2,623 research outputs found
An analysis of interplanetary solar radio emissions associated with a coronal mass ejection
Coronal mass ejections (CMEs) are large-scale eruptions of magnetized plasma
that may cause severe geomagnetic storms if Earth-directed. Here we report a
rare instance with comprehensive in situ and remote sensing observa- tions of a
CME combining white-light, radio, and plasma measurements from four different
vantage points. For the first time, we have successfully applied a radio
direction-finding technique to an interplanetary type II burst detected by two
identical widely separated radio receivers. The derived locations of the type
II and type III bursts are in general agreement with the white light CME recon-
struction. We find that the radio emission arises from the flanks of the CME,
and are most likely associated with the CME-driven shock. Our work demon-
strates the complementarity between radio triangulation and 3D reconstruction
techniques for space weather applications
Safety and Feasibility of Long-term Intravenous Sodium Nitrite Infusion in Healthy Volunteers
BACKGROUND: Infusion of sodium nitrite could provide sustained therapeutic concentrations of nitric oxide (NO) for the treatment of a variety of vascular disorders. The study was developed to determine the safety and feasibility of prolonged sodium nitrite infusion. METHODOLOGY: Healthy volunteers, aged 21 to 60 years old, were candidates for the study performed at the National Institutes of Health (NIH; protocol 05-N-0075) between July 2007 and August 2008. All subjects provided written consent to participate. Twelve subjects (5 males, 7 females; mean age, 38.8±9.2 years (range, 21-56 years)) were intravenously infused with increasing doses of sodium nitrite for 48 hours (starting dose at 4.2 µg/kg/hr; maximal dose of 533.8 µg/kg/hr). Clinical, physiologic and laboratory data before, during and after infusion were analyzed. FINDINGS: The maximal tolerated dose for intravenous infusion of sodium nitrite was 267 µg/kg/hr. Dose limiting toxicity occurred at 446 µg/kg/hr. Toxicity included a transient asymptomatic decrease of mean arterial blood pressure (more than 15 mmHg) and/or an asymptomatic increase of methemoglobin level above 5%. Nitrite, nitrate, S-nitrosothiols concentrations in plasma and whole blood increased in all subjects and returned to preinfusion baseline values within 12 hours after cessation of the infusion. The mean half-life of nitrite estimated at maximal tolerated dose was 45.3 minutes for plasma and 51.4 minutes for whole blood. CONCLUSION: Sodium nitrite can be safely infused intravenously at defined concentrations for prolonged intervals. These results should be valuable for developing studies to investigate new NO treatment paradigms for a variety of clinical disorders, including cerebral vasospasm after subarachnoid hemorrhage, and ischemia of the heart, liver, kidney and brain, as well as organ transplants, blood-brain barrier modulation and pulmonary hypertension. CLINICAL TRIAL REGISTRATION INFORMATION: http://www.clinicaltrials.gov; NCT00103025
The STAR Silicon Strip Detector (SSD)
The STAR Silicon Strip Detector (SSD) completes the three layers of the
Silicon Vertex Tracker (SVT) to make an inner tracking system located inside
the Time Projection Chamber (TPC). This additional fourth layer provides two
dimensional hit position and energy loss measurements for charged particles,
improving the extrapolation of TPC tracks through SVT hits. To match the high
multiplicity of central Au+Au collisions at RHIC the double sided silicon strip
technology was chosen which makes the SSD a half million channels detector.
Dedicated electronics have been designed for both readout and control. Also a
novel technique of bonding, the Tape Automated Bonding (TAB), was used to
fullfill the large number of bounds to be done. All aspects of the SSD are
shortly described here and test performances of produced detection modules as
well as simulated results on hit reconstruction are given.Comment: 11 pages, 8 figures, 1 tabl
Strange Meson Enhancement in PbPb Collisions
The NA44 Collaboration has measured yields and differential distributions of
K+, K-, pi+, pi- in transverse kinetic energy and rapidity, around the
center-of-mass rapidity in 158 A GeV/c Pb+Pb collisions at the CERN SPS. A
considerable enhancement of K+ production per pi is observed, as compared to
p+p collisions at this energy. To illustrate the importance of secondary hadron
rescattering as an enhancement mechanism, we compare strangeness production at
the SPS and AGS with predictions of the transport model RQMD.Comment: 11 pages, including 4 figures, LATE
DNA content of a functioning chicken kinetochore
© The Author(s) 2014. In order to understand the three-dimensional structure of the functional kinetochore in vertebrates, we require a complete list and stoichiometry for the protein components of the kinetochore, which can be provided by genetic and proteomic experiments. We also need to know how the chromatin-containing CENP-A, which makes up the structural foundation for the kinetochore, is folded, and how much of that DNA is involved in assembling the kinetochore. In this MS, we demonstrate that functioning metaphase kinetochores in chicken DT40 cells contain roughly 50 kb of DNA, an amount that corresponds extremely closely to the length of chromosomal DNA associated with CENP-A in ChIP-seq experiments. Thus, during kinetochore assembly, CENP-A chromatin is compacted into the inner kinetochore plate without including significant amounts of flanking pericentromeric heterochromatin. © 2014 The Author(s).Wellcome Trust [grant number 073915]; Wellcome Trust Centre for Cell Biology (core grant numbers 077707 and 092076); Darwin Trust of Edinburg
Two-kaon correlations in central Pb + Pb collisions at 158 A GeV/c
Two-particle interferometry of positive kaons is studied in Pb + Pb
collisions at mean transverse momenta and 0.91 GeV/c. A
three-dimensional analysis was applied to the lower data, while a
two-dimensional analysis was used for the higher data. We find that the
source size parameters are consistent with the scaling curve observed in
pion correlation measurements in the same collisions, and that the duration
time of kaon emission is consistent with zero within the experimental
sensitivity.Comment: 4 pages incl. 1 table and 3 fig's; RevTeX; accepted for publication
in PR
Phase-space dependence of particle-ratio fluctuations in Pb+Pb collisions from 20A to 158A GeV beam energy
A novel approach, the identity method, was used for particle identification
and the study of fluctuations of particle yield ratios in Pb+Pb collisions at
the CERN Super Proton Synchrotron (SPS). This procedure allows to unfold the
moments of the unknown multiplicity distributions of protons (p), kaons (K),
pions () and electrons (e). Using these moments the excitation function of
the fluctuation measure [A,B] was measured, with A and
B denoting different particle types. The obtained energy dependence of
agrees with previously published NA49 results on the related
measure . Moreover, was found to depend
on the phase space coverage for [K,p] and [K,] pairs. This feature most
likely explains the reported differences between measurements of NA49 and those
of STAR in central Au+Au collisions
Bose-Einstein correlations of pion pairs in central Pb+Pb collisions at CERN SPS energies
Measurements of Bose-Einstein correlations of pion pairs in central Pb+Pb
collisions were performed with the NA49 detector at the CERN SPS for beam
energies of 20A, 30A, 40A, 80A, and 158A GeV. Correlation functions were
measured in the longitudinally co-moving ``out-side-long'' reference frame as a
function of rapidity and transverse momentum in the forward hemisphere of the
reaction. Radius and correlation strength parameters were obtained from fits of
a Gaussian parametrization. The results show a decrease of the radius
parameters with increasing transverse momentum characteristic of strong radial
flow in the pion source. No striking dependence on pion-pair rapidity or beam
energy is observed. Static and dynamic properties of the pion source are
obtained from simultaneous fits with a blast-wave model to radius parameters
and midrapidity transverse momentum spectra. Predictions of hydrodynamic and
microscopic models of Pb+Pb collisions are discussed.Comment: 22 pages, 23 figure
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