The clinical high-risk state for psychosis (CHR-P), Version II

The Clinical High-Risk state for psychosis (CHR-P) paradigm was introduced about 2 decades ago. Over this period of time accumulating knowledge has been gained. Conceptual advancements involve new knowledge into risk enrichment and the impact of recruitment strategies, specificity for prediction of psychotic and nonpsychotic mental disorders and heterogeneity of psychosis risk among the different CHR-P subgroups. The current special issue advances current knowledge on deconstructing the CHR-P paradigm across its 3 subgroups: genetic risk, attenuated psychotic symptoms, and short-lived and remitting psychotic episodes. A conceptual revision of the paradigm (Version II) is suggested and supported by 3 original studies published in this special issue

Analytic Design Techniques for MPT Antenna Arrays

Solar Power Satellites (SPS) represent one of the most interesting technological opportunities to provide large scale, environmentally clean and renewable energy to the Earth [1]‐[3]. A fundamental and critical component of SPSs is the Microwave Power Transmission (MPT) system, which is responsible for the delivery of the collected solar power to the ground rectenna [2]. Towards this end, the MPT array must exhibit a narrow main beam width (), a high beam efficiency (BWBE), and a low peak sidelobe level (). Moreover, reduced realization costs and weights are also necessary [3]. To reach these contrasting goals, several design techniques have been investigated including random methods [4] and hybrid deterministic‐random approaches [2][3]. On the contrary, well‐established design tools based on stochastic optimizers [5][6] are difficult to be employed, due to their high computational costs when dealing with large arrays as those of interest in SPS [3]

A Novel Thermo-Mechanical Model to Assess the Dynamic Thermal Rating of Multi-Span Overhead Transmission Lines

The power flow limits of transmission lines are set in order to ensure a given level of security to the electric system; their improper definition can reduce system reliability, increase the curtailment of renewable energy sources or create barriers to the free trading of energy.Unlike the previous literature, the Dynamic Thermal Rating procedure here proposed takes into account not only that the temperature of conductors can vary span by span for different weather conditions, but also the mechanical interaction between spans, due to their different elongation and to the consequent rotation of insulator strings.The developed tool is able to forecast the time trend of conductor temperatures, tensions, sags and clearances at each span, or to indicate which current can be carried for a given time before a clearance or temperature constraint is violated.Several case studies compares the results of this novel method with the outcomes of the traditional "ruling span" technique, especially when using High-Temperature Low-Sag (HTLS) conductors, having non-linear behaviour with respect to temperature

Iron as Therapeutic Targets in Human Diseases Volume 2

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions