Ciclagem de nutrientes em cultivo de terceira soca de cana-de-açúcar.

Resumo: O objetivo do trabalho foi avaliar a liberação de macronutrientes em função de níveis de palhada mantida sobre o solo, na terceira soca de cana-de-açúcar, e sua contribuição para ciclos posteriores. O ensaio foi instalado em Araras ?SP, safra 2011-2012 (variedade RB-845210). Os tratamentos foram os níveis de palhada 25% - 50% - 75% - 100% (2,8 - 5,7 - 8,5 -11,3 t ha-1 em base seca) dispostos em blocos ao acaso, 4 repetições. Foi utilizado o método dos ?litter bags? para avaliar a decomposição da biomassa e sua respectiva ciclagem de nutrientes. Determinou-se as concentrações (g kg-1) de N, P, K, Ca, Mg e S e as quantidades (kg ha-1) liberadas após um ciclo de cultivo. Utilizou-se a análise de variância e regressão. As concentrações de N, P, Ca e S diferiram com níveis de palhada; já o K e Mg não responderam aos tratamentos. O modelo linear melhor se ajustou para as concentrações do N, P, K e Ca, com exceção do Mg e S. Houve maior liberação de nutrientes nos maiores níveis de palhada, porém esta diferença foi atribuída ao aumento da massa entre os tratamentos. Os elementos Ca, K e N, respectivamente, foram os mais liberados, independente dos tratamentos. Conclui-se que variações na quantidade de palhada deixadas sobre o solo apresentam comportamentos diferentes de mineralização de nutrientes durante um ciclo de cultivo da cana-de-açúcar. Há maior liberação de nutrientes nos maiores níveis de palhada, sendo os elementos Ca, K e N, respectivamente, os mais liberados

Introducing Interactions in Multi-Objective Optimization of Software Architectures

Software architecture optimization aims to enhance non-functional attributes like performance and reliability while meeting functional requirements. Multi-objective optimization employs metaheuristic search techniques, such as genetic algorithms, to explore feasible architectural changes and propose alternatives to designers. However, the resource-intensive process may not always align with practical constraints. This study investigates the impact of designer interactions on multi-objective software architecture optimization. Designers can intervene at intermediate points in the fully automated optimization process, making choices that guide exploration towards more desirable solutions. We compare this interactive approach with the fully automated optimization process, which serves as the baseline. The findings demonstrate that designer interactions lead to a more focused solution space, resulting in improved architectural quality. By directing the search towards regions of interest, the interaction uncovers architectures that remain unexplored in the fully automated process

Early and long-term results of pectoralis muscle flap reconstruction versus sternal rewiring following failed sternal closure

Objectives: The aim of the study was to compare early and long-term results of pectoralis muscle flap reconstruction with those of sternal rewiring following failed sternal closure. Primary outcomes of the study were survival and failure rate. Respiratory function, chronic pain and quality of life were also evaluated. Methods: In a propensity-score matching analysis, of 94 patients who underwent sternal reconstruction, 40 were selected; 20 underwent sternal reconstruction with bilateral pectoralis muscle flaps (Group 1) and 20 underwent sternal rewiring (Group 2). Survival and failure rates were evaluated by in-hospital records and at follow-up. Respiratory function measures, including vital capacity (VC), were evaluated both by spirometry and computed tomography (CT) volumetry. Chronic pain was evaluated by the visual analogue pain scale. Results: At 85 ± 24 months of follow-up, survival and procedure failure were 95 and 90% in Group 1 and 60 and 55% in Group 2, respectively (P < 0.01, for both comparisons). Based on CT-scan volumetry, in Group 1, severe non-union and hemisternal paradoxical movement occurred less frequently (2 vs 7, P = 0.01). At spirometry assessment, postoperative VC was greater in Group 1 (3220 ± 290 vs 3070 ± 290 ml, P = 0.04). The same trend was detected by CT-scan in-expiratory measures (4034 ± 1800 vs 3182 ± 862 mm3, P < 0.05). Correspondingly, in Group 1, less patients presented in NYHA Class III (P < 0.05), and both chronic persistent pain score and physical health quality-of-life score were significantly better in the same group. Conclusions: In our study, muscle flap reconstruction guaranteed better early and late-term results as shown by lower rates of mortality, procedure failure and hemisternum stability. Moreover, Group 1 patients had greater postoperative VC, lower NYHA class and better quality of life. These results suggest that, in patients with multiple bone fracture, the rewiring approach does not promote physiological bone consolidation, whereas the muscle flap reconstruction can assure more physiological ventilatory dynamics.© The Author 2013. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved

Early and long-term results of pectoralis muscle flap reconstruction vs sternal rewiring following failed sternal closure.

OBJECTIVES: The aim of the study was to compare early and long-term results of pectoralis muscle flap reconstruction with those of sternal rewiring following failed sternal closure. Primary outcomes of the study were survival and failure rate. Respiratory function, chronic pain and quality of life were also evaluated. METHODS: In a propensity-score matching analysis, of 94 patients who underwent sternal reconstruction, 40 were selected; 20 underwent sternal reconstruction with bilateral pectoralis muscle flaps (Group 1) and 20 underwent sternal rewiring (Group 2). Survival and failure rates were evaluated by in-hospital records and at follow-up. Respiratory function measures, including vital capacity (VC), were evaluated both by spirometry and computed tomography (CT) volumetry. Chronic pain was evaluated by the visual analogue pain scale. RESULTS: At 85 ± 24 months of follow-up, survival and procedure failure were 95 and 90% in Group 1 and 60 and 55% in Group 2, respectively (P < 0.01, for both comparisons). Based on CT-scan volumetry, in Group 1, severe non-union and hemisternal paradoxical movement occurred less frequently (2 vs 7, P = 0.01). At spirometry assessment, postoperative VC was greater in Group 1 (3220 ± 290 vs 3070 ± 290 ml, P = 0.04). The same trend was detected by CT-scan in-expiratory measures (4034 ± 1800 vs 3182 ± 862 mm3, P < 0.05). Correspondingly, in Group 1, less patients presented in NYHA Class III (P < 0.05), and both chronic persistent pain score and physical health quality-of-life score were significantly better in the same group. CONCLUSIONS: In our study, muscle flap reconstruction guaranteed better early and late-term results as shown by lower rates of mortality, procedure failure and hemisternum stability. Moreover, Group 1 patients had greater postoperative VC, lower NYHA class and better quality of life. These results suggest that, in patients with multiple bone fracture, the rewiring approach does not promote physiological bone consolidation, whereas the muscle flap reconstruction can assure more physiological ventilatory dynamics

Síntesis de solketal empleando bentonitas modificadas como catalizador

En este trabajo se estudia la acetalización de glicerol con acetona para obtener solketal, compuesto de interés en la aditivación de combustibles. Se prepararon catalizadores basados en bentonitas, modificadas por un tratamiento de acidificación. Para ello, se trataron las arcillas con ácido nítrico de distinta concentración (0,01-0,5 M)

Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux

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Acetalización de glicerol: un estudio de sólidos mesoporosos en la síntesis de solketal

El objetivo de este trabajo es estudiar la transformación de materia prima proveniente de la biomasa en acetales cíclicos como el solketal, (2,2-dimetil-1,3-dioxolano-4-metanol) por reacción de condensación de glicerol con acetona utilizando catalizadores ácidos

Neuronal Na+ Channels Are Integral Components of Pro-Arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation

SummaryAlthough triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the subcellular/molecular arrhythmogenic trigger(s) is unclear. Here, we systematically investigated the subcellular and molecular consequences of β-AR stimulation in the promotion of catecholamine-induced cardiac arrhythmias. Using mouse models of cardiac calsequestrin-associated CPVT, we demonstrate that a subpopulation of Na+ channels, mainly the neuronal Na+ channels (nNav), colocalize with ryanodine receptor 2 (RyR2) and Na+/Ca2+ exchanger (NCX) and are a part of the β-AR-mediated arrhythmogenic process. Specifically, augmented Na+ entry via nNav in the settings of genetic defects within the RyR2 complex and enhanced sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA)-mediated SR Ca2+ refill is both an essential and a necessary factor for arrhythmogenesis. Furthermore, we show that augmentation of Na+ entry involves β-AR–mediated activation of CAMKII, subsequently leading to nNav augmentation. Importantly, selective pharmacological inhibition as well as silencing of Nav1.6 inhibit myocyte arrhythmic potential and prevent arrhythmias in vivo. Taken together, these data suggest that the arrhythmogenic alteration in Na+/Ca2+ handling evidenced ruing β-AR stimulation results, at least in part, from enhanced Na+ influx through nNav. Therefore, selective inhibition of these channels and of Nav1.6 in particular can serve as a potential antiarrhythmic therapy