A community/faith-based breast health educational program focused on increasing knowledge about triple negative breast cancer among Black women in Prince William County and surrounding areas

Background: Black women have higher rates of Triple-Negative Breast Cancer (TNBC) as compared to women from other racial/ethnic groups. TNBC is a rare form of cancer that is aggressive and more challenging to treat. Little is known about breast health programs designed to educate black women about TNBC. The purpose of this project was to implement a community/faith-based breast health educational program for black women focused on increasing knowledge about TNBC. Methods:This study was an educational program to increase knowledge of TNBC to 450 black women. Knowledge was measured before and after the program. Results: Participants had increased correct knowledge on all three TNBC topics. These items were knowledgeable about potential health concerns of TNBC, TNBC is more common in blacks than whites, and TNBC is potentially one of the more aggressive and deadly forms of breast cancer. Conclusions: Educating black women about TNBC and early detection and mammography screening is vital for survival. This study demonstrates that black women can benefit from culturally appropriate educational programs about TNBC. Increasing knowledge about TNBC can save lives and prevent the harmful consequences associated with this disease among black women

A community/faith-based breast health educational program focused on increasing knowledge about triple negative breast cancer among Black women in Prince William County and surrounding areas

Background: Black women have higher rates of Triple-Negative Breast Cancer (TNBC) as compared to women from other racial/ethnic groups. TNBC is a rare form of cancer that is aggressive and more challenging to treat. Little is known about breast health programs designed to educate black women about TNBC. The purpose of this project was to implement a community/faith-based breast health educational program for black women focused on increasing knowledge about TNBC. Methods:This study was an educational program to increase knowledge of TNBC to 450 black women. Knowledge was measured before and after the program. Results: Participants had increased correct knowledge on all three TNBC topics. These items were knowledgeable about potential health concerns of TNBC, TNBC is more common in blacks than whites, and TNBC is potentially one of the more aggressive and deadly forms of breast cancer. Conclusions: Educating black women about TNBC and early detection and mammography screening is vital for survival. This study demonstrates that black women can benefit from culturally appropriate educational programs about TNBC. Increasing knowledge about TNBC can save lives and prevent the harmful consequences associated with this disease among black women

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele