Provides No Evidence That Dogs Were Intermediate Hosts for SARS-CoV-2.

Due to the scope and impact of the COVID-19 pandemic there exists a strong desire to understand where the SARS-CoV-2 virus came from and how it jumped species boundaries to humans. Molecular evolutionary analyses can trace viral origins by establishing relatedness and divergence times of viruses and identifying past selective pressures. However, we must uphold rigorous standards of inference and interpretation on this topic because of the ramifications of being wrong. Here, we dispute the conclusions of Xia (2020. Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense. Mol Biol Evol. doi:10.1093/molbev/masa095) that dogs are a likely intermediate host of a SARS-CoV-2 ancestor. We highlight major flaws in Xia's inference process and his analysis of CpG deficiencies, and conclude that there is no direct evidence for the role of dogs as intermediate hosts. Bats and pangolins currently have the greatest support as ancestral hosts of SARS-CoV-2, with the strong caveat that sampling of wildlife species for coronaviruses has been limited

Visceral adipose tissue immune homeostasis is regulated by the crosstalk between adipocytes and dendritic cell subsets

Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/β-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARγ pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail β-catenin and PPARγ activation, contributing to VAT inflammation