Pharmacological correction of endothelial dysfunction using ademethionin and taurine

It is noted that ademethionine and taurine have an endothelioprotective effect because of their ability to decrease hyperhomocysteinemia The investigated drugs showed pronounced endothelioprotective activity and can be recommended for further pre-clinical studie

Pancreatogenic infections: importance of microbiological monitoring and penetration of antimicrobial chemotherapeutic agents into the pancreas when defining therapeutic approach

The review provides the information on the spectrum of microorganisms initiating the development of clinical and morphological forms of pancreatogenic infections. It is shown that when analyzing pathological conditions, no features in the microbiological landscape of the secondary infection in the pancreas and the surrounding extraperitoneal cellular tissue are registere

Endothelioprotective property of the combination of the thioctic acid and rosuvastatin shown in the endothelial dysfunction models

During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same of female rats was performed by bilateral ovarioectomy and further intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7. The deficiency of nitric oxide as a result of the NO-synthase blockade was accompanied by the impairment of the endotheliumdependent and independent vasodilatation estimated in the pharmacological tests, which was expressed in the increasing coefficient of endothelial dysfunctio

Use of L-arginine immobilised on activated carbon for pharmacological correction of endothelial disfunction

For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environmen

Assessment of senior dental students and dental residents in matters of antimicrobial chemotherapy

This article highlights the results of the study designed to assess knowledge of senior dental students of medical schools and dental residents on the main issues of antibiotic therapy and the empirical use of antimicrobials for treatment of respiratory disorde

Effect of antagonist mineralocorticoid receptors Eplerenon on the dynamics of QT interval dispersion in patients with acute elderly aged

Currently, there is an increase in the frequency of cardiovascular diseases, including acute coronary syndrome (ACS), while in the Russian Federation due to ACS there is a high mortality rate from sudden cardiac death (SCD). The aim of the work is a comparative analysis of the effect of mineralocorticoid receptor antagonists (MRA) of eplerenone on the predictors of SCD development in patients with ST elevation myocardial infarction (STEMI) with a moderately abnormal ejection fraction(EF) of the left ventricle (LV) in the early stages of the diseas

The effect of arginase ii selective inhibitors on the functional parameters of experimental animals in ADMA–like preeclampsia

Perinatal mortality rate and the rate of preterm birth (10-12%) in pregnant women with hypertensive disorders far outweigh the corresponding values in women with physiological pregnancy. Despite such close attention worldwide to this problem, today the number of this complication has no tendency to decreas

Renoprotective effect of carbamylated darbepoetin and udenafil in ischemia-reperfusion of rat kidney due to the effect of preconditioning and inhibition of nuclear factor kappa B

Pharmacological preconditioning with carbamylated darbepoetin and udenafil reduces the severity of acute kidney injury induced by ischemia-reperfusio

Betahistine: targeting on vascular wall aging

Betahistine are routine drug in neurological practice, which is used to correct vertigo. The clinical efficacy of this drug can be caused not only by neuro-, but also by endotheliotropic action. In this review, the main information on the potential mechanisms for the implementation of vasoprotection, including metabolic, NO-ergic, anti-inflammatory and other components of the action are discusse

Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach

Mesenchymal stem (stromal) cells (MSCs) are self-renewing, cultured adult stem cells which secrete a complex set of multiple soluble biologically active molecules. Different population of MSCs can secret different factors which could have anti-inflammatory, anti-apoptotic, anti-fibrotic activities, a neuroprotective effect. The paracrine activity of conditioned medium obtained when cultivating MSCs, due to a plethora of bioactive factors, was assumed to have the most prominent cell-free therapeutic impact and can serve as a better option in the field of regenerative medicine in futur