It is noted that ademethionine and taurine have an endothelioprotective effect because of their ability to decrease hyperhomocysteinemia The investigated drugs showed pronounced endothelioprotective activity and can be recommended for further pre-clinical studie

Belousova, Y. V.

Khadieva, T. A.

Pokrovskaya, T. G.

English

Introduction: Рharmacological correction of endothelial dysfunction is a urgent problem of modern medicine.
        
          Materials and methods: Endothelial dysfunction was simulated in male rats using the e-NOS inhibitor L-NAME (25 mg/kg/day intraperitoneally, for 7 days). Simulation of ADMA-like preeclampsia was performed by intraperitoneal injection of L-NAME to females in the same doses for 7 days (14-20th days of pregnancy). These pathologies were corrected by administering ademethionine in dose 150 mg/kg and taurine at a dose of 260 mg/kg, as well as their combination at the same doses, intragastrically, through an atraumatic probe, once a day.
        
          Results: In the group with use of taurine at a dose of 260 mg/kg the coefficient of endothelial dysfunction decreased to the level of intact animals. Use of ademethionine at a dose of 150 mg/kg and taurine at a dose of 260 mg/kg combined resulted in the most pronounced endothelioprotective effect on the ADMA-like preeclampsia model. The coefficient of endothelial dysfunction decreased more than when using monotherapy of these drugs. Morphological studies of myocardiocytes showed that the combination of ademethionine at a dose of 150 mg/kg and taurine at a dose of 260 mg/kg prevented an increase in the cross-section of cardiomyocytes.
        
          Discussion: Possibly, ademethionine and taurine have an endothelioprotective effect because of their ability to decrease hyperhomocysteinemia.
        
          Conclusion: The investigated drugs showed pronounced endothelioprotective activity and can be recommended for further pre-clinical studies

Khadieva, Taisiya A.

Pokrovskaya, Tatiana G.

Belousova, Yulia

ZENODO

Pharmacological correction of endothelial dysfunction using ademethionin and taurine

DSpace at Belgorod State University

Khadieva,Taisia

Pokrovskaia,Tatyana

Belousova,Yulia

ARPHA OAI-PMH Endpoint

ARPHA Preprints

National Open Repository Aggregator (NORA)

Endothelial dysfunction was simulated in male rats using the e-NOS inhibitor L-NAME (25 mg/kg/day intraperitoneally, for 7 days). Simulation of ADMA-like preeclampsia was performed by intraperitoneal injection of L-NAME to females in the same doses for 7 days (14-20th days of pregnancy). These pathologies were corrected by administering ademethionine in dose 150 mg/kg and taurine at a dose of 260 mg/kg, as well as their combination at the same doses, intragastrically, through an atraumatic probe, once a da

Kladieva, T. A.

Belousova, Yu. V.

https://zenodo.org/record/2652642/files/32730_PDF_1_191634_LE_295580.pdf

Pharmacological correction of endothelial dysfunction using ademethionin and taurine

Abstract

Similar works

Full text

Available Versions

ZENODO

DSpace at Belgorod State University

ARPHA OAI-PMH Endpoint

ARPHA Preprints

DSpace at Belgorod State University

National Open Repository Aggregator (NORA)

DSpace at Belgorod State University