BIOMETRIC ANALYSIS OF A GROWTH RESPONSE OF TWO PLANT SPECIES IN A RADIOACTIVE WASTE AREA

Lengths of pistillate inflorescences of sedges (Carex spp.) growing in the contaminated soils of White Oak Lake bed were measured in relation to radiation fields. Carex Frankii Kunth and Carex vulpinoidea Michx. populations were sampled from areas with air dose rates of 0, 10, 20, and 40 mr/hr. Analyses of variance showed that mean lengths of inflorescences of C. vulpinoidea were simllar to each other in these areas but that those of C. Frankii were significantly different. However, the sites differ in such factors as soil moisture, fertility, and alkalinity, so that these differences in the length of inflorescence may not be accounted for primarily by the exposure dose rate of the radiation field. (auth

APRIL:TACI axis is dispensable for the immune response to rabies vaccination.

There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings. To accomplish this goal, rabies virus (RABV)-based vaccines must rapidly activate B cells to secrete antibodies which neutralize pathogenic RABV before it enters the CNS. Increased understanding of how B cells effectively respond to RABV-based vaccines may improve efforts to simplify post-exposure prophylaxis (PEP) regimens. Several studies have successfully employed the TNF family cytokine a proliferation-inducing ligand (APRIL) as a vaccine adjuvant. APRIL binds to the receptors TACI and B cell maturation antigen (BCMA)-expressed by B cells in various stages of maturation-with high affinity. We discovered that RABV-infected primary murine B cells upregulate APRIL ex vivo. Cytokines present at the time of antigen exposure affect the outcome of vaccination by influencing T and B cell activation and GC formation. Therefore, we hypothesized that the presence of APRIL at the time of RABV-based vaccine antigen exposure would support the generation of protective antibodies against RABV glycoprotein (G). In an effort to improve the response to RABV vaccination, we constructed and characterized a live recombinant RABV-based vaccine vector which expresses murine APRIL (rRABV-APRIL). Immunogenicity testing in mice demonstrated that expressing APRIL from the RABV genome does not impact the primary antibody response against RABV G compared to RABV alone. In order to evaluate the necessity of APRIL for the response to rabies vaccination, we compared the responses of APRIL-deficient and wild-type mice to immunization with rRABV. APRIL deficiency does not affect the primary antibody response to vaccination. Furthermore, APRIL expression by the vaccine did not improve the generation of long-lived antibody-secreting plasma cells (PCs) as serum antibody levels were equivalent in response to rRABV-APRIL and the vector eight weeks after immunization. Moreover, APRIL is dispensable for the long-lived antibody-secreting PC response to rRABV vaccination as anti-RABV G IgG levels were similar in APRIL-deficient and wild-type mice six months after vaccination. Mice lacking the APRIL receptor TACI demonstrated primary anti-RABV G antibody responses similar to wild-type mice following immunization with the vaccine vector indicating that this response is independent of TACI-mediated signals. Collectively, our findings demonstrate that APRIL and associated TACI signaling is dispensable for the immune response to RABV-based vaccination

Decoupled and inhomogeneous gas flows in S0 galaxies

A recent analysis of the "Einstein" sample of early-type galaxies has revealed that at any fixed optical luminosity Lb S0 galaxies have lower mean X-ray luminosity Lx per unit Lb than ellipticals. Following a previous analytical investigation of this problem (Ciotti & Pellegrini 1996), we have performed 2D numerical simulations of the gas flows inside S0 galaxies in order to ascertain the effectiveness of rotation and/or galaxy flattening in reducing the Lx/Lb ratio. The flow in models without SNIa heating is considerably ordered, and essentially all the gas lost by the stars is cooled and accumulated in the galaxy center. If rotation is present, the cold material settles in a disk on the galactic equatorial plane. Models with a time decreasing SNIa heating host gas flows that can be much more complex. After an initial wind phase, gas flows in energetically strongly bound galaxies tend to reverse to inflows. This occurs in the polar regions, while the disk is still in the outflow phase. In this phase of strong decoupling, cold filaments are created at the interface between inflowing and outflowing gas. Models with more realistic values of the dynamical quantities are preferentially found in the wind phase with respect to their spherical counterparts of equal Lb. The resulting Lx of this class of models is lower than in spherical models with the same Lb and SNIa heating. At variance with cooling flow models, rotation is shown to have only a marginal effect in this reduction, while the flattening is one of the driving parameters for such underluminosity, in accordance with the analytical investigation.Comment: 32 pages LaTex file, plus 5 .ps figures and macro aasms4.sty -- Accepted on Ap

Roche Lobe Overflow from Dwarf Stellar Systems

We use both analytical analyses and numerical simulations to examine the evolution of residual gas within tidally-limited dwarf galaxies and globular clusters. If the gas sound speed exceeds about 10% of the central velocity dispersion, as is the case for ionized gas within small stellar systems, the gas shall have significant density at the tidal radius, and the gas may be lost on timescales as short as a few times the sound crossing time of the system. In colder systems, the density at the tidal radius is much lower, greatly reducing the mass loss rate, and the system may retain its gas for a Hubble time. The tidally removed gas shall follow an orbit close to that of the original host system, forming an extended stream of ionized, gaseous debris. Tidal mass loss severely limits the ability of dwarf systems to continuously form stars. The ordinary gas content in many dwarf galaxies is fully ionized during high red-shift epochs, possibly preventing star formation in some systems, leading to the formation of starless, dark-matter concentrations. In either the field or in the center of galaxy clusters, ionized gas may be retained by dwarf galaxies, even though its sound speed may be comparable to or even exceed the velocity dispersion. These processes may help to explain some observed differences among dwarf galaxy types, as well as observations of the haloes of massive galaxies.Comment: 28 pages, LaTeX, AASTex macro

Improved photometry of SDSS crowded field images: Structure and dark matter content in the dwarf spheroidal galaxy Leo I

We explore how well crowded field point-source photometry can be accomplished with SDSS data: We present a photometric pipeline based on DoPhot, and tuned for analyzing crowded-field images from the SDSS. Using Monte Carlo simulations we show that the completeness of source extraction is above 80% to i < 21 (AB) and a stellar surface density of about 200 sq.amin. Hence, a specialized data pipeline can efficiently be used for e.g. nearby resolved galaxies in SDSS images, where the standard SDSS photometric package Photo, when applied in normal survey mode, gives poor results. We apply our pipeline to an area of about 3.55sq.deg. around the dwarf spheroidal galaxy (dSph) Leo I, and construct a high S/N star-count map of Leo I via an optimized filter in color-magnitude space (g,r,i). Although the radial surface-density profile of the dwarf deviates from the best fit empirical King model towards outer radii, we find no evidence for tidal debris out to a stellar surface-density of 4*10^(-3) of the central value. We determine the total luminosity of Leo I, and model its mass using the spherical and isotropic Jeans equation. Assuming that 'mass follows light' we constrain a lower limit of the total mass of the dSph to be (1.7+/-0.2)*10^7 Msol. Contrary, if the mass in Leo I is dominated by a constant density dark-matter (DM) halo, then the mass within the central 12' is (2+/-0.6)*10^8 Msol. This leads to a mass-to-light ratio of >>6 (Ic_sol), and possibly >75 if the DM halo dominates the mass and extends further out than 12'. In summary, our results show that Leo I is a symmetric, relaxed and bound system; this supports the idea that Leo I is a dark-matter dominated system.Comment: 13 pages, 11 figures; accepted for publication in A

Is trivial the antiferromagnetic RP(2) model in four dimensions?

We study the antiferromagnetic RP(2) model in four dimensions. We find a second order transition with two order parameters, one ferromagnetic and the other antiferromagnetic. The antiferromagnetic sector has mean-field critical exponents and a renormalized coupling which goes to zero in the continuum limit. The exponents of the ferromagnetic channel are not the mean-field ones, but the difference can be interpreted as logarithmic corrections. We perform a detailed analysis of these corrections and conclude the triviality of the continuum limit of this model.Comment: 21 pages, 5 figures, LaTeX2

Orientational Defects in Ice Ih: An Interpretation of Electrical Conductivity Measurements

We present a first-principles study of the structure and energetics of Bjerrum defects in ice Ih and compare the results to experimental electrical conductivity data. While the DFT result for the activation energy is in good agreement with experiment, we find that its two components have quite different values. Aside from providing new insight into the fundamental parameters of the microscopic electrical theory of ice, our results suggest the activity of traps in doped ice in the temperature regime typically assumed to be controlled by the free migration of L defects.Comment: 4 pages, 4 Figures, 1 Tabl

Understanding uncertainty in temperature effects on vector-borne disease: A Bayesian approach

Extrinsic environmental factors influence the distribution and population dynamics of many organisms, including insects that are of concern for human health and agriculture. This is particularly true for vector-borne infectious diseases, like malaria, which is a major source of morbidity and mortality in humans. Understanding the mechanistic links between environment and population processes for these diseases is key to predicting the consequences of climate change on transmission and for developing effective interventions. An important measure of the intensity of disease transmission is the reproductive number $R_0$. However, understanding the mechanisms linking $R_0$ and temperature, an environmental factor driving disease risk, can be challenging because the data available for parameterization are often poor. To address this we show how a Bayesian approach can help identify critical uncertainties in components of $R_0$ and how this uncertainty is propagated into the estimate of $R_0$. Most notably, we find that different parameters dominate the uncertainty at different temperature regimes: bite rate from 15-25$^\circ$ C; fecundity across all temperatures, but especially $\sim$25-32$^\circ$ C; mortality from 20-30$^\circ$ C; parasite development rate at $\sim$15-16$^\circ$C and again at $\sim$33-35$^\circ$C. Focusing empirical studies on these parameters and corresponding temperature ranges would be the most efficient way to improve estimates of $R_0$. While we focus on malaria, our methods apply to improving process-based models more generally, including epidemiological, physiological niche, and species distribution models.Comment: 27 pages, including 1 table and 3 figure

Character Strengths and Deep Connections Following Hurricanes Katrina and Rita: Spiritual and Secular Pathways to Resistance Among Volunteers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/100170/1/jssr12043.pd

The need to promote behaviour change at the cultural level: one factor explaining the limited impact of the MEMA kwa Vijana adolescent sexual health intervention in rural Tanzania. A process evaluation

Background - Few of the many behavioral sexual health interventions in Africa have been rigorously evaluated. Where biological outcomes have been measured, improvements have rarely been found. One of the most rigorous trials was of the multi-component MEMA kwa Vijana adolescent sexual health programme, which showed improvements in knowledge and reported attitudes and behaviour, but none in biological outcomes. This paper attempts to explain these outcomes by reviewing the process evaluation findings, particularly in terms of contextual factors. Methods - A large-scale, primarily qualitative process evaluation based mainly on participant observation identified the principal contextual barriers and facilitators of behavioural change. Results - The contextual barriers involved four interrelated socio-structural factors: culture (i.e. shared practices and systems of belief), economic circumstances, social status, and gender. At an individual level they appeared to operate through the constructs of the theories underlying MEMA kwa Vijana - Social Cognitive Theory and the Theory of Reasoned Action – but the intervention was unable to substantially modify these individual-level constructs, apart from knowledge. Conclusion - The process evaluation suggests that one important reason for this failure is that the intervention did not operate sufficiently at a structural level, particularly in regard to culture. Recently most structural interventions have focused on gender or/and economics. Complementing these with a cultural approach could address the belief systems that justify and perpetuate gender and economic inequalities, as well as other barriers to behaviour change