The subgenomic promoter of brome mosaic virus folds into a stem-loop structure capped by a pseudo-triloop that is structurally similar to the triloop of the genomic promoter

Supramolecular & Biomaterials Chemistr

Structure and photophysical properties of a series of new 1D d 10 Coinage Metal Organic Chalcogenolates (MOCs): [M(o-SPhCO2H)]n (M = Cu, Ag, Au)

SSCI-VIDE+CDFA+OVE:ADMInternational audienceThiosalicylic acid is hard-soft donor ligand, able to coordinate numerous metals [1]. A significant number of coordination compounds of d10 metals have been reported. However, crystallographic studies of polymeric species stayed very limited compared to their mono- and oligomeric counterparts. For example, preparation of polymeric [Au(oSCPhCO2H)]n has been reported [2], as well as polymeric compounds of silver thiosalicylate [3], but no crystallographic structure was reported. A number of Cu(II) thiosalicylates [4], a mixed-valence Cu(I)2Cu(II) complex [5] and no Cu(I) complexes have been described up to our knowledge. In most cases structural studies are precluded due to the strong affinity between sulfur and coinage metals, inducing a rapid precipitation of coordination polymers making single crystals hardly obtainable. In presented work, we report extensive pioneering structural study of three polymeric species of Cu(I), Au(I) and Ag(I). Structural study was performed by means of powder X-ray diffraction and PDF (pair distribution function) calculations. These coordination polymers have similar 1D structures. Based on this fact, we are able to discuss the influence of the structure and the nature of the metallic ion on photophysical properties of these materials. They emin in orange to NIR part of the spectrum. High quantum yields make them interesting for illumination and as NIR-emitters. [1] T. Wehr-Candler et al. Coord. Chem. Rev. 2016, 313, 111.[2] R.E. Bachman et al. Z. Naturforsch. 2009, 64B, 1491. [3] K. Nomiya et al. J. Inorg. Biochem. 1995, 58, 255. [4] See for example M.S. Abu-Bakr, Monatsh. Chem. 1997, 128, 563. [5] R.C. Bott et al. Chem. Commun. 1998, 2403

An intrinsic dual-emitting gold thiolate coordination polymer, [Au( plus I)(p-SPhCO2H)](n), for ratiometric temperature sensing

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Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA

The development of synthetic agents that recognize double-stranded DNA (dsDNA) is a long-standing goal that is inspired by the promise for tools that detect, regulate, and modify genes. Progress has been made with triplex-forming oligonucleotides, peptide nucleic acids, and polyamides, but substantial efforts are currently devoted to the development of alternative strategies that overcome the limitations observed with the classic approaches. In 2005, we introduced Invader locked nucleic acids (LNAs), i.e., double-stranded probes that are activated for mixed-sequence recognition of dsDNA through modification with “+1 interstrand zippers” of 2′-<i>N</i>-(pyren-1-yl)­methyl-2′-amino-α-l-LNA monomers. Despite promising preliminary results, progress has been slow because of the synthetic complexity of the building blocks. Here we describe a study that led to the identification of two simpler classes of Invader monomers. We compare the thermal denaturation characteristics of double-stranded probes featuring different interstrand zippers of pyrene-functionalized monomers based on 2′-amino-α-l-LNA, 2′-<i>N</i>-methyl-2′-amino-DNA, and RNA scaffolds. Insights from fluorescence spectroscopy, molecular modeling, and NMR spectroscopy are used to elucidate the structural factors that govern probe activation. We demonstrate that probes with +1 zippers of 2′-<i>O</i>-(pyren-1-yl)­methyl-RNA or 2′-<i>N</i>-methyl-2′-<i>N</i>-(pyren-1-yl)­methyl-2′-amino-DNA monomers recognize DNA hairpins with similar efficiency as original Invader LNAs. Access to synthetically simple monomers will accelerate the use of Invader-mediated dsDNA recognition for applications in molecular biology and nucleic acid diagnostics