Urazy sportowe kobiet w wybranych grach zespołowych

Professional and recreational physical activity, is connected with a danger of injuries of locomotor system. Despite of a positive influence of physical motion on the human body, too much of workload makes the body exposed to rise up micro- and makrotrauma. Each sport discipline is characterized by its own rules and specificity of the game and training. Team games are distinguished by a large variable of factors influencing the athlete. The most traumatic sports disciplines are football and volleyball. The aim of the research was to evaluate and compare the injuries occurring in women training one of the above-mentioned disciplines. It has been shown that in both football and volleyball players, sprains of the ankle joint were the most common injuries in the lower limb, followed immediately by tears / ruptures of the knee ligaments. In the area of the upper limb, in footballers, a high percentage of shoulder contusions was noted, which may be related to the contact nature of the game. Volleyball players more often suffered injuries of the phalanges.Uprawianie sportu, wyczynowo lub rekreacyjnie, wiąże się z niebezpieczeństwem urazów narządu ruchu. Mimo pozytywnego wpływu ruchu fizycznego na organizm człowieka, zbyt duże obciążenie pracą naraża organizm na powstawanie mikro- i makrotraumy. Każda dyscyplina sportu charakteryzuje się własnymi zasadami oraz specyfiką gry i treningu. Gry zespołowe wyróżnia duża zmienna czynników wpływających na sportowca. Najbardziej traumatyczne dyscypliny sportowe to piłka nożna i siatkówka. Celem badań była ocena i porównanie urazów występujących u kobiet trenujących jedną z ww. dyscyplin. Wykazano, że zarówno u piłkarzy, jak i siatkarzy najczęstszymi urazami kończyny dolnej były skręcenia stawu skokowego, a zaraz po nich naderwania/naderwania więzadeł stawu kolanowego. W okolicy kończyny górnej u piłkarzy odnotowano wysoki odsetek kontuzji barku, co może mieć związek z kontaktowym charakterem gry. Siatkarze częściej doznawali kontuzji paliczków

All-cause readmission and repeat revascularization after percutaneous coronary intervention

Background: Percutaneous coronary intervention (PCI) is one of the most frequently performed cardiac interventions. However, there is limited data regarding the cause of recurrent hospitalization and repeat revascularization. The aim of this study was to assess re-hospitalization and repeat revascularization within 30 days of the initial hospitalization for PCI, using data from Opolskie Voivodeship, National Health Fund (NHF) Registry. Methods: The study population consisted of all PCI patients treated in three interventional cardiology laboratories in Opolskie Voivodeship in Poland between 1 July 2008 and 30 June 2009. All PCI patients who died during the initial hospitalization or who were transferred to other units were excluded from the analysis. The study end-point comprised 30 day all-cause readmission and repeat revascularization. Results: A total of 2,039 PCI patients were included in the analysis. The all-cause 30-day readmission rate was 14.6%. The 30-day readmission rate of acute coronary syndrome (ACS) patients was significantly higher compared to the stable coronary disease patients (ACS 15.8%, non-ACS 10.7%, p = 0.008). The 30-day readmission rate did not differ between the three cardiac laboratories. Approximately half (46.2%) of all readmitted patients underwent a repeat revascularization procedure, mainly in the form of PCI. The overall all-cause 30-day mortality rate was 0.8%. Compared to the PCI patients who did not require readmission, the readmitted patients had a significantly higher all-cause 30-day mortality rate (3.6% vs 0.3%, p < 0.001). Conclusions: Almost one in seven PCI patients requires readmission within 30 days of hospital discharge. Approximately 50% of all readmitted PCI patients resulted in a repeat revascularization procedure. PCI patients who were readmitted within 30 days of an index PCI procedure had a significantly higher all-cause 30-day mortality rate. (Cardiol J 2012; 19, 2: 174&#8211;179

Ferritin and transferrin saturation cannot be used to diagnose iron-deficiency anemia in critically ill patients

Abstract Introduction: Iron-deficiency anaemia (IDA) is the most common anaemia globally. The frequency of IDA among critically ill patients is not known. The aim of our study was to analyse performance of standard iron metabolism parameters in diagnosis of IDA in the critically ill. Material and methods: We performed a retrospective analysis of consecutive anaemic patients admitted to the intensive care unit. Based on various cut-off values for ferritin and/or transferrin saturation (TfS), we determined the incidence of IDA. Results: The population consisted of 27 (53%) men and 24 (47%) women. The median haemoglobin concentration was well 96 [interquartile range (IQR 87–109)] g/L. The studied population had markedly increased concentration of C-reactive protein [119 (IQR 44–196) mg/L], ferritin [686 (385–1114) µg/L], whereas iron concentration and TfS were below reference value. Depending on cut-off value chosen, IDA could be diagnosed in between 7.8 (ferritin &lt; 100 µg/L +TfS &lt; 20%) and 56.9 % (TfS &lt; 20%) of patients. Conclusions: Ferritin and transferrin saturation cannot be used for precise diagnosis of IDA caused by absolute or functional iron deficiency in the critically ill

Sheep and Horse Grazing in a Large-Scale Protection Area and its Positive Impact on Chemical and Biological Soil Properties

This paper looks into the impact of free grazing by sheep and horses on the chemical and biological properties of soils in the partial protection zone of the Roztocze National Park. The study sampled three different types of pastureland in the area: pastures for sheep, horses and for combined grazing by sheep and horses. Compared to an ungrazed reference pasture, free grazing significantly stimulated the activity of enzymes which catalyze the transformation of organic matter (dehydrogenases, phosphatases and ureases) and it also positively influenced other chemical properties of the soils. Among the soils under free-grazing management, the pasture grazed to horses underwent the most advantageous changes in terms of the eco-chemical status of the soil

Thrombocytopenia in critically ill patients: single center data analysis

Introduction: Thrombocytopenia (TP) is one of the most frequent abnormalities of hemostasis found in laboratory tests in critically ill patients. The aim of this study was to determine the frequency and most probable causes of TP in patients hospitalized in the Intensive Care Unit (ICU). Material and methods: The documentation of all patients hospitalized in 2019 was analyzed retrospectively in the ICU of the university hospital. Patients diagnosed with TP at admission to the ward or during hospitalization were identified. Potential factors influencing the platelet count were analyzed. Results: During the analyzed period, 291 patients were hospitalized. In 93 patients (32%), TP was diagnosed, including 61 patients at admission (21%), and the remaining 32 patients (11%) during hospitalization. Patients with TP had higher SAPS II, APACHE II and SOFA scores than patients without TP (p &lt;0.001 for all). Mortality in patients with TP was twice as high as in patients without TP (58% vs. 29%, p &lt;0.001). In 18 patients (6%), only one cause of TP was potentially identified, while in 39 patients (13%), four or more factors that could potentially cause TP were identified. Conclusions: Thrombocytopenia is a relatively common problem in the critically ill population, but due to the challenges in differential diagnosis, a reliable assessment of the causes of its occurrence is difficult

P2Y12 antagonist ticagrelor inhibits the release of procoagulant extracellular vesicles from activated platelets

Background: Activated platelets release platelet extracellular vesicles (PEVs). Adenosine diphosphate(ADP) receptors P2Y1 and P2Y12 both play a role in platelet activation, The present hypothesis hereinis that the inhibition of these receptors may affect the release of PEVs.Methods: Platelet-rich plasma from 10 healthy subjects was incubated with saline, P2Y1 antagonistMRS2179 (100 μM), P2Y12 antagonist ticagrelor (1 μM), and a combination of both antagonists.Platelets were activated by ADP (10 μM) under stirring conditions at 37°C. Platelet reactivity wasassessed by impedance aggregometry. Concentrations of PEVs– (positive for CD61 but negative forP-selectin and phosphatidylserine) and PEVs+ (positive for all) were determined by a state-of-the-artflow cytometer. Procoagulant activity of PEVs was measured by a fibrin generation test.Results: ADP-induced aggregation (57 ± 13 area under curve {AUC] units) was inhibited 73%by the P2Y1 antagonist, 86% by the P2Y12 antagonist, and 95% when combined (p &lt; 0.001 for all).The release of PEVs– (2.9 E ± 0.8 × 108/mL) was inhibited 48% in the presence of both antagonists(p = 0.015), whereas antagonists alone were ineffective. The release of PEVs+ (2.4 ± 1.6 × 107/mL)was unaffected by the P2Y1 antagonist, but was 62% inhibited by the P2Y12 antagonist (p = 0.035),and 72% by both antagonists (p = 0.022). PEVs promoted coagulation in presence of tissue factor.Conclusions: Inhibition of P2Y1 and P2Y12 receptors reduces platelet aggregation and affects therelease of distinct subpopulations of PEVs. Ticagrelor decreases the release of procoagulant PEVs fromactivated platelets, which may contribute to the observed clinical benefits in patients treated with ticagrelor

Long-term outcomes of cardiac resynchronization therapy are worse in patients who require atrioventricular junction ablation for atrial fibrillation than in those with sinus rhythm

Background: The aim of the study was to assess the impact of atrial fibrillation (AF) with and without the need for atrioventricular junction (AVJ) ablation on outcomes in patients undergoing cardiac resynchronization therapy (CRT).Methods: A single center cohort of 200 consecutive CRT patients was divided into three groups: 1) AF with CRT pacing &lt; 95% in which AVJ ablation was performed (AF-ABL, n = 40; 20%), 2) AF without the need for AVJ ablation (AF-non ABL, n = 40; 20%), 3) sinus rhythm (SR, n = 120; 60%). All patients were assessed before CRT implantation and at 6-month follow-up. Positive clinical response to CRT was considered alive status without the need for heart transplantation and improvement ≥ 1 NYHA after 6 months. The comparative analysis among all study groups with respect to response-rate and long-term survival was performed.Results: The 6-month response-rate in both AF-ABL and AF-nonABL was significantly lower than in SR (52.5 and 50 vs.77.5%, respectively; both p &lt; 0.017), though there were no differences in baseline characteristics among study groups apart from higher baseline NT-proBNP levels in AF-ABL. However, after adjustment for this confounder, and despite optimal CRT pacing burden in study groups, the remote all-cause mortality during median follow-up of 36.1 months was significantly higher in AF-ABL than in SR (adjusted HR = 2.57, 95% CI 1.09–6.02, p = 0.03). What is more, no difference in long-term survival between SR and AF-nonABL was observed.Conclusions: Despite the improvement of CRT pacing burden and thus response-rate up to the level of AF subjects without the need for ablation, the long-term survival of AF patients requiring AVJ ablation remains still worse than in SR

Analysis of ibrutinib efficacy in a subgroup of chronic lymphocytic leukemia patients with 17p deletion: observational study of the Polish Adult Leukemia Group (PALG)

BackgroundThe 17p deletion is regarded as the strongest poor prognostic factor in chronic lymphocytic leukemia (CLL). Results of recently performed clinical trials have suggested that ibrutinib significantly improves the outcome in this patient group.AimThe study aimed at analyzing the efficacy and adverse events profile of ibrutinib monotherapy in CLL patients with 17p deletion treated in routine clinical practice outside clinical trials.Materials and MethodsClinical response and adverse events profile of ibrutinib monotherapy were assessed in thirty-five CLL patients with 17p deletion treated within the ibrutinib named patients program in Poland.ResultsOverall response rate was 80% (28/35 patients) with median observation time of 24.2 months (range 0,1 – 30,9). Complete remission was observed in 5 patients (14.3%), partial remission in 11 (31.4%), partial remission with lymphocytosis in 13 (37.1%), whereas stable disease and progression was noted in 4 (11.4%) and 1 (2.9%) respectively. Response was not assessed in 1 patient. Median progression-free survival was 29.5 months, whereas median overall survival was not reached. Eleven patients died (7 because of infection, 1 of CLL progression, 1 of sudden cardiac death, 1 of disseminated breast cancer and 1 of unknown causes). In 13 patients (37.1%) at least one 3 or 4 grade adverse event occurred. In 11 patients (31.4%) the treatment was temporary withheld or the dose reduced due to adverse events.ConclusionIbrutinib is characterized by high clinical efficacy and acceptable toxicity in CLL patients with 17p deletion in daily clinical practice

"Competitiveness of the Warsaw Stock Exchange based on M. Porter's model"

Celem pracy jest zbadanie oraz ocena pozycji konkurencyjnej Giełdy Papierów Wartościowych w Warszawie na tle giełd z Europy Środkowo – Wschodniej takich jak giełda z Pragi, Wiednia oraz Budapesztu jak i również na tle większego i bardziej znaczącego podmiotu, którego wielkość możemy ciągle porównać do giełdy w Polsce, czyli Giełdy Papierów Wartościowych w Oslo. W wyniku przeprowadzonych badań w pracy udało się określić, jej pozycję w regionie oraz jakie stoją przed nią perspektywy na rozwój.The purpose of the thesis is to analyse and to assess the competitive position of the Warsaw Stock Exchange in compare to the stock exchanges in European Middle – East region like Vienna CEESG, Prague CEESG, Budapest Stock Exchange and with more valuable subject which can still be comparable – Oslo Stock Exchange. As a result of my analysis I asses its competitive position in a region and prospects for future development