Potentially toxic elements speciation in bottom ashes from a municipal solid waste incinerator: A combined SEM-EDS, µ-XRF and µ-XANES study

Bottom Ashes from Municipal Solid Waste Incinerators and Waste to Energy plants represent an interesting source of secondary raw materials for many applications, like urban mining and inclusion in concrete, and road pavement. However, Bottom Ashes may contain potentially toxic elements, whose actual toxicity depends essentially on their oxidation state and mineralogical environment. For this reason, a representative sample of bottom ashes from Parma Waste to Energy plant has been selected to investigate the chemical speciation of Cr, Ni, Pb, Co, Zn and Cu by means of complementary techniques: Scanning Electron Microscopy with Energy Dispersive X-Ray Spectroscopy (SEM-EDS), micro X-Ray Fluorescence (µ-XRF) mapping and X-Ray Absorption Near Edge Structure (XANES) measurements by synchrotron radiation. This multi-technique approach allowed to obtain a general image of the mineralogical and chemical environment in which these elements are found. SEM-EDS analyses show the presence of Zn and Pb both in minerals and in glass matrix. Cr has been detected in the form of oxide and in spinel structure (chromite) whereas Co and Cu are found as alloy or metal inclusions. µ-XRF mapping reveals that Cu, Ni and Cr are generally associated to Na, K and Si suggesting their presence in glass matrix. XANES investigations exhibit that Cu has a variable oxidation state that suggesting its presence in the form of oxide, hydroxide, acetate and metal. Zn is mainly found as +II and in a number of different phases (including Zn-carbonates, in agreement with SEM-EDS data). Cr has been found only as +III, with XANES features resembling those of chromite, whereas as +VI was never identified. Ni and Co were found either as metal form and oxides. Pb spectra show a good match with oxides

Deposit shape control for local repair and welding by cold spray

Cold spray (CS) has proven to be a versatile deposition method with considerable capabilities in multiple fields including coating, additive manufacturing, and repair. Despite the significant progress in new applications of cold spray, there are still several challenges associated with controlling the shape of cold spray deposits that consequently affect their range of application and functionality. In this study, we discuss and demonstrate a new application of CS to connect adjoining edges along with repair local damages, focusing on deposit shape prediction. To do so, we start by proposing a numerical model that can predict the CS deposit geometry, by providing specific input parameters for a given set of particle and substrate properties, substrate geometry and nozzle position. Then we employ this numerical method to design the toolpath required for filling the artificial local damages and/or the welding grooves with controlled geometries. Through comparing the predictions with the shape of experimentally obtained depositions, we propose some corrections for the model. In both local repair and welding cases, the experimental results show a great resemblance to the predicted deposit profile and after applying the corrective measures, to the deposit height

Comprehensive Analysis of Two H13-Type Starting Materials Used for Laser Cladding and Aerosol Particles Formed in This Process

Laser cladding with H13 steel powders was performed and the related material transformations were studied for the particles emitted during this process. Fractions of various sizes of the aerosol particles formed during the laser cladding were collected on a cascade impactor, while the electromobility and the aerodynamic size of the particles were measured using a scanning mobility particle spectrometer and an aerodynamic particle sizer, respectively. The aerosol particles deposited onto the impactor plates were analyzed using scanning electron microscopy–energy-dispersive X-ray spectroscopy, as well as total-reflection X-ray fluorescence and X-ray absorption near-edge structure spectroscopy. Both the concentration and mean oxidation state of the major components were correlated with the aerosol particle size. The ultrafine aerosol particles (with a diameter less than about 100 nm) were predominantly oxidized and formed as the result of an evaporation–oxidation–condensation process sequence. The larger particles (>200 nm in geometric diameter) were primarily the residues of the original metal powder and exhibited a composition change as compared to the as-received metal powder. Correlations between the changes in the concentration ratio of the components were detected and explained

Near infrared spectroscopy (NIRS) as a new non-invasive tool to detect oxidative skeletal muscle impairment in children survived to acute lymphoblastic leukaemia

BACKGROUND: Separating out the effects of cancer and treatment between central and peripheral components of the O2 delivery chain should be of interest to clinicians for longitudinal evaluation of potential functional impairment in order to set appropriate individually tailored training/rehabilitation programmes. We propose a non-invasive method (NIRS, near infrared spectroscopy) to be used in routine clinical practice to evaluate a potential impairment of skeletal muscle oxidative capacity during exercise in children previously diagnosed with acute lymphoblastic leukaemia (ALL). The purpose of this study was to evaluate the capacity of skeletal muscle to extract O2 in 10 children diagnosed with ALL, 1 year after the end of malignancy treatment, compared to a control group matched for gender and age (mean±SD = 7.8±1.5 and 7.3±1.4 years, respectively). METHODS AND FINDINGS: Participants underwent an incremental exercise test on a treadmill until exhaustion. Oxygen uptake ([Formula: see text]), heart rate (HR), and tissue oxygenation status (Δ[HHb]) of the vastus lateralis muscle evaluated by NIRS, were measured. The results showed that, in children with ALL, a significant linear regression was found by plotting [Formula: see text] vs Δ[HHb] both measured at peak of exercise. In children with ALL, the slope of the HR vs [Formula: see text] linear response (during sub-maximal and peak work rates) was negatively correlated with the peak value of Δ[HHb]. CONCLUSIONS: The present study proves that the NIRS technique allows us to identify large inter-individual differences in levels of impairment in muscle O2 extraction in children with ALL. The outcome of these findings is variable and may reflect either muscle atrophy due to lack of use or, in the most severe cases, an undiagnosed myopathy

Impact of Hanging Motionless in Harness on Respiratory and Blood Pressure Reflex Modulation in Mountain Climbers

Harness hang syncope (HHS) is a risk that specifically affects safety of harness users in mountain climbing. Aims: To evaluate individual patterns of breathing resulting from deranged cardiovascular reflexes triggering a syncopal event when a mismatch between cerebral O2 demand and supply is present. Results: Forty healthy participants [aged 39.1 (8.2) years] were enrolled in a motionless suspension test while hanging in harness. Respiratory gas exchange values were analyzed to assess the pattern of breathing (EpInWel, respiratory elastic power) and cardiovascular parameters were monitored (BP, blood pressure). Four participants experienced HHS after 30.0 (7.6) minutes, with an early manifestation of loss of control of both a sustainable EpInWel and BP, starting after 10-12 minutes. Among the other participants, two different reactions were observed during suspension: (1) group G1 tolerated 32.7 (11.4) minutes of suspension by a favorable adaptation of the EpInWel and BP parameters and (2) group G2 showed significantly shorter time of suspension 24.0 (10.4) minutes with unfavorable increase in EpInWel and BP. Conclusions: Greater resistance to HHS occurs in people developing less marked fluctuations of both respiratory and cardiovascular reflex responses. Conversely, wider fluctuations both in control of EpInWel and BP were observed in the event of decreased suspension tolerance or in syncopal events

Clinical Management of Acinic Cell Carcinoma of the Lacrimal Gland

To report a case of acinic cell carcinoma occurred in the lacrimal gland. A 59-year-old man was admitted because of sudden blurring of vision, progressive proptosis of the left eye, and mild double vision in left and down directions of the gaze (Hess-Lancaster test). His medical history detailed controlled bilateral keratoconus and open angle glaucoma. On examination, the best corrected visual acuity decreased from 8/20 till 1/50 in one week. There was a swelling of the left upper eyelid. A hard and tender mass was palpated in the superior temporal left orbit. Ultrasound scan showed an extraconal solid mass, situated in the superior lateral corner of the orbit. Computed tomography and magnetic resonance imaging (MRI) revealed a mass of two centimeters in diameter, with round well-defined outline, within the lacrimal gland. We per-formed an enucleoresection of the mass, via a coronal approach and a lateral orbitotomy by a piezosurgical device. The lesion appeared nodular, brownish, measuring about 2 7 1.5 cm. Histopathological findings were consistent with acinic cell carcinoma with a microcystic, focally papillary-cystic growth of pattern. Follow-up MRI outcomes led to removal of the residual lacrimal gland for suspicion of recurrence. No tumor recurrences where detected at 7-year follow-up

Characterization of the ultrafine and fine particles formed during laser cladding with the Inconel 718 metal powder by means of X-ray spectroscopic techniques

Additive manufacturing is a rapidly growing industrial technology. Still, there is a lack of knowledge regarding the fine particle emission and new particle formation during the processes and their consequences on the performance of the operation and the operator's health as well. Therefore, we studied the properties of the emitted particles during the 3D printing process using the Inconel 718 (Ni-based) superalloy. The number and the mass concentrations were measured with a Scanning Mobility Particle Counter and Sizer. Size-fractionated samples were collected by a cascade impactor, and the elemental composition of the particles was determined by total-reflection X-ray fluorescence analysis, Scanning Electron Microscopy, Energy Dispersive Spectroscopy, and microscopic X-ray fluorescence analysis in the different size fractions. The oxidation states of the metals (Cr, Mn, Fe, Ni) in the samples were determined with the X-ray absorption near-edge structure (XANES) method. Most of the particles were found in the ultrafine region with a size below 100 nm, and the mass size distribution had the maximum at 85 nm. In the original powder, Ni was dominating with appr. 52 wt%, and the proportion of Cr was around 20 wt%, and Mn was below 1 wt%. In the released particles, the Ni content decreased to appr. 26 wt%, the Cr content increased to appr. 47 wt% and Mn increased to around 10 wt% for particles with a size between 0.07 and 10 μm. According to the XANES results, Cr, Mn and Fe were found to be oxidized significantly, whereas Ni remained in the metallic form in the total emitted aerosol containing mostly ultrafine particles. The enrichment and oxidation of metals were correlated with each other

Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

Author Posting. © The Author(s), 2013. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters 23 (2013): 5971-5974, doi:10.1016/j.bmcl.2013.08.057.Human African trypanosomiasis (HAT) is a parasitic neglected tropical disease that affects 10,000 patients each year. Current treatments are sub-optimal, and the disease is fatal if not treated. Herein, we report our continuing efforts to repurpose the human phosphodiesterase 4 (hPDE4) inhibitor piclamilast to target trypanosomal phosphodiesterase TbrPDEB1. We prepared a range of substituted heterocyclic replacements for the 4-amino-3,5-dichloro-pyridine head group of piclamilast, and found that these compounds exhibited weak inhibitory activity of TbrPDEB1.We acknowledge funding from the National Institutes of Health (R01AI082577)

Mental fatigue impairs time trial performance in sub-elite under 23 cyclists

Purpose This study investigates the effect of a mentally demanding response inhibitory task on time trial performance in sub-elite under 23 cyclists. Methods Ten under 23 road cyclists completed two separate testing sessions during which they performed two different cognitive tasks before completing a 30-min time trial on the cycle ergometer. In the experimental condition, 30 min of a standard cognitive task (Stroop task) was used to elicit mental fatigue; in the control condition, a non-demanding activity was carried out. Subjective workload and mood were measured before and after the treatments, and motivation was recorded before the time-trial. During the time trial, power, cadence, heart rate, and rate of perceived exertion were assessed. Blood lactate concentrations and heart rate variability (using the root mean square of the successive differences) were measured before and after the time trial. Results The Stroop task was rated more mentally (P < 0.001) and temporally (P < 0.001) demanding, effortful (P < 0.001), and frustrating (P = 0.001) than the control task; fatigue (P = 0.002) and vigor (P = 0.018) after the cognitive tasks were respectively higher and lower than in the control task. Mean power output (P = 0.007) and cadence (P = 0.043) were negatively affected by the Stroop task, while heart rate (P = 0.349), rating of perceived exertion (P = 0.710), blood lactate concentration (P = 0.850), and root mean square of the successive differences (P = 0.355) did not differ between the two conditions. Conclusion A mentally demanding activity reduced the subsequent physical performance in sub-elite under 23 cyclists. Thus, avoiding cognitive efforts before training and races could improve performance of high-level athletes

Environmental impacts and risk assessment in the re-use of Cr-bearing pyrolyzed tannery wastes: A case study in a residential area

Increasing concern has been raised on the environmental impacts of chromium -tanning wastes recycling. In particular, the pyrolytic conversion of leather industry sludges into Cr(VI)-free carbonized residues is believed to represent a viable route for a sustainable re -use of this type of wastes. The aim of this study was to determine the impact of recycled Cr-bearing pyrolyzed char (named KEU) as backfilling material for road construction in an urban area in Tuscany (Italy). Geochemical and chromium -isotope data, together with microstructural analyses (HR-TEM and XAS), indicate that the presence of KEU results in a significant enhancement of the natural Cr background. The results support the hypothesis that, in environmental conditions, the Cr (III) hosted in KEU is converted into Cr(VI), which is leached out by rainwater. Indeed, Cr(VI) is dispersed in surface water, reaching concentrations up to 18 mg/L and it also occurs in coatings on the surface gravel of unpaved roads. The 53 Cr/ 52 Cr ratio measured in KEU, reported in delta 53 Cr notation, was in the restricted range delta 53 Cr = - 0.031 +/- 0.057 %o ; on the contrary, the delta 53 Cr in water varied between + 1.581 +/- 0.038 %o and + 3.261 +/- 0.191 %o , indicating the reduction of Cr(VI) after the pristine oxidative mobilization. The risk -based soil screening levels (SSLs) for total Cr are well above the concentration measured in soil for all the exposure pathways. On the contrary, the SSL for Cr(VI)indicates that soil contamination poses health hazards for residents