764 research outputs found

    PND8 COST-EFFECTIVENESS AND BUDGET IMPACT ANALYSIS OF SUBCUTANEOUS INTERFERON BETA-1A FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS IN SPAIN

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    A Computational Study in the Detection of English–Spanish Code-Switches

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    Code-switching is the linguistic phenomenon where a multilingual person alternates between two or more languages in a conversation, whether that be spoken or written. This thesis studies the automatic detection of code-switching occurring specifically between English and Spanish in two corpora. Twitter and other social media sites have provided an abundance of linguistic data that is available to researchers to perform countless experiments. Collecting the data is fairly easy if a study is on monolingual text, but if a study requires code-switched data, this becomes a complication as APIs only accept one language as a parameter. This thesis focuses on identifying code-switching in both Twitter data and the Miami-Bangor corpus. This is done by conducting three different experiments. Our first experiment is a logistic regression model where we attempt to distinguish code-switched data from monolingual data. The second experiment is using a novel Word2Vec average nearest neighbor (WANN) classifier based on word embeddings to detect code-switching. The third experiment uses Doc2Vec, where the model uses the mean vector of each document to learn and distinguish between code-switched and monolingual data. Each of these experiments are performed twice, once with tweets and once with the Miami Bangor corpus. The results show that the WANN model performs best on Twitter data. The Doc2Vec model performs best on the Miami Bangor corpus. However, both approaches did well and the performances are comparable

    L'espansione mondiale del cristianesimo nel secondo Novecento

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    Profilo della storia del cristianesimo e delle Chiese nel secondo Novecento fino alla fine della guerra fredda, con attenzione alle dinamiche generali e alle principali vicende dei diversi contesti macroregionali e un approfondimento sul ruolo delle donne nelle Chiese in età contemporanea. INDICE Dinamiche nel protestantesimo nel secondo Novecento - 375, Il cristianesimo tra oppressione, liberazione, giustizia sociale. Le Chiese in America Latina e nei Caraibi - 377, Le Chiese nell’America Settentrionale 386, Il cristianesimo in Africa 391, Le Chiese in India - 394, Le Chiese in Estremo Oriente e nel Sud-Est asiatico 395, Donne, cristianesimo e Chiese nel secondo Novecento - 399, Cambiamenti nel pontificato romano: il 1978 - 401, Alla fine della guerra fredda: il cristianesimo e le Chiese tra dinamiche globali e regionali – 404, Bibliografia ragionata - 40

    Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: An hypothesis

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    In mouse ovaries, the enzyme 3 beta-hydroxysteroid dehydrogenase (HSD) is distributed between microsomes and mitochondria. Throughout the follicular phase of the estrous cycle, the HSD activity in microsomes is predominant; whereas, after LH stimulation, HSD activity during the luteal phase is highest in the mitochondria. The current study examined whether or not LH stimulation always results in an increase in mitochondrial HSD activity. This was accomplished by measuring the HSD activity in microsomal and mitochondrial fractions from ovaries of pregnant mice. These animals have two peaks of LH during gestation, and one peak of LH after parturition. It was found that mitochondrial HSD activity was highest after each peak of LH. It is proposed that mitochondrial HSD is essential for the synthesis of high levels of progesterone. The increase in HSD activity in mitochondria after LH stimulation occurs because: 1) LH initiates the simultaneous synthesis of HSD and the cholesterol side-chain cleavage enzyme (P450scc); and, 2) HSD and P450scc bind together to form a complex, which becomes inserted into the inner membrane of the mitochondria. High levels of progesterone are synthesized by mitochondrial HSD because: 1) the requisite NAD+ cofactor for progesterone synthesis is provided directly by the mitochondria, rather than indirectly via the rate limiting malate-aspartate shuttle; and, 2) the end-product inhibition of P450scc by pregnenolone is eliminated because pregnenolone is converted to progesterone

    Design of a large scale flow-meter test and calibration facility

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    The design and set up of a large-scale flowmeter calibration and test facility is presented. The facility was designed to handle flowmeters with diameters between 6” and 14”, flow rates up to 0.3 m3/s and to give results less than 1% accurate. The calibration methodology consisted firstly in calibrating the pattern flowmeters, using volume and time primary measurements, and secondly, comparing the pattern to the flowmeters needing calibration. The design and calculation of the primary calibration device is addressed, including numerical simulations of the outflow manifold and the comparison to experimental data. The calibration facility proved to be accurate and reliable in producing renewed calibration data for various tested flowmeter

    Design of a flow deflector for an accurate flow meter calibration facility

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    The design and test of a flow deflector gate used for controlling the flow deviation toward the primary tank in a flow-meter calibration facility is presented. The deflector gate is pneumatically controlled and permits the flow conduction to either the suction tank or to the primary tank. The deflector is designed to approximately compensate the flow deficit towards the primary tank during the opening, with the flow excess while in the shutting process. Numerical simulations are performed to study the flow hydrodynamics during the deflector operation. Results are compared to experimental data, and used to improve the gate design. The enhanced design proved to guarantee the uniformity of the flow through the calibration section and the dramatic reduction of the error in volume measurement during calibration

    Design of a large scale flow-meter test and calibration facility

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    The design and set up of a large-scale flowmeter calibration and test facility is presented. The facility was designed to handle flowmeters with diameters between 6” and 14”, flow rates up to 0.3 m3/s and to give results less than 1% accurate. The calibration methodology consisted firstly in calibrating the pattern flowmeters, using volume and time primary measurements, and secondly, comparing the pattern to the flowmeters needing calibration. The design and calculation of the primary calibration device is addressed, including numerical simulations of the outflow manifold and the comparison to experimental data. The calibration facility proved to be accurate and reliable in producing renewed calibration data for various tested flowmeter

    Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

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    PMCID: PMC3544714This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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