Cardiac Memory-induced T-wave Inversions

Introduction: Cardiac memory refers to T-wave inversions that result when normal ventricular activation resumes following a period of abnormal ventricular activation.Case Report: We present a case of a 29-year-old man with a pacemaker who presented with new, deep symmetric T-wave inversions caused by cardiac memory.Discussion: Abnormal ventricular activation is most commonly induced by ventricular pacing but can also occur in the setting of transient left bundle branch blocks, ventricular tachycardia, and intermittent ventricular pre-excitation.Conclusion: Recognition of this phenomenon may help to reduce unnecessary admissions, cardiac testing, and cardiac catheterizations

Desenvolvimento de revestimentos poliméricos para liberação controlada de ureia.

Entrada padronizada: RIBEIRO, C

Nutritional Regulation of Gut Barrier Integrity in Weaning Piglets

Simple Summary Weaning is a very stressful period in the piglet's life in intensive farming: it is a sudden process occurring between three to four weeks of age, when the gastrointestinal tract (GIT) is still immature. The GIT is formed by the epithelial, immune and enteric nervous system which controls epithelial barrier integrity as well as gut functions including the transport of luminal nutrients, water and electrolytes. Early weaning is characterized by a breakdown of these gut functions, an increase in intestinal permeability and the appearance of gastrointestinal functional disorders, which can have long-lasting consequences in the pig's life. Weaning, therefore, requires the correct level of nutrients, high quality ingredients, and management, which are directed primarily at encouraging rapid feed intake whilst reducing mortality and morbidity. This review describes the organization of the GIT and highlights the interactions between feed components and the morphology and physiology of the epithelial barrier. Novel dietary strategies focused on improving gut health are also discussed, considering the impacts of selected feed ingredients or additives on the GIT such as functional amino acids, phytochemicals and organic acids. Abstract Weaning is very stressful for piglets and leads to alterations in the intestinal barrier, a reduction in nutrient absorption and a higher susceptibility to intestinal diseases with heavy economic losses. This review describes the structures involved in the intestinal barrier: the epithelial barrier, immune barrier and the enteric nervous system. Here, new insights into the interactions between feed components and the physiology and morphology of the epithelial barrier are highlighted. Dietary strategies focused on improving gut health are also described including amino acids, phytochemicals and organic acids

Methods and application in experimental pharmacology and drug discovery: 2021

Searching for new drugs is an expensive and time-consuming process, but it remains vital for the treatment of many old and new diseases. The availability of current advanced technologies has led to an acceleration of the drug discovery process, facilitating further development of personalized therapies. Sometimes, to obtain the desired therapeutic goals, the drug administration strategy can be of primary importance. Equally important, however, is the understanding of the complex mechanisms of action of new drugs on different cellular and molecular targets, both when the drugs are used alone and when they are administered in combination with other molecules

Fractional diffusions with time-varying coefficients

This paper is concerned with the fractionalized diffusion equations governing the law of the fractional Brownian motion $B_H(t)$. We obtain solutions of these equations which are probability laws extending that of $B_H(t)$. Our analysis is based on McBride fractional operators generalizing the hyper-Bessel operators $L$ and converting their fractional power $L^{\alpha}$ into Erd\'elyi--Kober fractional integrals. We study also probabilistic properties of the r.v.'s whose distributions satisfy space-time fractional equations involving Caputo and Riesz fractional derivatives. Some results emerging from the analysis of fractional equations with time-varying coefficients have the form of distributions of time-changed r.v.'s