Now the wars are over: The past, present and future of Scottish battlefields

Battlefield archaeology has provided a new way of appreciating historic battlefields. This paper provides a summary of the long history of warfare and conflict in Scotland which has given rise to a large number of battlefield sites. Recent moves to highlight the archaeological importance of these sites, in the form of Historic Scotland’s Battlefields Inventory are discussed, along with some of the problems associated with the preservation and management of these important cultural sites

Contraction of cross-linked actomyosin bundles

Cross-linked actomyosin bundles retract when severed in vivo by laser ablation, or when isolated from the cell and micromanipulated in vitro in the presence of ATP. We identify the time scale for contraction as a viscoelastic time tau, where the viscosity is due to (internal) protein friction. We obtain an estimate of the order of magnitude of the contraction time tau ~ 10-100 s, consistent with available experimental data for circumferential microfilament bundles and stress fibers. Our results are supported by an exactly solvable, hydrodynamic model of a retracting bundle as a cylinder of isotropic, active matter, from which the order of magnitude of the active stress is estimated.Comment: To be published in Physical Biolog

Two-Dimensional Molecular Patterning by Surface-Enhanced Zn-Porphyrin Coordination

In this contribution, we show how zinc-5,10,15,20-meso-tetradodecylporphyrins (Zn-TDPs) self-assemble into stable organized arrays on the surface of graphite, thus positioning their metal center at regular distances from each other, creating a molecular pattern, while retaining the possibility to coordinate additional ligands. We also demonstrate that Zn-TDPs coordinated to 3-nitropyridine display a higher tendency to be adsorbed at the surface of highly oriented pyrolytic graphite (HOPG) than noncoordinated ones. In order to investigate the two-dimensional (2D) self-assembly of coordinated Zn-TDPs, solutions with different relative concentrations of 3-nitropyridine and Zn-TDP were prepared and deposited on the surface of HOPG. STM measurements at the liquid-solid interface reveal that the ratio of coordinated Zn-TDPs over noncoordinated Zn-TDPs is higher at the n-tetradecane/HOPG interface than in n-tetradecane solution. This enhanced binding of the axial ligand at the liquid/solid interface is likely related to the fact that physisorbed Zn-TDPs are better binding sites for nitropyridines.

Teaching introductory undergraduate Physics using commercial video games

Commercial video games are increasingly using sophisticated physics simulations to create a more immersive experience for players. This also makes them a powerful tool for engaging students in learning physics. We provide some examples to show how commercial off-the-shelf games can be used to teach specific topics in introductory undergraduate physics. The examples are selected from a course taught predominantly through the medium of commercial video games.Comment: Accepted to Physics Education, Fig1 does not render properly in this versio

The role of the North Atlantic Oscillation in controlling U.K. butterfly population size and phenology

Copyright @ 2012 The Authors. This article can be accessed from the links below.This article has been made available through the Brunel Open Access Publishing Fund.1. The North Atlantic Oscillation (NAO) exerts considerable control on U.K. weather. This study investigates the impact of the NAO on butterfly abundance and phenology using 34 years of data from the U.K. Butterfly Monitoring Scheme (UKBMS). 2. The study uses a multi-species indicator to show that the NAO does not affect overall U.K. butterfly population size. However, the abundance of bivoltine butterfly species, which have longer flight seasons, were found to be more likely to respond positively to the NAO compared with univoltine species, which show little or a negative response. 3. A positive winter NAO index is associated with warmer weather and earlier flight dates for Anthocharis cardamines (Lepidoptera: Pieridae), Melanargia galathea (Lepidoptera: Nymphalidae), Aphantopus hyperantus (Lepidoptera: Nymphalidae), Pyronia tithonus (Lepidoptera: Nymphalidae), Lasiommata megera (Lepidoptera: Nymphalidae) and Polyommatus icarus (Lepidoptera: Lycaenidae). In bivoltine species, the NAO affects the phenology of the first generation, the timing of which indirectly controls the timing of the second generation. 4. The NAO influences the timing of U.K. butterfly flight seasons more strongly than it influences population size.This study was supported by a multi-agency consortium led by the U.K. Department for Environment, Food and Rural Affairs (Defra), including the Countryside Council for Wales, the Joint Nature Conservation Committee, the Forestry Commission, Natural England, the Natural Environment Research Council, the Northern Ireland Environment Agency and Scottish Natural Heritage. This article is made available through the Brunel Open Access Publishing Fund

Coupling biochemistry and mechanics in cell adhesion: a model for inhomogeneous stress fiber contraction

Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton. The resulting force acts back to the sites of adhesion, resulting in a positive feedback loop for mature adhesion. Here we model this biochemical-mechanical feedback loop for the special case when the actin cytoskeleton is organized in stress fibers, which are contractile bundles of actin filaments. Activation of myosin II molecular motors through the Rho-pathway is described by a system of reaction-diffusion equations, which are coupled into a viscoelastic model for a contractile actin bundle. We find strong spatial gradients in the activation of contractility and in the corresponding deformation pattern of the stress fiber, in good agreement with experimental findings.Comment: Revtex, 35 pages, 13 Postscript figures included, in press with New Journal of Physics, Special Issue on The Physics of the Cytoskeleto

Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study

Background Encephalitis, characterised as inflammation of the brain tissue, is an important cause of acquired brain injury in children. Objective clinical outcomes vary significantly between affected patients, however they do not always correlate with quality of life as reported by parents. The aim of this study was to explore how parents experience and interpret outcomes in relation to their child who has been affected by encephalitis. Methods Data were derived from in-depth, semi-structured interviews, with 15 parents of 12 children and young people affected by encephalitis. Paediatric cases were identified from the retrospective arm of the research programme ‘ENCEPH-UK-Understanding and Improving the Outcome of Encephalitis’, and from the prospective UK childhood meningitis and encephalitis cohort study (UK-ChiMES, 2012 to 2016). Data were analysed thematically. Results Parents’ perspectives on important outcomes for their child and family changed during the different stages of the encephalitis illness trajectory: from acute illness, recovery and rehabilitation, then reintegration into everyday life. Parents’ understanding of their children’s overall outcome was informed by their own experiences, involving comparisons with other children and reflections on their child’s problems before, during and after the acute illness. Conclusion Outcomes in paediatric encephalitis need to be understood in terms of the context of the patient and family experience as well as the timeframe of recovery. The research highlights the need to include more patient, parent and/or carer reported outcome measures during patient assessment, and that assessment should be repeated during recovery as family concerns change. In the longer term, these parameters could be included in clinical and rehabilitation practice to further support child recovery

Towards an agent-based model for risk-based regulation

Risk-based regulation has grown rapidly as a component of Government decision making, and as such, the need for an established evidence-based framework for decisions about risk has become the new mantra. However, the process of brokering scientific evidence is poorly understood and there is a need to improve the transparency of this brokering process and decisions made. This thesis attempts to achieve this by using agent-based simulation to model the influence that power structures and participating personalities has on the brokering of evidence and thereby the confidence-building exercise that characterises risk-based regulation. As a prerequisite to the adoption of agent-based techniques for simulating decisions under uncertainty, this thesis provides a critical review of the influence power structure and personality have on the brokering of scientific evidence that informs risk decisions. Three case studies, each representing a different perspective on risk-based regulation are presented: nuclear waste disposal, the disposal of avian-influenza infected animal carcases and the reduction of dietary salt intake. Semi-structured interviews were conducted with an expert from each case study, and the logical sequence in which decisions were made was mapped out and used to inform the development of an agent-based simulation model. The developed agent-based model was designed to capture the character of the brokering process by transparently setting out how evidence is transmitted from the provider of evidence to the final decision maker. It comprises of two agents, a recipient and provider of evidence, and draws upon a historic knowledge base to permit the user to vary components of the interacting agents and of the decision-making procedure, demonstrating the influence that power structure and personality has on agent receptivity and the confidence attached to a number of different lines of evidence. This is a novel step forward because it goes beyond the scope of current risk management frameworks, for example, permitting the user to explore the influence that participants have in weighing and strengthening different lines of evidence and the impact this has on the final decision outcome.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Vivaldi 1991 - A study of the formation, circulation and ventilation of Eastern North Atlantic Central Water

31 páginas, 10 figuras, 1 tablaA synoptic, hydrographic data set comprising 32 full depth CTD casts and 2500 CTD/SeaSoar profiles to 500 m is used to describe the 0/S properties and circulation of Central Water east of the mid-Atlantic Ridge and between 39°N and 54°N. Eastward transport of 20 x 10 ~ m 3 s l in the North Atlantic Current turns entirely northwards to the west of 54°N, 20°W. This transport consists in the upper layers of Western North Atlantic Water freshened at temperatures below 10°C by mixing with SubArctic Intermediate Water. Northern and Southern branches of the North Atlantic Current are well defined and both turn northwards west of 20°W. A further l0 x l0 s m 3 s "1 of Eastern North Atlantic Water forms and recirculates anticyclonicaily to the west of Spain south of the North Atlantic Current and north of 40°N. Eastern North Atlantic Water is most weakly stratified east of 20°W and there is clear correlation between weakly stratified pycnostads and positive salinity anomalies relative to Western North Atlantic Water. Thus Eastern North Atlantic Water is a winter Mode Water in which strong winter cooling has increased the density and hence also the salinity anomaly at a given temperature. Near the southern entrance to the Rockall Trough there is evidence that salinities are also increased by Mediterranean Water influence. Circulation south of the North Atlantic Current is complex. There is no evidence for direct ventilation southwards across 40°N where water properties (0/S, potential vorticity and CFC-113) and historical data all indicate westward ventilation east of 24°W, with weak southward ventilation occurring further west, in the vicinity of the Azores. The circulation pattern suggested is remarkably similar to that proposed by Helland-Hansen and Nansen in 1926 (The eastern North Atlantic, Geophysiske Publicajoner, 4, 1-76), with anticyclonic circulation of colder Eastern North Atlantic Water north of 40°N meeting warmer water from south of 40°N circulating cyclonically north of the Azores Current. The distribution of pycnostads and 0IS properties between 20°W and 35°W north of the Azores indicates alternate bands of Western and Eastern North Atlantic Water moving eastward and westward respectively, including evidence for westward motion immediately south of the Southern branch of the North Atlantic Current, possibly by westward propagation of anticyclonic eddies containing deep pycnostadsPeer reviewe